Circulating ADAMTS-12 levels in early- and late-onset severe preeclampsia

Abstract

Aim of this study is to determine whether maternal serum ADAMTS-12 levels differ among early-onset (<34 th week) severe preeclampsia (EOS-PE), late-onset (≥ 34 th week) severe preeclampsia (LOS-PE), and uncomplicated pregnancies. In this case-control study, maternal serum samples obtained from 22 pregnant patients with EOS-PE, 25 pregnant patients with LOS-PE, and 35 healthy patients with uncomplicated pregnancies (control group). The distinctly higher rate of negative perinatal outcomes in both EOS-PE and LOS-PE patients were recorded. There were no significant differences among the ADAMTS-12 levels of the groups. The main questions that need to be answered are whether the only difference between these two diseases is the time of their onset and whether the only difference between them with respect to fetal morbidity and mortality is prematurity.