Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome

Krzystek−Korpacka, Małgorzata; Patryn, Eliza; Bednarz−Misa, Iwona; Mierzchała, Magdalena; Hotowy, Katarzyna; Czapińska, Elżbieta; Kustrzeba−Wójcicka, Irena; Gamian, Andrzej; Noczyńska, Anna

doi:10.1515/jpem.2011.323

Cited by 17 publications

(18 citation statements)

References 34 publications

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“…However, recently, FABP proteins were discovered to possess extracellular functions as well, carrying lipids between tissues 35 . Additionally, studies have reported that extracellular FABP proteins were altered in metabolism-associated diseases 17, 30, 36–41 . Cardiac FABP, also known as H-FABP or FABP3, was first observed in reproductive tissues such as ovary and placenta, where it performed both intra- and extracellular functions 17, 20 .…”

Section: Discussionmentioning

confidence: 99%

Fatty Acid Binding Protein 3 And Transzonal Projections Are Involved In Lipid Accumulation During In Vitro Maturation Of Bovine Oocytes

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Silveira

Sangalli

et al. 2017

Sci Rep

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Oocytes that undergo in vitro maturation (IVM) are metabolically abnormal and accumulate excess lipid content. However, the mechanism of lipid accumulation and the role of cumulus cells in this process are unclear. Recently, it was shown that fatty acid binding proteins (FABPs) performed intra- and extracellular fatty acid transport. We postulated that FABP3 might be responsible for fatty acid transport from cumulus cells to the oocytes via transzonal projections (TZPs) during IVM. Transcript and protein levels of FABP3 were analyzed in both in vivo- and in vitro-matured cumulus-oocyte-complexes and were increased in IVM samples. Further analysis showed increased lipid content in oocytes and cumulus cells in IVM samples compared to in vivo-derived. We therefore speculated that altered traffic of fatty acids via FABP3 during IVM was the mechanism leading to the excess of lipids accumulated within IVM oocytes. Furthermore, we demonstrated an increase in FABP3 levels and lipid content during the first 9 h of IVM, further strengthening the possibility of fatty acid transport via FABP3 and TZPs. Additionally, disruptions of TZPs during IVM decreased lipid accumulation in oocytes. Our results shed light on a possible mechanism involving FABP3 and TZPs that causes excess lipid accumulation in oocytes during IVM.

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Section: Discussionmentioning

confidence: 99%

Fatty Acid Binding Protein 3 And Transzonal Projections Are Involved In Lipid Accumulation During In Vitro Maturation Of Bovine Oocytes

Collado

Silveira

Sangalli

et al. 2017

Sci Rep

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“…Yet, this protein also exerts anti‐inflammatory functions, such as directly suppressing macrophage pro‐inflammatory responses . Down regulation of PON1 level is associated with exacerbation of obesity‐related inflammation and oxidative stress . We determined the enzymatic activity of PON1 in serum, and the total antioxidant activity, and both were numerically lower in control animals.…”

Section: Discussionmentioning

confidence: 99%

Growth promotion in pigs by oxytetracycline coincides with down regulation of serum inflammatory parameters and of hibernation‐associated protein HP‐27

et al. 2016

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The growth promoting effect of supplementing animal feed with antibiotics like tetracycline has traditionally been attributed to their antibiotic character. However, more evidence has been accumulated on their direct anti-inflammatory effect during the last two decades. Here we used a pig model to explore the systemic molecular effect of feed supplementation with sub therapeutic levels of oxytetracycline (OTC) by analysis of serum proteome changes. Results showed that OTC promoted growth, coinciding with a significant down regulation of different serum proteins related to inflammation, oxidation and lipid metabolism, confirming the anti-inflammatory mechanism of OTC. Interestingly, apart from the classic acute phase reactants also down regulation was seen of a hibernation associated plasma protein (HP-27), which is to our knowledge the first description in pigs. Although the exact function in non-hibernators is unclear, down regulation of HP-27 could be consistent with increased appetite, which is possibly linked to the anti-inflammatory action of OTC. Given that pigs are good models for human medicine due to their genetic and physiologic resemblance, the present results might also be used for rational intervention in human diseases in which inflammation plays an important role such as obesity, type 2 diabetes and cardiovascular diseases.

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“…However, our findings about the correlation between GPX activity in erythrocytes and the studied phenotypes and biomarkers reveal a potential early connection between these phenomena. We found GPX activity to be positively correlated with A-FABP, a biomarker closely associated with obesity and metabolic syndrome in children and adults [37,38]. A-FABP participates in the regulation of metabolism and adipocyte differentiation by its binding and transport of lipids.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Polymorphisms for Glutathione Peroxidase Genes with Obesity in Spanish Children

et al. 2014

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Background/Aims: Altered expression and activity of the antioxidant enzymes glutathione peroxidases (GPXs) have been observed in obesity in human and animal studies. We aimed to study 59 single nucleotide polymorphisms (SNPs) for GPX1-7 genes and to characterize their association with prepubertal childhood obesity and its associated biomarkers. Methods: This case-control study included 193 obese and 191 normal-weight prepubertal Spanish children, in whom anthropometry, biochemical parameters, adipokines, antioxidant enzyme erythrocyte activities and biomarkers of oxidative stress, inflammation and cardiovascular risk were measured. The genotype analysis was performed in the Illumina platform. PLINK and SPSS were used for statistical analyses. Results: We found SNPs rs757228 and rs8103188 (GPX4) to be negatively associated and rs445870 (GPX5) and rs406113 (GPX6) to be positively associated with obesity in children. The variant rs2074451 (GPX4) increased GPX activity in erythrocytes. Although we did not find significant differences in erythrocyte GPX activity between obese and normal-weight children, GPX activity was found to be positively and significantly correlated with blood pressure, adipocyte fatty acid-binding protein and high-sensitivity C-reactive protein. Conclusions: The GPX variants rs757228, rs8103188, rs445870 and rs406113 were associated with prepubertal childhood obesity. However, erythrocyte GPX activity was not altered in obese prepubertal Spanish children.

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Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome

Cited by 17 publications

References 34 publications

Fatty Acid Binding Protein 3 And Transzonal Projections Are Involved In Lipid Accumulation During In Vitro Maturation Of Bovine Oocytes

Fatty Acid Binding Protein 3 And Transzonal Projections Are Involved In Lipid Accumulation During In Vitro Maturation Of Bovine Oocytes

Growth promotion in pigs by oxytetracycline coincides with down regulation of serum inflammatory parameters and of hibernation‐associated protein HP‐27

Association of Genetic Polymorphisms for Glutathione Peroxidase Genes with Obesity in Spanish Children

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