Circulating adrenaline released by sympathoadrenal activation elicits acute vasodilatation in the rat masseter muscle

Ishii, Hisayoshi; Niioka, Takeharu; Izumi, Hiroshi

doi:10.1016/j.archoralbio.2009.01.012

Cited by 19 publications

(19 citation statements)

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“…Capsaicin is also known to enhance adrenal medullary catecholamine secretion, especially adrenaline (44,45), which is suggested to be important in the modulation of vasomotor responses mediated by ␣-and ␤-adrenergic receptors in the masseter muscle, as reported by us previously (10). However, circulating adrenaline appeared not to be involved in the inhibitory effects of capsaicin injection on MBF increases evoked by cVN stimulation, because intravenous administration of either phentolamine or propranolol had no effect on this inhibitory effect (Fig.…”

Section: Discussionmentioning

confidence: 53%

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

Ishii

Izumi

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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Ishii H, Izumi H. GABAB receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle. Am J Physiol Regul Integr Comp Physiol 302: R776 -R784, 2012. First published January 4, 2012; doi:10.1152/ajpregu.00569.2011.-The present study was designed to examine whether trigeminal nociceptive inputs are involved in the modulation of parasympathetic reflex vasodilation in the jaw muscles. This was accomplished by investigating the effects of noxious stimulation to the orofacial area with capsaicin, and by microinjecting GABA A and GABAB receptor agonists or antagonists into the nucleus of the solitary tract (NTS), on masseter hemodynamics in urethane-anesthetized rats. Electrical stimulation of the central cut end of the cervical vagus nerve (cVN) in sympathectomized animals bilaterally increased blood flow in the masseter muscle (MBF). Increases in MBF evoked by cVN stimulation were markedly reduced following injection of capsaicin into the anterior tongue in the distribution of the lingual nerve or lower lip, but not when injected into the skin of the dorsum of the foot. Intravenous administration of either phentolamine or propranolol had no effect on the inhibitory effects of capsaicin injection on the increases of MBF evoked by cVN stimulation, which were largely abolished by microinjecting the GABA B receptor agonist baclofen into the NTS. Microinjection of the GABAB receptor antagonist CGP-35348 into the NTS markedly attenuated the capsaicin-induced inhibition of MBF increase evoked by cVN stimulation, while microinjection of the GABA A receptor antagonist bicuculline did not. Our results indicate that trigeminal nociceptive inputs inhibit vagal-parasympathetic reflex vasodilation in the masseter muscle and suggest that the activation of GABA B rather than GABA A receptors underlies the observed inhibition in the NTS.capsaicin; cervical vagus nerve; baclofen; bicuculline; CGP-35348

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Section: Discussionmentioning

confidence: 53%

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

Ishii

Izumi

2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…These cardiovascular responses could be mediated through normalisation of sympathovagal balance. Dysregulation of sympathetic nervous system signalling is associated with diabetes mellitus, obesity and cardiovascular disease [36,37] possibly by the increased activation of the sympathetic nervous system by angiotensin II [38,39]. Further, glucose, insulin and NEFA potently stimulate sympathetic activity and noradrenaline release [40].…”

Section: Plasma and Tissue Concentrations Of α-Tocopherol α- γ-And mentioning

confidence: 99%

Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats

Wong

Ward

Fong³

et al. 2015

Eur J Nutr

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“…However, sympathetic vasoconstriction is under tonic control from the superior cervical sympathetic trunk (CST) [ 6 ]. It has also been reported that the release of circulating adrenaline through activation of the sympathoadrenal system is involved in vasodilation in the masseter muscle through a β-adrenergic mechanism [ 7 ]. These observations suggest that neural and humoral autonomic mechanisms and their interactions may be important for the maintenance of blood flow in the masseter muscle (MBF) and the activity of the masseter muscle.…”

Section: Introductionmentioning

confidence: 99%

Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α2-adrenoceptors in the rat masseter muscle

Ishii

Sato

2016

J Physiol Sci

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Neural and humoral autonomic mechanisms may be important in the maintenance of blood flow in the masseter muscle (MBF). However, their interactions remain unclear. In this study, we examined interactions between neural and humoral regulation of MBF and investigated the mechanisms mediating these interactions in urethane-anesthetized rats. Stimulation of the adrenal nerve (AN) projecting to the adrenal medulla increased MBF, and this increase was mediated by β-adrenoceptors. Sectioning of the superior cervical sympathetic trunk (CST) significantly inhibited increases in MBF induced by AN stimulation during high activity in the CST, but not during low activity. AN stimulation with clonidine after CST sectioning induced a significant increased in MBF, however phenylephrine had no observable effect. Pretreatment with yohimbine or propranolol significantly inhibited the increase in the MBF. Our results suggest an interaction between β-adrenergic vasodilation evoked by circulating adrenaline and the cervical sympathetic nerves that is mediated by α2-adrenoceptors in the masseter muscle.

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Circulating adrenaline released by sympathoadrenal activation elicits acute vasodilatation in the rat masseter muscle

Cited by 19 publications

References 24 publications

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

GABA_B receptors in the NTS mediate the inhibitory effect of trigeminal nociceptive inputs on parasympathetic reflex vasodilation in the rat masseter muscle

Anti-inflammatory γ- and δ-tocotrienols improve cardiovascular, liver and metabolic function in diet-induced obese rats

Interactions between β-adrenergic vasodilation and cervical sympathetic nerves are mediated by α2-adrenoceptors in the rat masseter muscle

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