Circulating chemerin level is associated with metabolic, biochemical and haematological parameters—A population‐based study

Abstract

Objective: This study aims to analyse the association of chemerin levels with several metabolic, biochemical and haematological parameters in a large Taiwanese population with relative healthy status.Design: Cross-sectional study.Methods: Data of 4101 healthy participants without history of hypertension, diabetes, dyslipidaemia and renal insufficiency from Taiwan Biobank were analysed. The demographic, biochemical and haematologic parameters were retrieved from the database. Chemerin levels were measured using commercially available enzyme-linked immunosorbent assay. Univariate and multivariate analysis was performed to test the independent correlates of chemerin. Results:In the univariate analysis, circulating chemerin levels were positively associated with body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), systolic (SBP) and diastolic blood pressure (DBP), haemoglobin A1C (HbA1C), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), creatinine, uric acid, alanine aminotransferase (ALT), gamma-glutamyl transferase (γ-GT), leucocyte and platelet counts both in men and women and negatively associated with highdensity lipoprotein cholesterol (HDL-C), estimated glomerular filtration rate (eGFR) and total bilirubin. In the multivariate analysis, BMI, HbA1C, triglyceride, uric acid, γ-GT and platelet counts predicted chemerin levels independently both in men and in women with positive correlation, while eGFR, total bilirubin and HDL-C predicted circulating chemerin levels independently with negative correlation.Conclusions: Chemerin level is independently associated with multiple metabolic, biochemical and haematological parameters. This study provides further evidence on the molecular basis linking obesity with several human diseases.

Determinants of elevated chemerin as a novel biomarker of immunometabolism: data from a large population-based cohort

“…Also systolic and diastolic blood pressure were selected to contribute to the variation of chemerin. Similar results were previously reported for an association between chemerin and impaired renal function 39,40 and other metabolic phenotypes that may lead to liver and kidney damage 4,41,42 . Our findings for blood pressure are supported by mechanistic research on chemerin that has been focused on the vascular system and hypertension 43 .…”

Chemokine-like Receptor 1 in Brain of Spontaneously Hypertensive Rats Mediates Systemic Hypertension

“…While concentration of chemerin in plasma of the healthy human subject was approximately 50 ng/mL, that in the obese subjects that were related to hypertension through the augmentation of SNA was increased to 350 ng/mL [26,27]. Furthermore, it was reported that concentration of chemerin in plasma correlated positively with increased systemic blood pressure [28]. Thus, it was expected that chemerin, which was increased in peripheral tissue with hypertension, acted on central nervous system in SHR, and mediated pressor response through the augmentation of SNA.…”

Chemerin Forms: Their Generation and Activity

“…There are limited comparative data on any potential differences in circulating chemerin levels in men and women; some studies have shown that women have higher chemerin levels than men [ 91 , 92 ], but other studies have reached the opposite conclusion [ 93 ]. Although reports are available on chemerin levels in different racial or ethnic groups, the influence of this factor on circulating chemerin has not been formally compared within a single study to our knowledge.…”

“…The role of chemerin in pediatric and gestational diabetes will not be discussed here, although there is good evidence of its involvement [ 100 , 101 ]. There are many reports describing chemerin levels along with other adipokines in various cohorts showing that chemerin levels are associated with disorders involved with energy balance [ 81 , 82 , 92 , 102 ]. Those reports are in agreement that levels of circulating chemerin are higher in people with obesity.…”