Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia

Krauss, Thomas F.; Kuhn, Walther; Lakoma, Cathleen; Augustin, Hellmut G.

doi:10.1016/s0002-9378(97)70213-8

Cited by 152 publications

(92 citation statements)

References 27 publications

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“…Within control group it demonstrated significant correlation with hsCRP. Elevated sPECAM-1 has been reported in pregnancy induced hypertension by Zeister et al (36) and in women with preclampsia by Krauss et al (37,38).…”

Section: Cell Adhesion Molecules In Hypertensionmentioning

confidence: 89%

Circulating levels of cell adhesion molecules in hypertension

Shalia

Mashru

Vasvani

et al. 2009

Indian J Clin Biochem

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Section: Cell Adhesion Molecules In Hypertensionmentioning

confidence: 89%

Circulating levels of cell adhesion molecules in hypertension

Shalia

Mashru

Vasvani

et al. 2009

Indian J Clin Biochem

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“…[22][23][24] Even significantly lower sICAM-1 values in preeclampsia have been reported. 25 These conflicting results might derive from the small number of patients studied or from the observed large variations of sICAM-1 concentrations, as in our study.…”

Section: Discussionmentioning

confidence: 98%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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OBJECTIVES:Maternal serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in preeclampsia to investigate whether these molecules could be helpful with regard to this pregnancy complication. STUDY DESIGN:The study population was composed of 30 preeclamptic patients with a mean gestational age of 35.5 Ϯ 4.6 weeks and 20 age-matched and gestational age-matched normotensive uncomplicated pregnancies (controls). Blood samples from 7 of the 30 preeclamptic patients and 15 of the 20 controls in the second trimester were also analyzed. Data were analyzed by parametric methods. RESULTS:Significantly higher maternal serum sVCAM-1 levels were found in both groups of preeclamptic patients with and without fetal growth restriction (981 Ϯ 145 ng/ml; n ϭ 13; p Ͻ 0.0005 and 846 Ϯ 84 ng/ml; p Ͻ 0.02, respectively) compared with controls (668 Ϯ 186 ng/ml). In contrast, no significant difference was found in maternal serum sICAM-1 levels between preeclamptic and normotensive pregnancies, or in both adhesion molecules (1) in the controls between second and third trimester samples and (2) in the second trimester between pregnant women who developed preeclampsia later and gestational age-matched controls. CONCLUSION:These findings show a selective significant elevation of maternal serum sVCAM-1 in preeclampsia, with the highest values in cases complicated with fetal growth restriction, perhaps reflecting its angiogenic function. Hence, sVCAM-1 could be helpful in the diagnosis of this fetal complication in preeclampsia.

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“…Exaggerated inflammatory responses were believed to be a significant pathophysiological event during preeclampsia (25). Several biochemical parameters indicate that endothelial dysfunction is related to the inflammatory response in preeclampsia, such as elevated serum cellular fibronectin, endothelial adhesion molecules P-selectin, the intercellular adhesion molecule, the vascular cell adhesion molecule, and the platelet endothelial cell adhesion molecule levels (2,19,21,31,33). A previous study reported that the pro-inflammatory cytokines increased significantly in preeclamptic women compared to women with normal pregnancies at sea level (28).…”

Section: Discussionmentioning

confidence: 99%

The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients

So¹,

Suekit²,

Ao³

et al. 2015

Acta Physiologica Hungarica

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Placental hypoxia, a major component of the pathophysiology of preeclampsia, is associated with various maternal vascular and endothelial dysfunctions. The higher incidence of preeclampsia at high altitude remains incompletely explained. The aim of the present study was to investigate the effect of high altitude on some endothelial and vascular dysfunction markers in normal and preeclamptic pregnancies. Eighty pregnant women (Paras 2-4) were enrolled in this study, which included four groups (each n = 20): normal pregnancies at low altitude (NL), normal pregnancies at high altitude (NH), preeclamptic pregnancies at low altitude (PL), and preeclamptic pregnancies at high altitude (PH). In normal pregnancies at high altitude serum ET-1, plasma TXA 2 , and serum TNF-α levels increased significantly with a significant reduction in plasma PGI 2 (66.81 ± 7.36, 122.86 ± 13.37, 102.23 ± 13.31, 191.57 ± 19.68, respectively) compared with the NL group (48.92 ± 4.58, 89.03 ± 10.67, 69.86 ± 7.97, 238.01 ± 24.55, respectively). In preeclampsia at low altitude serum ET-1, plasma TXA 2 , and serum TNF-α levels increased significantly with a significant reduction in plasma PGI 2 (88.39 ± 9.54, 162.73 ± 15.92, 142.39 ± 15.37, 149.155 ± 15.66, respectively) compared with both NL and NH groups. High altitude significantly augmented these changes in preeclamptic patients (117.75 ± 12.96, 211.01 ± 22.69, 196.86 ± 17.64, 111.92 ± 10.74) compared with PL, NH and NL groups. In conclusion hypoxia at high altitude aggravated the disturbances in the levels of ET-1, TXA 2 , PGI 2 and TNF-α associated with preeclampsia. This may contribute to the higher risk of preeclampsia at high altitude.

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Circulating endothelial cell adhesion molecules as diagnostic markers for the early identification of pregnant women at risk for development of preeclampsia

Cited by 152 publications

References 27 publications

Circulating levels of cell adhesion molecules in hypertension

Circulating levels of cell adhesion molecules in hypertension

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients

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