Circulating ERBB3 levels are inversely associated with the risk of overweight-related hypertension: a cross-sectional study

Abstract

Background Hypertension and overweight are independent risk factors for cardiovascular disease, and overweight increase the risk of developing high blood pressure. ERBB3( also known as HER3) plays a considerable role in the development of cardiovascular diseases. However, the effect of ERBB3 levels in hypertensive overweight patients is unknown. The aim of this study was to assess the association between ERBB3 levels and hypertension in overweight Chinese patients. Methods We evaluated the height,weight, blood pressure, biochemical indicators, and ERBB3 levels in 128 Chinese adults aged 33–79 years. Plasma ERBB3 levels were assessed by the enzyme-linked immunosorbent assay, and body mass index(BMI) was calculated as body weight divided by height squared. Participants were allocated into three groups according to blood pressure and BMI: healthy control (CNT, n = 31; normotensive and non-overweight), hypertension (HT, n = 33; hypertension and non-overweight), and hypertension with overweight (HTO, n = 64; hypertension and overweight). Statistical significance was defined as a two-tailed P < 0.05. Results There was no significant difference in mean ERBB3 levels among the three groups, although a linear decrease from CNT (1.13 ± 0.36), HT (1.03 ± 0.36), to HTO (0.84 ± 0.26 ng/mL) was observed in men (P = 0.007). Among the drinking population, the ERBB3 level was significantly reduced in the HTO group as compared with those of the CNT and HT groups (0.76 ± 0.23 versus 1.18 ± 0.37 and 1.20 ± 0.30, respectively). ERBB3 levels were negatively correlated with diastolic blood pressure in men (r= − 0.293, P = 0.012), smoking (r= − 0.47, P = 0.004), and drinking (r = − 0.387, P = 0.008). BMI in men and among drinkers, and uric acid among drinkers were negatively correlated with ERBB3 levels. Multivariate conditional logistic regression showed that plasma ERBB3 levels were associated with a reduced risk of HTO in men [odds ratio (OR) 0.054; 95 % confidence interval (CI): 0.007–0.412) and drinkers (OR 0.002; 95 % CI: 0.000–0.101). Conclusions ERBB3 may contribute to the pathogenesis of hypertension in overweight patients, with BMI, gender, and drinking all potentially modulating the process.

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseases

“…38 GeneNc polymorphisms of ERBB3 were reported to be associated with coronary artery disease in Han and Uygur ancestries of China, 39 and circulaNng protein levels with overweight-related hypertension in the same populaNon. 40 Only 2 biomarkers (LGALS4, MMP12) were overlapped with the targets derived from the forward-MR analyses (Table S5), suggesNng disNnct roles of proteins on CVD pathogenesis. We also found NPPB, the gene encoding preprohormone (propro-B-type natriureNc pepNde, preproBNP) in cardiomyocytes, as a biomarker specifically to dilated cardiomyopathy.…”

Interplay of Serum Leptin, Tumor Necrosis Factor Alpha, and Testosterone in Overweight-Related Hypertensive Men

“…The OW status increases the risk of the development of high BP. It is well studied in the Framingham Study that high BP or HT [10] and OW [11] (are independent risk factors for CVD [12,13]. It is documented that the occurrence of HT could increase the BMI [14].…”