Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity

Kobayashi, Yoshinao; Eguchi, Akiko; Imami, Koshi; Tempaku, Mina; Izuoka, Kiyora; Takase, Takafumi; Kainuma, Keigo; Nagao, Mizuho; Furuta, Noriko; Iwasa, Motoh; Nakagawa, Hayato; Fujisawa, Takao; Togashi, Kenji

doi:10.1007/s00109-023-02386-5

J Mol Med

2023

DOI: 10.1007/s00109-023-02386-5

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Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity

Yoshinao Kobayashi,

Akiko Eguchi,

Koshi Imami

et al.

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2024

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Cited by 2 publications

References 68 publications

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Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis

DiStefano,

Piras,

et al. 2024

Clinical Nutrition ESPEN

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Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis

DiStefano,

Piras,

et al. 2024

Clinical Nutrition ESPEN

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How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet’s Activatory and Negative Signaling

Montecino-Garrido,

Trostchansky,

Espinosa-Parrilla

et al. 2024

IJMS

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Platelets are small cell fragments that play a crucial role in hemostasis, requiring fast response times and fine signaling pathway regulation. For this regulation, platelets require a balance between two pathway types: the activatory and negative signaling pathways. Activatory signaling mediators are positive responses that enhance stimuli initiated by a receptor in the platelet membrane. Negative signaling regulates and controls the responses downstream of the same receptors to roll back or even avoid spontaneous thrombotic events. Several blood-related pathologies can be observed when these processes are unregulated, such as massive bleeding in activatory signaling inhibition or thrombotic events for negative signaling inhibition. The study of each protein and metabolite in isolation does not help to understand the role of the protein or how it can be contrasted; however, understanding the balance between active and negative signaling could help develop effective therapies to prevent thrombotic events and bleeding disorders.

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Circulating extracellular vesicles are associated with pathophysiological condition including metabolic syndrome-related dysmetabolism in children and adolescents with obesity

Cited by 2 publications

References 68 publications

Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis

Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis

How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet’s Activatory and Negative Signaling

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