Circulating Heat Shock Proteins and Inflammatory Markers in Patients With Idiopathic Left Ventricular Dysfunction: Their Relationships With Myocardial and Microvascular Impairment

Giannessi, Daniela; Colotti, Chiara; Maltinti, Maristella; Ry, Silvia Del; Prontera, Concetta; Turchi, S.; LʼAbbate, Antonio; Neglia, Danilo

doi:10.1379/csc-272

Cited by 12 publications

(17 citation statements)

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“…In our study group, Hsp70 levels significantly correlated to left ventricular ejection fraction and NT-proBNP, indicating a direct relationship between worsening heart function and increased serum stress protein levels. The same associations were found by Giannessi et al (2007). The increasing serum concentration of Hsp70 with the severity of the disease seemed to be independent of the condition of the kidneys and the liver, the anaemia and the inflammation, proven by a logistic regression model.…”

Section: Discussionsupporting

confidence: 75%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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Background Circulating heat shock protein 70 (Hsp70) is present in the circulation of healthy individuals and in patients with various disorders, including chronic heart failure (CHF). However, the source and routes of release of Hsp70 is only partially characterised in clinical samples. Aims The purpose of this study was to study the clinical and biological correlates of Hsp70 in a CHF population and, for the first time, to investigate the association of HspA1B (also known as Hsp70-2) +1267 alleles with serum Hsp70 levels. Methods A total of 167 patients (123 men, 44 women) with <45% left ventricular ejection fraction (LVEF) were enrolled; serum Hsp70 level was determined by enzymelinked immunosorbent assay and HspA1B +1267 polymorphism by polymerase chain reaction-restriction fragment length polymorphism.

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Section: Discussionsupporting

confidence: 75%

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Gombos

Förhécz

Pozsonyi

et al. 2008

Cell Stress and Chaperones

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“…Subsequent work with a rat model showed that treatment with trandolapril reversed the HSP60 increases [41]. Elevated levels of circulating HSP60 have also been described in human subjects with HF due to non-atherosclerotic cardiac disease [42]. Patients with more se-vere disease showed higher levels of HSP60 and anti-HSP60 autoantibodies in the blood as compared with less severe cases, and HSP60 levels correlated also with the extent of cardiac and microvascular dysfunction [42].…”

Section: Hsp60 and The Pathogenesis Of Heart Failure (Hf) And Hypertementioning

confidence: 98%

“…Elevated levels of circulating HSP60 have also been described in human subjects with HF due to non-atherosclerotic cardiac disease [42]. Patients with more se-vere disease showed higher levels of HSP60 and anti-HSP60 autoantibodies in the blood as compared with less severe cases, and HSP60 levels correlated also with the extent of cardiac and microvascular dysfunction [42]. However, it was not clear whether the anti-HSP60 auto-antibodies were due to a previous bacterial infection.…”

Section: Hsp60 and The Pathogenesis Of Heart Failure (Hf) And Hypertementioning

confidence: 99%

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Rizzo¹,

Macario²,

Macario³

et al. 2011

CPD

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.

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“…Indicating a complex stress response, HSP70 levels were associated with left ventricular ejection fraction and NT-proBNP (Gombos et al 2008). Circulating HSP70 levels were elevated in patients with idiopathic left ventricular dysfunction (Giannessi et al 2007). Serum HSP70 was also significantly higher in heart failure patients with different types of cardiomyopathy (Wei et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure

Jenei

Gombos

Förhécz

et al. 2013

Cell Stress and Chaperones

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Predicting the survival of a patient with heart failure (HF) is a complex problem in clinical practice. Our previous study reported that extracellular HSP70 (HSPA1A) correlates with markers of heart function and disease severity in HF, but the predictive value of HSP70 is unclear. The goal of this study was to analyze extracellular HSP70 as predictive marker of mortality in HF. One hundred ninetyfive patients with systolic heart failure were enrolled and followed up for 60 months. By the end of follow-up, 85 patients were alive (survivors) and 110 died (nonsurvivors). HSP70 (measured by ELISA in the serum) was elevated in nonsurvivors, compared with survivors (0.39 [0.27-0.59] vs. 0.30 [0.24-0.43] ng/ml, respectively, p = 0.0101). In Kaplan-Meier survival analysis higher HSP70 levels above median were associated with a significantly increased mortality. In multivariable survival models, we show that HSP70 level above the median is an age-, sex-, body mass index-, creatinine-, and NT-proBNP-independent predictor of 5-year mortality in HF. Extracellular HSP70 could prove useful for estimating survival in patients with HF.

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Circulating Heat Shock Proteins and Inflammatory Markers in Patients With Idiopathic Left Ventricular Dysfunction: Their Relationships With Myocardial and Microvascular Impairment

Cited by 12 publications

References 0 publications

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure

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