Circulating immune complexes in diabetes

Mario, U. Di; Iavicoli, M; Andreani, D

doi:10.1007/bf00421850

Cited by 43 publications

(17 citation statements)

References 30 publications

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“…It is also known that number and function of T-lymphocytes are reduced at onset of IDDM [8] and this could determine an abnormal control of B-lymphocyte functions. An increased utilization of immunoglobulin in circulating immune-complexes has been also reported in the early stage of IDDM [7]. The transient alterations in IgG and IgG subclass levels observed in our patients may reflect either a suppression of immunoglobulin production or an increased utilization.…”

Section: Discussionmentioning

confidence: 50%

“…IgG subclass deficiency has been also noted in connection with auto-immune diseases such as systemic lupus erythematous, and auto-immune cytopenias [4, 191 . Much evidence suggests that insulin-dependent diabetes mellitus (IDDM) is an auto-immune disease [2,7,8,10]. Conflicting abnormalities in immunoglobulin levels have been described in IDDM [9,11,12].…”

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

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Transient IgG subclass deficiencies in newly diagnosed diabetic children

Cortona

Avanzini

Martinetti³

et al. 1992

Eur J Pediatr

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In 27 children (15 males and 12 females) with insulin-dependent diabetes mellitus (IDDM), aged 1.2-13.5 years (mean 9.9 +/- 3.6 years) we investigated immunoglobulins (IgG, IgA, IgM), IgG subclass levels and islet-cell antibodies (ICA) at diagnosis and at 6 and 12 months after disease onset. At diagnosis, IgG levels were lower than -2SD in 7 patients (26%), IgA in 1 (3.7%), IgM in 1 (3.7%). IgG subclass levels were below the 3rd percentile in 13 patients (48.1%); in particular IgG1 in 7 (26%), IgG2 in 3 (11.1%), IgG3 in 2 and IgG4 undetectable in 1 case. In 3 out of the 13 patients combined IgG1-IgG3, IgG1-IgG2 and IgG1-IgG4-IgA deficiencies were observed. ICA were greater than 20 Juvenile Diabetes Foundation units in 17/27 patients. The HLA-DR2 frequency was higher in patients with IgG subclass deficiency than in patients with normal IgG subclass levels. During follow up, IgG levels normalized in 6 patients while IgA and IgM did not change. IgG1 normalized in 5 out of the 7 patients, IgG2 in all patients while IgG3 and IgG4 did not change. One year later ICA were still present in 8/27 patients. The hypogammaglobulinaemia and IgG subclass deficiencies observed in our patients could have either a genetic or an acquired basis.

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Section: Discussionmentioning

confidence: 50%

Section: Offprint Requests To: L Cortonamentioning

confidence: 99%

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Cortona

Avanzini

Martinetti³

et al. 1992

Eur J Pediatr

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“…La positivité du test d'inhibition de mi gration des leucocytes circulants chez 60% des diabétiques insulino-dépendants en pré sence d'extraits de pancréas humains ou ani maux, mais non d'insuline [6], et la mise en évidence de complexes immuns circulants chez 60% par fixation du Clq marqué [7] apportent d'autres arguments en faveur de l'existence d'anomalies immunitaires au cours de certains diabètes.…”

Section: Marqueurs Immunologiques Du Diabète Insulino-dépendantunclassified

Bases cellulaires et génétiques des maladies endocriniennes d’origine auto-immune

Bach¹,

Charreire²

1982

Horm Res

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“…The C3 complement component, the "main element" of the complementary system, is involved in many immune mechanisms, especially the transport and the elimination of circulating immune complexes (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Application of the Time-Resolved Immunofluorometric Assay to the Study of C3 Complement Component Glycation in vitro and in vivo

Gaillard

Meillet²,

Bordas-Fonfrède³

et al. 1993

Clinical Chemistry and Laboratory Medicine

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A time-resolved immunofluorometric assay (TR-IFMA) was used for the measurement of glycated C3. The very high sensitivity of this technique allowed the direct measurement of glycated and non-glycated proteins (especially C3) in chromatography eluates. C3 glycation in vitro after incubation with 20 mmol/1 glucose was always less than 3.5% by day 5. As determined with the TR-IFMA, the means + standard deviations of glycated C3 were 0.20% + 0.04 for non-diabetic subjects and 0.88% ± 0.06 for insulindependent diabetic patients. The low percentages of glycated C3 in both our in vitro and in vivo studies show that this protein is subject to only moderate rates of glycation.

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Circulating immune complexes in diabetes

Cited by 43 publications

References 30 publications

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Bases cellulaires et génétiques des maladies endocriniennes d’origine auto-immune

Application of the Time-Resolved Immunofluorometric Assay to the Study of C3 Complement Component Glycation in vitro and in vivo

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Circulating immune complexes in diabetes

Cited by 43 publications

References 30 publications

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Transient IgG subclass deficiencies in newly diagnosed diabetic children

Bases cellulaires et g&eacute;n&eacute;tiques des maladies endocriniennes d&rsquo;origine auto-immune

Application of the Time-Resolved Immunofluorometric Assay to the Study of C3 Complement Component Glycation in vitro and in vivo

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Bases cellulaires et génétiques des maladies endocriniennes d’origine auto-immune