Circulating irisin is linked to bone mineral density in geriatric Chinese men

Zhang, Jianmei; Huang, Xiaocheng; Yu, Rongbo; Wang, Yan; Gao, Congcong

doi:10.1515/med-2020-0215

Cited by 14 publications

(15 citation statements)

References 16 publications

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“…In a case-control study by Zhang et al, geriatric Chinese men with osteoporosis or osteopenia had reduced serum irisin levels compared to age-matched controls without osteoporosis or osteopenia [93]. In addition, multiple linear regression analysis showed that serum irisin levels are an independent factor for bone marrow density (Table 6) [93].…”

Section: Role Of Irisin On Bone Homeostasis: Clinical Evidencementioning

confidence: 99%

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Kornel

Hartogh

Klentrou

et al. 2021

IJMS

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Bone is a highly dynamic tissue that is constantly adapting to micro-changes to facilitate movement. When the balance between bone building and resorption shifts more towards bone resorption, the result is reduced bone density and mineralization, as seen in osteoporosis or osteopenia. Current treatment strategies aimed to improve bone homeostasis and turnover are lacking in efficacy, resulting in the search for new preventative and nutraceutical treatment options. The myokine irisin, since its discovery in 2012, has been shown to play an important role in many tissues including muscle, adipose, and bone. Evidence indicate that irisin is associated with increased bone formation and decreased bone resorption, leading to reduced risk of osteoporosis in post-menopausal women. In addition, low serum irisin levels have been found in individuals with osteoporosis and osteopenia. Irisin targets key signaling proteins, promoting osteoblastogenesis and reducing osteoclastogenesis. The present review summarizes the existing evidence regarding the effects of irisin on bone homeostasis.

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Section: Role Of Irisin On Bone Homeostasis: Clinical Evidencementioning

confidence: 99%

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Kornel

Hartogh

Klentrou

et al. 2021

IJMS

View full text Add to dashboard Cite

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“…FNDC5 and its cleaved circulating form irisin are positively correlated with an active lifestyle ( Tenorio et al, 2017 ). Vigorous-intensity physical activity had a high serum level of irisin ( Morelli et al, 2020 ), which positively related to bone mechanical properties ( Zhang et al, 2020 ). Furthermore, treatment with irisin is found to improve BMD and biomechanical properties in murine models ( Colaianni et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Irisin in Exercise-Mediated Bone Health

Liu

Guo

Chen

et al. 2021

Front. Cell Dev. Biol.

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Exercise training promotes physical and bone health, and is the first choice of non-drug strategies that help to improve the prognosis and complications of many chronic diseases. Irisin is a newly discovered peptide hormone that modulates energy metabolism and skeletal muscle mass. Here, we discuss the role of irisin in bone metabolism via exercise-induced mechanical forces regulation. In addition, the role of irisin in pathological bone loss and other chronic diseases is also reviewed. Notably, irisin appears to be a key determinant of bone mineral status and thus may serve as a novel biomarker for bone metabolism. Interestingly, the secretion of irisin appears to be mediated by different forms of exercise and pathological conditions such as diabetes, obesity, and inflammation. Understanding the mechanism by which irisin is regulated and how it regulates skeletal metabolism via osteoclast and osteoblast activities will be an important step toward applying new knowledge of irisin to the treatment and prevention of bone diseases such as osteolysis and other chronic disorders.

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“…The results showed that irisin was linearly correlated with BMD at different bone sites and that there was a systematic association between circulating irisin and bone mass (Colaianni et al, 2017a). Zhang et al (2020) also demonstrated a positive correlation between irisin levels and BMD in older Chinese men in 2020, and these results supported the idea that irisin exerts a protective effect on bone tissue. In 2022, Wang et al investigated the relationship between serum levels of irisin and BMD in patients with newonset type 2 diabetes and observed that decreased serum levels of irisin were negatively associated with BMD.…”

Section: The E Ects Of Irisin On Osteoarthritis Irisin and Bone Miner...mentioning

confidence: 54%

Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review

Ning

Wang

Zhang

2022

Front. Aging Neurosci.

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Osteoarthritis is a chronic degenerative musculoskeletal disease characterized by pathological changes in joint structures along with the incidence of which increases with age. Exercise is recommended for all clinical treatment guidelines of osteoarthritis, but the exact molecular mechanisms are still unknown. Irisin is a newly discovered myokine released mainly by skeletal muscle in recent years—a biologically active protein capable of being released into the bloodstream as an endocrine factor, the synthesis and secretion of which is specifically induced by exercise-induced muscle contraction. Although the discovery of irisin is relatively recent, its role in affecting bone density and cartilage homeostasis has been reported. Here, we review the production and structural characteristics of irisin and discuss the effects of the different types of exercise involved in the current study on irisin and the role of irisin in anti-aging. In addition, the role of irisin in the regulation of bone mineral density, bone metabolism, and its role in chondrocyte homeostasis and metabolism is reviewed. A series of studies on irisin have provided new insights into the mechanisms of exercise training in improving bone density, resisting cartilage degeneration, and maintaining the overall environmental homeostasis of the joint. These studies further contribute to the understanding of the role of exercise in the fight against osteoarthritis and will provide an important reference and aid in the development of the field of osteoarthritis prevention and treatment.

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Circulating irisin is linked to bone mineral density in geriatric Chinese men

Cited by 14 publications

References 16 publications

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

Role of the Myokine Irisin on Bone Homeostasis: Review of the Current Evidence

The Role of Irisin in Exercise-Mediated Bone Health

Exercise-induced modulation of myokine irisin in bone and cartilage tissue—Positive effects on osteoarthritis: A narrative review

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