Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

Gan, Wenyuan; Chen, Wenli; Li, Tianyu; Shao, Danni; Xü, Fang; Huo, Shanshan; Li, Chenchen; Yang, Zhenhua; Zeng, Xingruo

doi:10.1007/s11255-021-03000-8

Cited by 14 publications

(8 citation statements)

References 38 publications

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“…Afterward, there are many animal experiments and clinical studies have provided evidence regarding the association between circulating irisin levels and health status. Irisin levels were reported to be decreased in patients with cardiovascular disease, hypertension, and chronic kidney disease [30][31][32]. Moreover, circulating irisin levels were found to be lower in dialysis patients than in non-dialysis patients [31,32].…”

Section: Discussionmentioning

confidence: 99%

“…Irisin levels were reported to be decreased in patients with cardiovascular disease, hypertension, and chronic kidney disease [30][31][32]. Moreover, circulating irisin levels were found to be lower in dialysis patients than in non-dialysis patients [31,32]. On the one hand, numerous studies indicate that exercise-induced irisin production helps to improve glucose and lipid metabolism, ameliorating obesity-driven in ammation, metabolic syndrome, and tissue injury [6-10].…”

Section: Discussionmentioning

confidence: 99%

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Irisin promotes intestinal epithelial cell proliferation via Wnt/β-Catenin and focal adhesion kinase signaling pathways

Gaowa,

Leangpanich,

Jeong

et al. 2024

Preprint

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The regeneration of epithelia is crucial for maintaining intestinal homeostasis. Irisin is exercise-induced hormone that was originally found to be secreted by skeletal muscles and which regulates energy metabolism. Recent studies have revealed that irisin protects against gut inflammation. However, the direct effects of irisin on intestinal epithelial cell remains to be elucidated. In this study, mouse intestinal organoids were used to assess the effects of irisin on the proliferation of intestinal epithelial cells. The size and budding morphologies of organoids were studied by confocal microscopy. Gene expression levels were assessed by quantitative real-time PCR and Western blotting. The cell surface expressions of integrins were determined by immunofluorescent cytometry. Irisin markedly stimulated the growth of intestinal organoids, thereby increasing the surface areas and budding phenotypes of the organoids. Interestingly, irisin significantly increased the expression of both β-catenin and the transcriptional targets of Wnt signaling Lgr5 and Cyclin D1. Furthermore, irisin induced the activation of focal adhesion kinase (FAK) signaling, whereas a FAK inhibitor suppressed the cell proliferation. Taken together, irisin promotes epithelial cell proliferation via Wnt/β-Catenin and FAK signaling pathways in intestinal organoids, suggesting that irisin may be a promising therapeutic for intestinal epithelial regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-Catenin and focal adhesion kinase signaling pathways

Gaowa,

Leangpanich,

Jeong

et al. 2024

Preprint

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“…The serum irisin level of patients in CKD stage 4 was significantly reduced compared with CKD stage 2 patients [ 21 ]. The lowest irisin concentrations were observed in patients with ESRD [ 19 ], and furthermore, irisin levels were lower in dialysis patients than in nondialysis patients and lower than in healthy controls [ 22 ]. Irisin is produced within muscles, and total muscle volume can affect the irisin level with the progression of kidney failure; a gradual decrease in muscle mass is observed, and it is one possible mechanism of the reduction of the irisin level.…”

Section: Discussionmentioning

confidence: 99%

Increased Circulating Irisin Levels in Kidney Transplant Patients: Is There a Connection with Glycaemic Control?

Bzoma,

Kuchta,

Sałaga-Zaleska

et al. 2024

IJMS

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Irisin is a myokine with potential effects on glucose metabolism and the development of diabetes in humans. We analysed irisin serum levels (ISL) in 47 patients without diabetes before and 1, 2, 3, 4 and 5 weeks after kidney transplantation (KTx). All measurements of irisin before KTx levels were lower than 25 ng/mL (median 8.4 ng/mL). We found an outstanding increase in ISL measured after KTx, reaching more than 1000 times in 44% of patients (HIL—high irisin level group). The increase appeared at the first measurement (one week after KTx). Factors connected to the large growth of ISL were, i.e., BMI > 30 (p = 0.04) and subsequent KTx—second and third (p < 0.001). The global mean blood glucose level during the first two weeks after KTx was significantly lower in the HIL group (p = 0.002), the same as the day-by-day analysed mean fasting and postprandial serum glucose in the first days after KTx. In 12 months of observation, diabetes requiring insulin therapy occurred in the HIL group at a rate of 19%, while in the rest of the patients, the rate was 27%, p = 0.526. Irisin levels increase significantly in some patients after kidney transplantation, accompanied by lower blood glucose levels in the early post-transplant period. Whether an increase in irisin levels results in better glycaemic control remains questionable and requires further research, as well as the relationship between irisin levels and the occurrence of PTDM.

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“…Additionally, the performed statistical analysis showed that BMI, HbA1c and creatinine were the most strongly and significantly correlated with irisin concentration. Recent studies indicate the presence of a strong association between CKD and lowered irisin levels [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

et al. 2022

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Irisin is a cytokine involved in many metabolic pathways occurring, among others, in muscles, adipose tissue and liver. Thus, fluctuations in irisin levels are suggested to be related to metabolic diseases. Therefore, the purpose of our study was to evaluate whether irisin may be associated with non-alcoholic fatty liver disease (NAFLD). A total of 138 patients (70/68 male/female, mean age 65.61 ± 10.44 years) were enrolled in the study. The patients were assigned to the NAFLD group (n = 72, including 46 patients with type 2 diabetes (T2DM]) and the group without NAFLD (n = 66, 31 patients with T2DM). NAFLD was diagnosed based on ultrasound examination, Hepatic Steatosis Index (HSI) and Fatty Liver Index. Baseline anthropometric, blood pressure and biochemical parameters were collected. The serum irisin level was determined using an ELISA test. We observed that NAFLD was associated with an increased concentration of irisin. Moreover, Spearman correlations and linear regression analysis revealed that irisin level correlates with some anthropometric and biochemical parameters such as body mass index, glycated hemoglobin, aspartic aminotransferase, creatinine and urea. Logistic regression analysis depicted that odds for NAFLD increase 1.17 times for each 1 μg/mL rise of irisin concentration. Finally, ROC analysis showed that the concentration of irisin possesses a discriminate capacity for NAFLD and optimal cut points concentration could be designed. The risk of NAFLD in the subgroup with irisin concentration above 3.235 μg/mL was 4.57 times higher than in patients with the lower concentration of irisin. To conclude, the obtained results suggest that irisin concentration is associated with some anthropometric and biochemical parameters and should be further investigated toward its usage as a diagnostic biomarker of NAFLD.

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Circulating irisin level in chronic kidney disease patients: a systematic review and meta-analysis

Cited by 14 publications

References 38 publications

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-Catenin and focal adhesion kinase signaling pathways

Irisin promotes intestinal epithelial cell proliferation via Wnt/β-Catenin and focal adhesion kinase signaling pathways

Increased Circulating Irisin Levels in Kidney Transplant Patients: Is There a Connection with Glycaemic Control?

Irisin Is Related to Non-Alcoholic Fatty Liver Disease (NAFLD)

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