Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes

Monteleone, Palmiero; Lieto, Andrea Di; Tortorella, Alfonso; Longobardi, Nicola; Maj, Mario

doi:10.1016/s0165-1781(00)00144-x

Cited by 109 publications

(70 citation statements)

References 29 publications

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“…8,10,11 Because BW, body composition and REE values were very similar in all subjects of this study, and since the physical activity was most likely comparable, a similar overall energy intake has to be assumed. In addition, since in all cases BW was essentially stable in all cases, all patients have to be considered in energy balance.…”

Section: Discussionmentioning

confidence: 99%

“…5 -7 Furthermore, a clear-cut decrease of serum leptin concentration was observed in bulimia nervosa patients despite a normal or nearly normal body weight, indicating that factors other than body fat stores may play a role in regulating leptin production. 8,9 It has therefore been suggested that in anorexia and bulimia nervosa patients a reduced leptin level in absolute or relative terms could explain the increased hunger sensation and could compel bulimic patients to binge eating. 5 -9 The few published investigations on leptin concentration in binge eating disorder (BED) obese patients provide conflicting results.…”

Section: Introductionmentioning

confidence: 99%

“…10 In contrast, other researches showed higher leptin concentrations in BED obese patients than is normally expected for their body weight, indicating that plasma leptin might be a sensitive marker of metabolic changes occurring during bingeing episodes, and that an increased leptin value with an impaired sensitivity to the increased circulating leptin could be involved in the pathogenesis and=or in the maintenance of bingeing behavior. 8,11 In order to ascertain the relationships between leptin and eating pattern in obese patients, this investigation sought to measure the serum leptin concentrations in both BED and non-BED obese patients and to correlate data to individual food-and shape-attitudes and to the patients' weight fluctuations.…”

Section: Introductionmentioning

confidence: 99%

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Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

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BACKGROUND:In steady-state conditions serum leptin concentration is directly related to body fat stores, but is also affected by changes in energy balance. This cross-sectional study investigated the serum leptin concentrations of severely obese patients with binge eating disorder (BED), in whom body fat was greater than normal and, because of eating pattern, rapid and repeated changes in energy balances took place. METHODS: A group of BED obese patients was compared to a group of obese patients with a regular eating pattern with the same body weight, body composition and resting energy expenditure. Serum leptin was measured and the eating attitudes were evaluated by Eating Inventory and Eating Disorder Inventory. RESULTS: In these patients serum leptin concentrations were only weakly correlated to body mass. Furthermore, in BED obese patients serum leptin concentration was higher than in their non bingeing counterparts. CONCLUSIONS: In obese patients both body fat size and eating behavior influence serum leptin concentration, but BED patients binge eating is not triggered by a low leptin value.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum leptin concentration in obese patients with binge eating disorder

Adami

Campostano²,

Cella

et al. 2002

Int J Obes

View full text Add to dashboard Cite

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“…It is possible that a longer weight recuperation period is necessary for this to occur. Some studies suggest that body mass index (BMI) is the most important control factor for the secretion of leptin in situations of modified food intake (45) and that there is a loss in circadian rhythms in patients with AN (46). One aspect of great interest is whether leptin is necessary for the recovery of menstruation in these patients (47); however, more investigation is necessary in order to answer this question.…”

Section: Hypothalamic -Pituitary-ovarian Axismentioning

confidence: 99%

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Argente

2002

European Journal of Endocrinology

146

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Anorexia nervosa (AN) is a chronic childhood psychiatric illness that involves a reduction in caloric intake, loss of weight and amenorrhea, either primary or secondary. The diagnostic criteria for AN have been established by the American Psychiatric Association. The prevalence of this disease amongst adolescents and young adults is between 0.5 and 1% and the incidence of new cases per year is approximately 5-10/100 000 between 15 and 19 years of age. A number of endocrine and metabolic disturbances have been described in patients with AN including amenorrhea-oligomenorrhea, delayed puberty, hypothyroidism, hypercortisolism, IGF-I deficiency, electrolyte abnormalities, hypoglycemia and hypophosphatemia, among others. In addition to prolonged amenorrhea, osteopenia and osteoporosis are the most frequent complications leading to clinically relevant fractures and increased fracture risk throughout life. Patients exhibit an alteration in the hypothalamic -pituitary -gonadal axis, which is responsible for the menstrual disorders. The increase in gonadotropin secretion that can be observed after ponderal recuperation suggests that malnutrition could be the most important mechanism involved in the decrease in gonadotropin secretion. The loss of fat tissue as a consequence of nutrient restriction has been associated with hypoleptinemia and abnormal secretion of peptides implicated in food control (neuropeptide Y, melanocortins and corticotropin-releasing factor, among others). A review of the endocrine abnormalities, disturbances in neurotransmitters, as well as a detailed analysis of bone markers and bone mineral density in patients with AN is described.

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“…While circulating leptin and PRL are both decreased in anorexia nervosa (32), and these hormone levels decline with age (33), there are no correlations found between the two hormones. In this study, no distinct influences of exogenously administered leptin on serum PRL levels were observed.…”

Section: Discussionmentioning

confidence: 87%

The effects of human leptin fragment(126-140) on pituitary functions in man

Hanew

2003

European Journal of Endocrinology

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Objective: The effects of human leptin fragment(126 -140) on pituitary function in eight healthy, nonobese men were studied. Methods and design: The effects of the fragment on spontaneous secretion of pituitary hormones and endogenous leptin, as well as on GHRH-induced GH secretion were examined. Results: After the administration of the fragment (50 mg i.v. for 150 min), the mean nadir value and 45 min value were significantly lower than that of the control study. Endogenous leptin levels did not decrease significantly following the administration of the leptin fragment. Other pituitary hormones were not affected by the fragment. The area under the curve of the GH response to GHRH(1 -44)NH 2 (10 mg, i.v. from 0 to 75 min) was also significantly inhibited by the combined administration of the leptin fragment (100 mg i.v. from 2 30 to 75 min) (P , 0.001). Three subjects were re-examined with larger doses of the leptin fragment (200 -400 mg), and even greater GH suppression was observed. Conclusions: These results indicate that human leptin fragment(126 -140) has an inhibitory role in GH secretion, since when administered exogenously this fragment significantly suppressed spontaneous and, in a dose-response manner, GHRH-induced GH secretion. Clear effects of the fragment on other pituitary hormones and an inhibitory effect on endogenous leptin secretion were not observed in this study.

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Circulating leptin in patients with anorexia nervosa, bulimia nervosa or binge-eating disorder: relationship to body weight, eating patterns, psychopathology and endocrine changes

Cited by 109 publications

References 29 publications

Serum leptin concentration in obese patients with binge eating disorder

Serum leptin concentration in obese patients with binge eating disorder

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

The effects of human leptin fragment(126-140) on pituitary functions in man

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