Circulating Long Non-Coding RNA GAS5: A Non-Invasive Molecular Marker for Prognosis, Response to Treatment and Survival in Non-Small Cell Lung Cancer

Mourgi, Majed Al; Askary, Ahmad El; Gharib, Amal F.; Alzahrani, Rajab; Banjer, Hamsa Jameel; Elsawy, Wael H.; Ghamdi, Abd El-Rahman Al; Raafat, Nermin

doi:10.1080/07357907.2021.1928167

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…These are represented as serum biomarkers of novel diagnostic and prognostic value in the patients with NPC [ 134 ]. In addition to these, PVT1 (Plasmacytoma variant translocation 1), GAS5 (Growth arrest specific transcript 5), H19 are also suggested to be used as biomarkers within bio-fluids in patients of melanoma, breast cancer and non-small cell lung cancer [ 135 – 137 ]. Besides acting as molecular markers of diagnosis as well as prognosis, the expression of lncRNAs can also predict the sensitivity to radio- and chemo-therapy.…”

Section: Lncrnas As Clinical Utility Targetsmentioning

confidence: 99%

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

et al. 2023

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Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries and the leading cause of cancer deaths in 36 countries. There is, therefore, a need to come up with novel diagnostic and therapeutic targets. Long non-coding RNAs (lncRNAs) play a remarkable role in genome regulation and contribute significantly to several developmental and disease pathways. The deregulation of lncRNAs is often observed in cancer patients, where they are shown to affect multiple cellular processes, including cell cycle, apoptosis, angiogenesis, and invasion. Many lncRNAs are found to be involved in the pathogenesis as well as progression of cervical cancer and have shown potency to track metastatic events. This review provides an overview of lncRNA mediated regulation of cervical carcinogenesis and highlights their potential as diagnostic and prognostic biomarkers as well as therapeutic targets for cervical cancer. In addition, it also discusses the challenges associated with the clinical implication of lncRNAs in cervical cancer.

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Section: Lncrnas As Clinical Utility Targetsmentioning

confidence: 99%

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

et al. 2023

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“…In recent years, LncRNA-GAS5 (growth arrest-specific transcript 5) has been reported as a tumor suppressor lncRNA in various human cancers. For instance, its downregulation has been observed in epithelial ovarian cancer, cervical cancer, lung cancer, and gliomas ( 23 – 27 ). GAS5 directly interacts with the WW structural domain of YAP to inhibit colorectal cancer progression in vitro and in vivo ( 28 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA GAS5 represses stemness and malignancy of gliomas via elevating the SPACA6-miR-125a/let-7e Axis

Ren²,

Zhao³

et al. 2022

Front. Oncol.

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Glioblastoma (GBM) is a highly invasive neurological malignancy with poor prognosis. LncRNA-GAS5 (growth arrest-specific transcript 5) is a tumor suppressor involved in multiple cancers. In this study, we explored the clinical significance, biological function, and underlying mechanisms of GAS5 in GBM. We showed that lncRNA-GAS5 expression decreased in high-grade glioma tissues and cells, which might be associated with poor prognosis. GAS5 overexpression lowered cell viability, suppressed GBM cell migration and invasion, and impaired the stemness and proliferation of glioma stem cells (GSCs). We further discovered that GAS5 inhibited the viability of glioma cells through miR-let-7e and miR-125a by protecting SPACA6 from degradation. Moreover, GAS5 played an anti-oncogenic role in GBM through the combined involvement of let-7e and miR-125a in vivo and in vitro. Notably, these two miRNAs block the IL-6/STAT3 pathway in tumor tissues extracted from a xenograft model. Taken together, our study provides evidence for an important role of GAS5 in GBM by affecting the proliferation and migration of GSCs, thus providing a new potential prognostic biomarker and treatment strategy for GBM.

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Diagnostic Accuracy of Exosomal Long Noncoding RNAs in Diagnosis of NSCLC: A Meta-Analysis

Song,

Duan,

Dong

2024

Mol Diagn Ther

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Circulating Long Non-Coding RNA GAS5: A Non-Invasive Molecular Marker for Prognosis, Response to Treatment and Survival in Non-Small Cell Lung Cancer

Cited by 6 publications

References 40 publications

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives

LncRNA GAS5 represses stemness and malignancy of gliomas via elevating the SPACA6-miR-125a/let-7e Axis

Diagnostic Accuracy of Exosomal Long Noncoding RNAs in Diagnosis of NSCLC: A Meta-Analysis

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