Circulating long non-coding RNA signature in knee osteoarthritis patients with postoperative pain one-year after total knee replacement

Giordano, Rocco; Petersen, Kristian Kjær; Santoro, Massimo; Pazzaglia, Costanza; Simonsen, Ole; Valeriani, Massimiliano; Arendt-Nielsen, Lars

doi:10.1515/sjpain-2021-0069

Cited by 9 publications

(10 citation statements)

References 59 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…( 64,65 ) MALAT1 itself appears to inhibit senescence, evident from experiments where MALAT1 siRNA increased senescent cell numbers in vitro. ( 64 ) Importantly, MALAT1 decreases in patients with osteoarthritis, ( 66 ) in patients with postmenopausal osteoporosis, ( 67 ) and in mouse muscle atrophied with aging, hindlimb unloading, and glucocorticoid treatment ( 63,68 ) (Fig. 3).…”

Section: Discussionmentioning

confidence: 97%

Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

et al. 2022

View full text Add to dashboard Cite

Extracellular vesicles (EVs), including exosomes and microvesicles, are released by numerous cell types. EVs are now acknowledged as playing a critical role in cell-cell communication in healthy aging as well as in age-related diseases. Recently it was shown that senescence, a key hallmark of aging, increases the secretion of EVs. Moreover, EVs can transport proteins and microRNAs (miRNAs) that are key components of the senescence-associated secretory phenotype (SASP). Here we review evidence that SASP-related miRNAs are involved in musculoskeletal degeneration with aging. Specifically, senescence-related miRNAs are elevated in EVs released by skeletal muscle myocytes and fibro-adipogenic progenitor cells with aging and disuse atrophy, respectively. Many of these same senescence-related miRNAs are detected in EVs from the synovial fluid of patients with osteoarthritis, and these miRNAs can contribute to cartilage degeneration. Finally, senescence-associated miRNAs are secreted from bone marrow-derived stem (stromal) cells impacting neighboring hematopoietic stem cells and circulating in the blood. The senescence-associated miRNA mir-34a, which is known to target Wnt and Notch pathways as well as the cell survival factors Sirt1 and Bcl2, is detected in EVs from human and animal subjects with muscle atrophy, bone loss, and osteoarthritis. These findings suggest that suppressing the secretion of EV-derived, senescence-related miRNAs, such as miR-34a, or increasing levels of competing endogenous long noncoding RNAs, such as MALAT1 that inhibit miR-34a, may help to improve musculoskeletal function with aging.

show abstract

Section: Discussionmentioning

confidence: 97%

Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Preoperative dysregulation of circulating microRNAs and long non-coding RNA (lncRNA) related to the inflammatory processes may serve as predictive biomarkers of pain outcome after surgery. 33 , 34 The hookwire localization may trigger releases of inflammatory mediators. In this study, we did not measure preoperative serum levels of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Does Preoperative Hookwire Localization Influence Postoperative Acute and Chronic Pain After Video-Assisted Thoracoscopic Surgery: A Prospective Cohort Study

Kong

Gao

Zhang

et al. 2023

JPR

View full text Add to dashboard Cite

This study aimed to investigate whether preoperative computerized tomography-guided hookwire localization-associated pain could affect acute and chronic postsurgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgery (VATS). Methods: We enrolled 161 adult patients who underwent elective VATS; sixty-nine patients experienced hookwire localization (Group A) and 69 did not (Group B). Group A was further subdivided into the multiple localization group (n=35, Group A multiple ) and the single localization group (n=34, Group A single ) according to the number of hookwires. The numerical rating scale (NRS) was used preoperatively, during recovery at the post-anesthesia care unit (PACU), and the first two days, 3 and 6 months postoperatively. Furthermore, multivariate regression analysis was used to identify the risk factors associated with CPSP. The postoperative adverse events, length of hospital stay, and satisfaction in pain management were also recorded. Results:The incidence and severity of acute postoperative pain were similar between Group A and Group B (p > 0.05). The incidence (56.5% vs 30.4%, p = 0.002) and the NRS scores (2.0 [2.0-3.0] vs 1.0 [1.0-2.0], p = 0.011) for CPSP were significantly higher in Group A than in Group B at 3 months postoperatively. On subgroup analysis, compared with Group A single , the intensity of CPSP (2.0 [2.0-3.0] vs 2.0 [1.0-2.0], p = 0.005) in Group A multiple was slightly higher at 3 months postoperatively. Conversely, the CPSP incidence (60.0% vs 29.4%, p = 0.011) was significantly higher at 6 months postoperatively in Group A multiple . The multivariate regression analysis further validated hookwire localization as a risk factor for CPSP (odds ratio: 6.199, 95% confidence interval 2.049-18.749, p = 0.001). Patient satisfaction relating to pain management at 3 months postoperatively was lower in Group A (p = 0.034). Conclusion:The preoperative pain stress of hookwire localization increased the incidence and intensity of CPSP rather than acute pain at 3 months postoperatively, especially in patients with multiple hookwires.

show abstract

“…Additionally, a study of 20 preoperative KOA patients revealed that serum levels of MZF1-AS1, MALAT1, and LOC100287846 were lower preoperatively in the chronic postoperative pain group ( n = 10) compared to the normal postoperative pain recovery group ( n = 10). 56 Thus, in addition to miRNAs, biofluid lncRNAs may also be good candidate biomarkers for OA diagnosis, prognosis, and therapeutic efficacy tracking. More extensive studies investigating lncRNAs, their links to individual miRNAs, and changes with OA stage, symptoms and outcomes are necessary.…”

Section: Emerging Molecular Biomarkersmentioning

confidence: 99%

Emerging molecular biomarkers in osteoarthritis pathology

Sandhu

Rockel

Lively

et al. 2023

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common form of arthritis resulting in joint discomfort and disability, culminating in decline in life quality. Attention has been drawn in recent years to disease-associated molecular biomarkers found in readily accessible biofluids due to low invasiveness of acquisition and their potential to detect early pathological molecular changes not observed with traditional imaging methodology. These biochemical markers of OA have been found in synovial fluid, blood, and urine. They include emerging molecular classes, such as metabolites and noncoding RNAs, as well as classical biomarkers, like inflammatory mediators and by-products of degradative processes involving articular cartilage. Although blood-based biomarkers tend to be most studied, the use of synovial fluid, a more isolated biofluid in the synovial joint, and urine as an excreted fluid containing OA biomarkers can offer valuable information on local and overall disease activity, respectively. Furthermore, larger clinical studies are required to determine relationships between biomarkers in different biofluids, and their impacts on patient measures of OA. This narrative review provides a concise overview of recent studies of OA using these four classes of biomarkers as potential biomarker for measuring disease incidence, staging, prognosis, and therapeutic intervention efficacy.

show abstract

Circulating long non-coding RNA signature in knee osteoarthritis patients with postoperative pain one-year after total knee replacement

Cited by 9 publications

References 59 publications

Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

Extracellular Vesicles as Communicators of Senescence in Musculoskeletal Aging

Does Preoperative Hookwire Localization Influence Postoperative Acute and Chronic Pain After Video-Assisted Thoracoscopic Surgery: A Prospective Cohort Study

Emerging molecular biomarkers in osteoarthritis pathology

Contact Info

Product

Resources

About