Circulating microRNA-23b as a new biomarker for rheumatoid arthritis

Liu, Xi; Ni, Su; Li, Chenkai; Xu, Nanwei; Chen, Wenyang; Wu, Min; Wijnen, André J. van; Wang, Yuji

doi:10.1016/j.gene.2019.06.001

Cited by 41 publications

(30 citation statements)

References 41 publications

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“…Nevertheless, Sun et al [ 50 ] noted that miR-145 is upregulated in oligoarthritis comparing to polyarthritis and SoJIA. Besides, miR-23b appeared to be overexpressed in RA patients with the relevant titer of antinuclear antibodies (ANA) [ 51 ]. Given that the variability of gene expression may be correlated with a child's age at disease onset [ 52 ], such findings may contribute to the task of defining early onset ANA-positive arthritis which is planned to be discerned in the upcoming reclassification of JIA [ 53 ].…”

Section: Other Mirnas Possibly Relevant For Jiamentioning

confidence: 99%

“…miRNAs as a class of molecules are not free of such limitations. Despite the potential usefulness of miR-23b in diagnosing rheumatic diseases, this molecule is also related to fibrogenesis within chronic liver injury and diabetic nephropathy [ 51 ]. Nevertheless, there are several miRNAs which have already been tested whether they are specific for systemic autoimmune diseases.…”

Section: Challenges For Mirna In Pediatric Rheumatologymentioning

confidence: 99%

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The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Orczyk

Smolewska

2021

Journal of Immunology Research

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Small, noncoding sequences of ribonucleic acid called microRNAs (miRNAs, miR) are functioning as posttranscriptional regulators of gene expression. As they draw increasing attention of rheumatologists, there is a growing body of evidence concerning specific molecules that may affect the long-term care of patients with inflammatory arthritides. Findings involving children with juvenile idiopathic arthritis (JIA) are still limited though. The aim of the study was to browse the available data on microRNAs which may be utilized as potential biomarkers helpful in diagnosing and monitoring JIA patients. The review contains a brief summary on the most studied sequences: miR-16, miR-125a-5p, miR-146a, miR-155, and miR-223. It is complemented with other miRNAs possibly relevant for JIA (miR-145, miR-23b, miR-27a, and miR-204) and discussion on challenges for using miRNAs in pediatric rheumatology (particularly, issues regarding specificity of biomarkers and measurements involving synovial fluid).

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Section: Other Mirnas Possibly Relevant For Jiamentioning

confidence: 99%

Section: Challenges For Mirna In Pediatric Rheumatologymentioning

confidence: 99%

The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Orczyk

Smolewska

2021

Journal of Immunology Research

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“…In addition, an increase in serum miR-194-5p levels is associated with disease recurrence (90). The Serum expression of miR-23b which positively correlated with ESR, CRP and DAS28 are significantly up-regulated after treatment, indicating that miR-23b is a dual marker of disease activity and prognosis (91). miR-96-5p, miR-134-5p, miR-140-3p, miR-627-5p are not only diagnostic markers for RA, but also indicates the disease activity (92).…”

Section: Blood and Serum-based Mirnas Provided Novel Opportunity To Tmentioning

confidence: 99%

Epigenetic Regulation Mediated by miRNA in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

Guo¹,

Chang²,

Xu³

et al. 2020

Preprint

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Contribution:micro-RNA (miRNA) has been demonstrated to play important roles in the transcriptome regulation and disease development including cancer and autoimmune disease such as rheumatoid arthritis. However, a comprehensive role of miRNAs in rheumatoid arthritis (RA) including immune system differentiation and interaction with terminal cells like T cells, fibroblast-like synoviocytes (FLS), osteoblast and osteoclast still unclear. In this review, we have provided a thorough summary on the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention and prognosis. We summarized the blood and cell-free miRNA biomarkers which provided novel opportunity to work together with rheumatoid factors (RF), anti-CCP to provide accurate diagnosis and prognosis especially for seronegative patients. Finally, miRNAs were showed as promising biomarker to indicate the DMRDS and immunotherapy efficiency, drug response and resistance. What's more, autotherapeutic effect of miRNA intervention provided promising to develop miRNA based rheumatoid arthritis drugs. Overall, current evidence supports miRNAs as the interesting targets to better understand the pathogenetic mechanism and therapeutic intervention of rheumatoid arthritis.Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 15 April 2020 Abstract micro-RNA (miRNA) has been demonstrated to play important roles in the transcriptome regulation and disease development including cancer and autoimmune disease such as rheumatoid arthritis. However, a comprehensive map on how the mRNAs regulate transcripts, pathways, immune system differentiation and interaction with terminal cells like T cells, fibroblast-like synoviocytes (FLS), osteoblast and osteoclast still unknown. In this review, we have provided a thorough summary on the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention and prognosis. Numerous miRNAs were found abnormally expressed in rheumatoid arthritis relevant cells and regulated the target genes and pathways like NF-κB, Fas-FasL, JAK-STAT, IRE1-RIDD, mTOR pathway. In addition, miRNA act as gene expression regulators affect the T cell differentiate to different cell types including Th17 and T-reg cells which provide promising gene therapy target to regulate immune systems in rheumatoid arthritis. We also summarized interesting diagnosis and prognosis roles of blood and cell-free based miRNAs which provided novel opportunity to work together with rheumatoid factors (RF), anti-CCP to provide accurate diagnosis and prognosis especially for seronegative patients. Furthermore, functional genetic variants in miR-499 and miR-146a explained part of missing susceptibility of rheumatoid arthritis. Finally, miRNAs were showed as promising biomarker to indicate the DMRDS and immunotherapy efficiency, drug response and resistance. What's more, autotherapeutic effect of miRNA intervention provided promising to develop miRNA based rheumatoid arthritis drugs. Overall, current evidence supports miRNAs as the inter...

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“…Increase in serum miR-194-5p levels is associated with disease recurrence (Fernandez-Ruiz et al, 2018). Serum expression of miR-23b, which positively correlates with ESR, CRP, and DAS28, is significantly up-regulated after appropriate treatment, indicating that miR-23b is a dual marker of disease activity and prognosis (Liu et al, 2019b). Similarly, are not only diagnostic markers for RA, but also reflect disease activity (Ormseth et al, 2020b).…”

Section: Blood and Serum-circulating Mirnas Provide Novel Opportunitimentioning

confidence: 99%

Epigenetic Regulation Mediated by microRNAs in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

Guo¹,

Chang²,

Xu³

et al. 2020

Preprint

View full text Add to dashboard Cite

MicroRNAs (miRNAs) play crucial roles in the regulation of the transcriptome and development of diseases including cancer and autoimmune diseases, such as rheumatoid arthritis (RA). Currently, a comprehensive map, illustrating how miRNAs regulate transcripts, pathways, immune system differentiation, and their interaction with terminal cells, such as T cells, fibroblast-like synoviocytes (FLS), osteoblasts, and osteoclasts, is still missing. In this review, we provide a thorough summary of the roles of miRNAs in the susceptibility to pathogenesis, diagnosis, therapeutic intervention, and prognosis of RA. Numerous miRNAs are abnormally expressed in cells involved in RA, and regulate target genes and pathways including the NF-κB, Fas-FasL, JAK-STAT, IRE1-RIDD, and mTOR pathways. By regulating gene expression, miRNAs affect T cell differentiation to diverse cell types, including Th17 and T-reg cells, and thus constitute promising gene therapy targets to modulate the immune system in RA. We summarize the diagnostic and prognostic potential of blood-circulating and cell-free miRNAs, highlighting the novel opportunities to combine these with rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) to provide accurate diagnosis and prognosis, especially for seronegative patients. Furthermore, we outline how functional genetic variants of miR-499 and miR-146a partly explain the unmet susceptibility to RA. Additionally, we review the evidence implicating miRNAs as promising biomarkers of efficiency, response, and resistance to disease-modifying anti-rheumatic drugs (DMRDs) and immunotherapy. Finally, we discuss the autotherapeutic effect of miRNA intervention as a step toward the development of miRNA-based anti-RA drugs. Collectively, the current evidence supports miRNAs as interesting targets to better understand the pathogenetic mechanisms of RA and design more efficient therapeutic interventions.

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Circulating microRNA-23b as a new biomarker for rheumatoid arthritis

Cited by 41 publications

References 41 publications

The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

The Potential Importance of MicroRNAs as Novel Indicators How to Manage Patients with Juvenile Idiopathic Arthritis More Effectively

Epigenetic Regulation Mediated by miRNA in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

Epigenetic Regulation Mediated by microRNAs in the Susceptibility and Pathogenesis of Rheumatoid Arthritis

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