Circulating MicroRNA Is a Biomarker of Biliary Atresia

Zahm, Adam M.; Hand, Nicholas J.; Boateng, LaTasha A.; Friedman, Joshua R.

doi:10.1097/mpg.0b013e318264e648

Cited by 56 publications

(52 citation statements)

References 25 publications

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“…32,122,123 In biliary atresia, circulating levels of the miR-200b/429 cluster are elevated in infants and have promising diagnostic clinical potential. 127 Interestingly, exosomal miRNA expression pattern is unique to liver diseases and varies between grade and stages of liver disease, which emphasizes their potential as diagnostics biomarkers. 128 Moreover, circulating miR-122 could be used as a general marker of liver injury and might have better sensitivity than alanine aminotransferase.…”

Section: Circulating Mirnas As Biomarkers Of Diseasementioning

confidence: 99%

MicroRNAs in liver disease

Szabó

Bala

2013

Nat Rev Gastroenterol Hepatol

544

467

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Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and increasing evidence suggests that they have a role in liver pathology. This Review summarizes advances in the field of miRNAs in liver diseases, inflammation and cirrhosis. MicroRNA-122, the most abundant miRNA in hepatocytes, has well-defined roles in HCV replication, and data indicate that it also serves as a viable therapeutic target. The role of miR-122 is also emerging in other liver diseases. Ample evidence exists for the important regulatory potential of other miRNAs in conditions associated with liver inflammation related to alcohol use, the metabolic syndrome or autoimmune processes. In addition, a broad array of miRNAs have been associated with the development of liver fibrosis both in animal models and human studies. The significance of the function and cellular distribution of miRNAs in the liver and the potential of miRNAs as a means of communication between cells and organs is discussed as well as the emerging utility of circulating miRNAs as biomarkers of different forms of liver damage and as early markers of disease and progression in hepatocellular carcinoma. Importantly, miRNA modulation in the liver represents a new therapeutic approach in the treatment armamentarium of hepatologists in the future.

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Section: Circulating Mirnas As Biomarkers Of Diseasementioning

confidence: 99%

MicroRNAs in liver disease

Szabó

Bala

2013

Nat Rev Gastroenterol Hepatol

544

467

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“…As in the study conducted in CFLD, serum miRNA profiles have been evaluated using PCR arrays in children with BA versus a cholestatic control group including children diagnosed with non-BA cholestatic diseases such as Alagille syndrome or choledocholithiasis (Table 3) [144]. Eleven miRNAs were found to be differentially expressed between the two groups and nine confirmed by qRT-PCR in independent cohorts.…”

Section: Circulatory Mirnas As Biomarkers In Paediatric Liver Diseasementioning

confidence: 99%

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

Calvopina

Coleman

Lewindon

et al. 2016

IJMS

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MicroRNAs (miRNAs) are short non-coding RNAs involved in biological and pathological processes of every cell type, including liver cells. Transcribed from specific genes, miRNA precursors are processed in the cytoplasm into mature miRNAs and as part of the RNA-induced silencing complex (RISC) complex binds to messenger RNA (mRNA) by imperfect complementarity. This leads to the regulation of gene expression at a post-transcriptional level. The function of a number of different miRNAs in fibrogenesis associated with the progression of chronic liver disease has recently been elucidated. Furthermore, miRNAs have been shown to be both disease-and tissue-specific and are stable in the circulation, which has led to increasing investigation on their utility as biomarkers for the diagnosis of chronic liver diseases, including those in children. Here, we review the current knowledge on the biogenesis of microRNA, the mechanisms of translational repression and the use of miRNA as circulatory biomarkers in chronic paediatric liver diseases including cystic fibrosis associated liver disease, biliary atresia and viral hepatitis B.

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“…In a recent study, serum microRNAs were assessed for their utility as a diagnostic tool to differentiate BA from other forms of neonatal hyperbilirubinemia [71]. A microRNA array was performed on sera from BA patients and age-and sex- matched indeterminate cholestasis controls.…”

Section: Diagnostic Prognostic and Therapeutic Prospectsmentioning

confidence: 99%

MicroRNAs in Cholangiopathies

et al. 2014

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Cholangiocytes, the cells lining bile ducts, comprise a small fraction of the total cellular component of the liver, yet perform the essential role of bile modification and transport of biliary and blood constituents. Cholangiopathies are a diverse group of biliary disorders with the cholangiocyte as the target cell; the etiopathogenesis of most cholangiopathies remains obscure. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. These small RNAs may not only be involved in the etiopathogenesis of disease, but are showing promise as diagnostic and prognostic tools. In this brief review, we summarize recent work regarding the role of microRNAs in the etiopathogenesis of several cholangiopathies, and discuss their utility as prognostic and diagnostic tools.

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Circulating MicroRNA Is a Biomarker of Biliary Atresia

Cited by 56 publications

References 25 publications

MicroRNAs in liver disease

MicroRNAs in liver disease

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease

MicroRNAs in Cholangiopathies

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