Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer

Heneghan, Helen; Miller, Nicola; Lowery, Aoife; Sweeney, Karl; Newell, John; Kerin, Michael J.

doi:10.1097/sla.0b013e3181cc939f

Cited by 632 publications

(547 citation statements)

References 27 publications

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“…In our pilot study, in addition to circulating mRNAs [64], we detected circulating miRNAs (including miR-141 and miRNA-195) to be present at significantly higher levels (P \ 0.001) in serum from patients recently diagnosed with breast cancer compared to age-and gender-matched healthy volunteers (as yet unpublished). In agreement with our findings, mi-195 and let-7a have recently been reported as at significantly higher levels in blood from breast cancer patients, compared to healthy volunteers [151].…”

Section: Micrornas In Breast Cancersupporting

confidence: 94%

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Friel

Corcoran

Crown

et al. 2010

Breast Cancer Res Treat

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Early detection of cancer is vital to improved overall survival rates. At present, evidence is accumulating for the clinical value of detecting occult tumor cells in peripheral blood, plasma, and serum specimens from cancer patients. Both molecular and cellular approaches, which differ in sensitivity and specificity, have been used for such means. Circulating tumor cells and extracellular nucleic acids have been detected within blood, plasma, and sera of cancer patients. As the presence of malignant tumors are clinically determined and/or confirmed upon biopsy procurement-which in itself may have detrimental effects in terms of stimulating cancer progression/metastases-minimally invasive methods would be highly advantageous to the diagnosis and prognosis of breast cancer and the subsequent tailoring of targeted treatments for individuals, if reliable panels of biomarkers suitable for such an approach exist. Herein, we review the current advances made in the detection of such circulating tumor cells and nucleic acids, with particular emphasis on extracellular nucleic acids, specifically extracellular mRNAs and discuss their clinical relevance.

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Section: Micrornas In Breast Cancersupporting

confidence: 94%

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Friel

Corcoran

Crown

et al. 2010

Breast Cancer Res Treat

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“…It may be possible to improve the discriminative performance by including biomarker risk factors such as microRNAs (Heneghan et al, 2010) or BRCA genes. However, including biomarker is not our aim that is to develop a simple model for screening women for further mammography in resource limited settings like Thailand.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of a Breast Cancer Risk Prediction Model for Thai Women: A Cross-Sectional Study

Anothaisintawee

Teerawattananon²,

Wiratkapun³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…153 Levels of miR in whole blood are much higher than plasma or serum miR levels. 154 Serum and plasma levels of specific miRs are not readily comparable. 155 Given the technical challenges, there are conflicting data regarding up-regulation or downregulation of circulating miR in various pathologies.…”

Section: Future Directionsmentioning

confidence: 99%

MicroRNAs in Liver Disease: Bench to Bedside

Shah

Nelson

Kowdley

2013

Journal of Clinical and Experimental Hepatology

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MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by pairing with partially complementary target sequences in the 3 0 UTRs of mRNAs to promote degradation and/or block translation. Aberrant miR expression is associated with development of multiple diseases including hepatic diseases. The role of miRs in the regulation of gene expression and rapid progress in the field of microRNA research are resulting in momentum toward development of diagnostic markers and novel therapeutic strategies for human liver diseases. Recent studies provide clear evidence that miRs are abundant in the liver and modulate a diverse spectrum of biological functions, thereby supporting an association between alterations of miR homeostasis and pathological liver diseases. Here we review the role of miRs in liver as their physiological and pathological importance has been demonstrated in metabolism, immunity, viral hepatitis, oncogenesis, fatty liver diseases (alcoholic and non-alcoholic), drug-induced liver injury, fibrosis as well as acute liver failure. ( J CLIN EXP HEPATOL 2013;3:231-242)

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Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer

Abstract: These findings suggest that systemic miRNAs have potential use as novel breast cancer biomarkers and may prove useful in clinical management during the perioperative period.

Cited by 632 publications

References 27 publications

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer

Development and Validation of a Breast Cancer Risk Prediction Model for Thai Women: A Cross-Sectional Study

MicroRNAs in Liver Disease: Bench to Bedside

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