2016
DOI: 10.5847/wjem.j.1920-8642.2016.02.001
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Circulating microRNAs as potential biomarkers for diagnosis of congenital heart defects

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Cited by 24 publications
(17 citation statements)
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“…Further studies revealed that diabetic pregnant mice display significant changes in exosomal miRNA profiles compared to normal pregnant mice [73,74]. Additionally, significant differential expression of more than 100 circulating miRNAs, including miR-34a, miR-142-5p, miR-1275, miR-4666a-3p and miR-3664-3p, in the peripheral blood of pregnant women carrying a foetus with abnormal heart development compared to women with normal pregnancy has also been reported [57,75,76]. These differentially expressed miRNAs are functionally predicted to be involved in the regulation of foetal heart development by bioinformatics analysis [24,[75][76][77].…”
Section: Circulating and Exosomal-derived Mirnas In Pregnant Women Wimentioning
confidence: 82%
See 1 more Smart Citation
“…Further studies revealed that diabetic pregnant mice display significant changes in exosomal miRNA profiles compared to normal pregnant mice [73,74]. Additionally, significant differential expression of more than 100 circulating miRNAs, including miR-34a, miR-142-5p, miR-1275, miR-4666a-3p and miR-3664-3p, in the peripheral blood of pregnant women carrying a foetus with abnormal heart development compared to women with normal pregnancy has also been reported [57,75,76]. These differentially expressed miRNAs are functionally predicted to be involved in the regulation of foetal heart development by bioinformatics analysis [24,[75][76][77].…”
Section: Circulating and Exosomal-derived Mirnas In Pregnant Women Wimentioning
confidence: 82%
“…Additionally, significant differential expression of more than 100 circulating miRNAs, including miR-34a, miR-142-5p, miR-1275, miR-4666a-3p and miR-3664-3p, in the peripheral blood of pregnant women carrying a foetus with abnormal heart development compared to women with normal pregnancy has also been reported [57,75,76]. These differentially expressed miRNAs are functionally predicted to be involved in the regulation of foetal heart development by bioinformatics analysis [24,[75][76][77]. Therefore, these results confirm that circulatory exosomes or circulating miRNAs in pregnancy participate in the regulation of foetal heart development, providing new insight into CHD diagnosis, prevention and even treatment.…”
Section: Circulating and Exosomal-derived Mirnas In Pregnant Women Wimentioning
confidence: 91%
“…(1) The pathogenic variants might have been excluded by the filtering strategy. To focus on variants that are sufficiently interpretable to be clinically reported, we limited the analysis to variants predicted to impact a protein sequence, but noncoding or miRNA variants may be contributory (J. Li et al., ; Touma et al., ; Xie, Zhou, Chen, & Ni, ). We also required candidate variants to be of low frequency (<1%) in reference populations.…”
Section: Discussionmentioning
confidence: 99%
“…Что касается аномалии формирования двустворчатого аортального клапана, то Yanagawa [26] продемонстрировал, что для этой категории пациентов характерно подавление экспрессии микроР-НК-141. Некоторые недавние исследования также показали, что повышение уровней микроРНК-22, микроРНК -375, микроРНК-19b и микроРНК-29c у матери связано с наличием ВПС у плода, что позволяет предположить, что концентрация микроРНК в материнской сыворотке может являться потенциальным клиническим биомаркером для раннего неинвазивного выявления ВПС плода [25][26][27][28].…”
Section: значение микрорнк в координации и дисрегуляции морфогенеза фunclassified