Circulating miR-126 is a potential biomarker to predict the onset of type 2 diabetes mellitus in susceptible individuals

Zhang, Tao; Li, Liling; Shang, Qingkun; Lv, Chunfang; Wang, ChangYi; Su, Bing

doi:10.1016/j.bbrc.2015.05.017

Cited by 89 publications

(72 citation statements)

References 26 publications

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“…Our data demonstrated that the expression of circulating miR-126-5p could also be influenced by some traditional cardiovascular risk factors, including aging, DM and hyperlipidemia, which is in accordance with previous studies [23,[32][33][34]. It is worth noting that although these risk factors have been reported to be critically involved in the formation of atherosclerosis, circulating miR-126-5p is a potential independent predictive factor for the severity of cardiovascular artery disease.…”

Section: Discussionsupporting

confidence: 78%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao

Liu

et al. 2016

Cell Physiol Biochem

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Background: Coronary artery disease (CAD) is a major problem worldwide. As an endothelium-enriched microRNA (miRNA), miR-126 has been reported to serve as a potential biomarker of acute myocardial infarction. However, the relationship between miR-126 and the severity of CAD remains unknown. This study was designed to test whether circulating miR-126 levels are associated with the severity of CAD. Methods: The present study enrolled 40 patients who had risk factors for CAD without angiographically significant CAD, and 110 patients presenting with stable angina pectoris, who were validated left main coronary artery disease (LMCA) and/or multi-vessel disease by coronary angiography. The expression levels of plasma miR-126-5p from all enrolled subjects were estimated by quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationships between plasma miR-126-5p levels, number of diseased vessels and the corresponding Synergy between PCI with Taxus and Cardiac surgery (SYNTAX) score were analyzed. Results: The expression of circulating miR-126-5p was affected by some CAD risk factors including aging, dyslipidemia and DM. Furthermore, plasma miR-126-5p levels were significantly down-regulated in CAD patients with multi-vessel disease, higher SYNTAX score, rather than isolated LMCA and low SYNTAX score. Conclusion: Circulating miR-126-5p has emerged as a potential biomarker for complexity and severity of CAD in patients with stable angina pectoris.

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Section: Discussionsupporting

confidence: 78%

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Zhao

Liu

et al. 2016

Cell Physiol Biochem

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“…miR-126-3p is the most extensively studied. It is decreased in circulation in adults with T2DM [19], and may be used to predict development of T2DM [26,27]. In children, plasma levels of miR-126 have been positively associated with BMI and plasma triacylglycerols and very-low-density lipoprotein-cholesterol (VLDL-C) [28].…”

Section: Discussionmentioning

confidence: 99%

Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA

et al. 2016

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We aimed to identify miRNAs whose expression levels in fetal tissues are altered by exposure to a diabetic milieu and elucidate the impact on target protein expression. Gestational diabetes mellitus (GDM) affects both immediate and future disease risk in the offspring. We hypothesized that GDM alters miRNA expression in human umbilical vein endothelial cells (HUVECs) that may influence metabolic processes. A cross-sectional design compared differences in miRNA expression in HUVECs and target protein abundance in placentae between infants of women with GDM (IGDM) and infants born to normoglycaemic controls. miRNAs were identified using microarray profiling and literature review and validated by quantitative PCR (qPCR). In vitro transfection studies explored the impact of the miRNA on target protein expression. Expression of seven miRNA species, miR-30c-5p, miR-452-5p, miR-126-3p, miR-130b-3p, miR-148a-3p, miR-let-7a-5p and miR-let-7g-5p, was higher in the HUVECs of IGDM. Abundance of the catalytic subunit of AMP-activated protein kinase α1 (AMPKα1) was decreased in the HUVECs and BeWo cells (transformed trophoblast cell line) transfected with miR-130b and miR-148a mimics. AMPKα1 expression was also decreased in placental tissues of IGDM. The expression of several miRNAs were altered by in utero exposure to DM in infants of women whose dysglycaemia was very well controlled by current standards. Decreased expression of AMPKα1 as a result of increased levels of miR-130b and miR-148a may potentially explain the decrease in fat oxidation we reported in infants at 1 month of age and, if persistent, may predispose offspring to future metabolic disease.

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“…They found that miR-126 is the only miRNA whose expression is significantly reduced in susceptible individuals and T2DM patients compared with normal individuals, suggesting that plasma miR-126 may serve as a potential marker for the early prediction of susceptible individuals to T2DM [63]. If the miR-126 expression is found to be lower than 35 (relative quantification unit), the individual is likely to develop T2DM in the following two years [64]. Similarly, by comparing expression profiles of miRNAs in the plasma of patients with prediabetes and newly diagnosed T2DM, Yan et al demonstrated plasma miR-1249 , miR-320b , and miR-572 levels as potential biomarkers for early diagnosis of T2DM [65].…”

Section: Mirnas As Type 2 Diabetes (T2dm) Markers and Its Complicamentioning

confidence: 99%

Regulatory Roles of MicroRNAs in Diabetes

Feng

Xing

Xie

2016

IJMS

128

100

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MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have been recognized as significant regulators of gene expression through post-transcriptional mechanisms. To date, >2000 miRNAs have been identified in the human genome, and they orchestrate a variety of biological and pathological processes. Disruption of miRNA levels correlates with many diseases, including diabetes mellitus, a complex multifactorial metabolic disorder affecting >400 million people worldwide. miRNAs are involved in the pathogenesis of diabetes mellitus by affecting pancreatic β-cell functions, insulin resistance, or both. In this review, we summarize the investigations of the regulatory roles of important miRNAs in diabetes, as well as the potential of circulating miRNAs as diagnostic markers for diabetes mellitus.

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Circulating miR-126 is a potential biomarker to predict the onset of type 2 diabetes mellitus in susceptible individuals

Cited by 89 publications

References 26 publications

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina Pectoris

Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA

Regulatory Roles of MicroRNAs in Diabetes

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