Circulating miR-21-5p and miR-126-3p: diagnostic, prognostic value, and multivariate analysis in non-small-cell lung cancer

Soliman, Shimaa E.; Abdelaleem, A.; Alhanafy, Alshimaa Mahmoud; Ibrahem, Reda Abdel Latif; Elhaded, Asmaa S Abo; Assar, Mona Ali Mahmoud

doi:10.1007/s11033-021-06302-3

Cited by 13 publications

(10 citation statements)

References 27 publications

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“…Examination of miRNAs for specific fractions can significantly increase both the sensitivity and specificity of selected circulating miRNAs as noninvasive biomarkers [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Circulating Mirnamentioning

confidence: 99%

miRNAs in Cancer (Review of Literature)

Smolarz

Durczyński

Romanowicz

et al. 2022

IJMS

136

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MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell division, proliferation, differentiation, cell apoptosis and the formation of blood vessels. Altered expression of individual miRNAs has been shown in numerous cancers, which may indicate the oncogenic or suppressor potential of the molecules in question. This paper discusses the current knowledge about the possibility of using miRNA as a diagnostic marker and a potential target in modern anticancer therapies.

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Section: Circulating Mirnamentioning

confidence: 99%

miRNAs in Cancer (Review of Literature)

Smolarz

Durczyński

Romanowicz

et al. 2022

IJMS

136

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“…MiR-21 was found in various cancer types, including lung cancer [ 24 ], in which it acted as an oncomir [ 39 , 40 ]. It has been shown that the miR-21 was connected to the increased proliferation, invasion, and metastaticity of the tumour cells, as well as to their decreased apoptosis [ 24 , 39 , 41 ] and increased angiogenesis [ 40 , 41 ]. The miR-21 expression was found to be increased both in the plasma and in the tissues of the NSCLC patients when compared to the healthy control group [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…An increase in miR-126 expression has been linked to an increased overall survival from NSCLC [ 28 , 74 ]. MiR-126-3p is known to be a tumour suppressor [ 28 , 41 ] and a decrease in its expression has been noted in multiple tumour types [ 41 ]. It has been established that it could serve as a diagnostic factor due to a significant decrease in its expression in advanced-stage NSCLC compared to the early-stage NSCLC cases [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…MiR-126-3p is known to be a tumour suppressor [ 28 , 41 ] and a decrease in its expression has been noted in multiple tumour types [ 41 ]. It has been established that it could serve as a diagnostic factor due to a significant decrease in its expression in advanced-stage NSCLC compared to the early-stage NSCLC cases [ 41 ]. It was found to be strongly downregulated in the NSCLC [ 40 ] cell lines [ 27 , 75 , 76 ], tissues [ 27 , 74 , 75 , 76 ], body fluids [ 74 ], and serum-derived exosomes [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

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The Role of the Selected miRNAs as Diagnostic, Predictive and Prognostic Markers in Non-Small-Cell Lung Cancer

Szczyrek

Bitkowska

Jutrzenka

et al. 2022

JPM

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Lung cancer remains a leading cause of cancer-related deaths worldwide, overtaking colon, breast, and prostate cancer-related deaths. Due to the limited diagnostic possibilities, it is often diagnosed after it has reached an advanced stage. The delayed diagnosis significantly worsens the patient’s prognosis. In recent years, we have observed an increased interest in the use of microRNAs (miRNAs) as diagnostic, predictive, and prognostic markers in non-small-cell lung cancer (NSCLC). The abnormal expression levels of the miRNAs could be used to detect NSCLC in its early stages while it is still asymptomatic. This could drastically improve the clinical outcome. Furthermore, some miRNAs could serve as promising predictive and prognostic factors for NSCLC. Some of the currently available studies have shown a correlation between the miRNAs’ levels and the sensitivity of tumour cells to different treatment regimens. Analysing and modulating the miRNAs’ expression could be a way to predict and improve the treatment’s outcome.

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“…Lung cancer patients exhibit increased levels of miRNA-21-5p in their blood circulation [ 54 ]. MiRNA-21-5p inhibits the expression of SMAD7, which may enhance lung cancer cell proliferation, migration, and invasion [ 189 ].…”

Section: Tumor Enhancer Mirnamentioning

confidence: 99%

MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

et al. 2022

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Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.

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Circulating miR-21-5p and miR-126-3p: diagnostic, prognostic value, and multivariate analysis in non-small-cell lung cancer

Cited by 13 publications

References 27 publications

miRNAs in Cancer (Review of Literature)

miRNAs in Cancer (Review of Literature)

The Role of the Selected miRNAs as Diagnostic, Predictive and Prognostic Markers in Non-Small-Cell Lung Cancer

MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

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