Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes

Satake, Eiichiro; Pezzolesi, Marcus G.; Dom, Zaipul I. Md; Smiles, Adam M.; Niewczas, Monika A.; Królewski, Andrzej S.

doi:10.2337/db17-1207

Cited by 84 publications

(57 citation statements)

References 48 publications

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“…Satake et al measured plasma levels of 2083 known miRNAs and found that 54 miRNAs correlated with hyperglycemia in patients with T1DM. Furthermore, in this study, three (miR‐193a‐5p, miR‐200c‐3p, and miR‐7‐1‐3p) positively correlated with hemoglobin A1C (HbA1C) levels, whereas three miRNAs (miR‐1228‐3p, miR‐6793‐5p, and miR‐6799‐3p) negatively correlated with HbA1C levels …”

Section: Possible Associated Mechanism Between Mirnas and Dmmentioning

confidence: 49%

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

et al. 2019

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Diabetes mellitus (DM) has become the third major chronic non‐communicable disease affecting global public health, following cancer and cardiovascular and cerebrovascular diseases. Although previous studies have found a correlation between microRNA (miRNA) and the development of DM, thus far, most reviews have focused on the studies describing the changes in miRNA expression profiles and the mechanisms by which miRNAs‐induce DM. However, reviews summarizing the effect of miRNA single‐nucleotide polymorphisms on the developmental stages of DM and its complications are still needed. Studies on the variation of miRNAs will not only help to further understand the role that genetic factors play in DM, but will also have important implications for treatment and disease prognosis.

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Section: Possible Associated Mechanism Between Mirnas and Dmmentioning

confidence: 49%

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

et al. 2019

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“…The above study also corroborates well with our finding that miR-876-3p inhibition leads to decreased expression of pro-inflammatory cytokines in CI-induced IR adipocytes suggesting the role of latter in regulation of inflammatory micromilieu. miR876 has been found to be elevated in type 1 diabetes patient (Satake et al 2018). It has also been showed that miR876-5p is elevated in human trophoblast during gestational diabetes (Bari et al 2016).…”

Section: Discussionmentioning

confidence: 91%

miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin

Rajan

Panzade

Srivastava

et al. 2018

Journal of Endocrinology

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miRNA have been known to regulate diverse cellular and molecular functions. In the earlier study, we have reported that adipocytes differentiated from human mesenchymal stem cells (hMSC) on 72hr chronic insulin (CI) treatment exhibit insulin resistance (IR). Present study has further explored above model to investigate the role of early expressed miRNAs within human adipocytes to modulate differential adipokine expression as observed during IR. Our results highlight that miR-876-3p regulate glucose homeostasis and its dysregulation lead to IR. We found that miR-876-3p level is a critical determinant of adiponectin expression by virtue of its target within adiponectin 3'UTR. Regulatory effect of miR-876-3p impacts crosstalk between adiponectin and insulin signaling. Rosiglitazone treatment in CI induced IR adipocytes drastically reduced miR-876-3p expression and increased adiponectin level. In line with this, lentiviral mediated inhibition of miR-876-3p expression ameliorated CI and high fat diet (HFD) induced insulin resistance in adipocytes differentiated from hMSC and C57BL/6 mice. Our findings thus suggest that modulating miR-876-3p expression could provide novel opportunities for therapeutic intervention of obesity-associated metabolic syndrome.

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“…Ischemia/reperfusion-induced cardiac injury [76], cardiac cachexia, heart failure [77], atrial fibrillation [78], diffuse myocardial fibrosis in hypertrophic cardiomyopathy [30], coronary artery disease [79], pulmonary arterial hypertension [74], gestational diabetes mellitus [80], diabetes mellitus [13,23,81,82] [83] Hypertension [84], hypoxia-induced pulmonary hypertension [85], myocardial ischemia/reperfusion injury, acute myocardial infarction [84], ischemic dilated cardiomyopathy [66], obesity, regulation of insulin sensitivity [86], T1DM [87] hsa-miR-125b-5p 11q24.1 21q21.1 [88] Acute ischemic stroke [89], acute myocardial infarction [90,91], ischemic dilated cardiomyopathy [66], ascending aortic aneurysm [49], gestational diabetes mellitus [92], T1DM [93,94], T2DM [95] hsa-miR-126-3p 9q34.3 [96] Acute myocardial infarction [72], T2DM [53,97], T2DM with major cardiovascular events [53], gestational diabetes mellitus [98] hsa-miR-130b-3p 22q11.21 Hypertriglyceridemia [99,100], intracranial aneurysms [101], hyperacute cerebral infarction [102], T2DM [52,103,104], gestationa...…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus and Cardiovascular Risk Assessment in Mothers with a History of Gestational Diabetes Mellitus Based on Postpartal Expression Profile of MicroRNAs Associated with Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases

Hromadníková

Dvořáková

Krofta

2020

IJMS

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Mothers with a history of gestational diabetes mellitus (GDM) have an increased risk of developing diabetes in the future and a lifelong cardiovascular risk. Postpartal expression profile of cardiovascular/cerebrovascular disease associated microRNAs was assessed 3–11 years after the delivery in whole peripheral blood of young and middle-aged mothers with a prior exposure to GDM with the aim to identify a high-risk group of mothers at risk of later development of diabetes mellitus and cardiovascular/cerebrovascular diseases who would benefit from implementation of early primary prevention strategies and long-term follow-up. The hypothesis of the assessment of cardiovascular risk in women was based on the knowledge that a series of microRNAs play a role in the pathogenesis of diabetes mellitus and cardiovascular/cerebrovascular diseases. Abnormal expression profile of multiple microRNAs was found in women with a prior exposure to GDM (miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-100-5p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-221-3p, miR-342-3p, miR-499a-5p, and-miR-574-3p). Postpartal combined screening of miR-1-3p, miR-16-5p, miR-17-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-26a-5p, miR-29a-3p, miR-103a-3p, miR-133a-3p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p showed the highest accuracy for the identification of mothers with a prior exposure to GDM at a higher risk of later development of cardiovascular/cerebrovascular diseases (AUC 0.900, p < 0.001, sensitivity 77.48%, specificity 93.26%, cut off >0.611270413). It was able to identify 77.48% mothers with an increased cardiovascular risk at 10.0% FPR. Any of changes in epigenome (upregulation of miR-16-5p, miR-17-5p, miR-29a-3p, and miR-195-5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. In addition, novel epigenetic changes (upregulation of serious of microRNAs) appeared in a proportion of women that were exposed to GDM throughout the postpartal life. Likewise, a previous occurrence of either GH, PE, and/or FGR, as well as a previous occurrence of GDM, is associated with the upregulation of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-29a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p. On the other hand, upregulation of miR-16-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-103a-3p, miR-195-5p, miR-342-3p, and miR-574-3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. Screening of particular microRNAs may stratify a high-risk group of mothers with a history of GDM who might benefit from implementation of early primary prevention strategies.

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Circulating miRNA Profiles Associated With Hyperglycemia in Patients With Type 1 Diabetes

Cited by 84 publications

References 48 publications

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

MicroRNA single‐nucleotide polymorphisms and diabetes mellitus: A comprehensive review

miR-876-3p regulates glucose homeostasis and insulin sensitivity by targeting adiponectin

Diabetes Mellitus and Cardiovascular Risk Assessment in Mothers with a History of Gestational Diabetes Mellitus Based on Postpartal Expression Profile of MicroRNAs Associated with Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases

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