Circulating Natriuretic Peptide Concentrations in Patients With End-Stage Renal Disease: Role of Brain Natriuretic Peptide as a Biomarker for Ventricular Remodeling

Predictive Value of Brain Natriuretic Peptides in Patients on Peritoneal Dialysis

“…ANP and particularly BNP levels are linked independently to left ventricular mass (3-5,8 -16) and function (3,6 -17) and predict total and cardiovascular mortality (1,3,8,10,12,18,40). This The values for peritoneal ultrafiltration represent the lowest quintile of the time-dependent analysis.…”

“…Atrial natriuretic peptide (ANP) and particularly brain natriuretic peptide (BNP) levels are linked independently to left ventricular mass (3-5,8 -16) and function (3,6 -17) and predict total and cardiovascular mortality (1,3,8,10,12,18) as well as cardiac events (12,19). ANP and BNP decrease significantly during hemodialysis treatment but increase again during the interdialytic interval (1,2,4,6,7,14,17,20 -23).…”

A Cut off Value for Brain Natriuretic Peptide Indicating Volume Overload in Hemodialysis Patients

“…On the other hand, Osajima et al found no significant correlation between changes in plasma BNP concentration and reductions in body weight during HD [15]. Also, Cataliotti et al reported that BNP concentrations in HD patients without cardiovascular anomalies, hypertensive heart disease or ventricular dysfunction did not differ from those obtained from healthy subjects without cardiovascular or renal pathology [16].…”

Cardiovascular Disease in Patients With Chronic Renal Impairment: Role of Natriuretic Peptides

“…However, when BNP was entered in a multivariate model, the relative risk for mortality was lower than that predicted by C-reactive protein or left ventricular mass. 38 Similarly, Cataliotti and coworkers 39 reported that BNP was significantly higher in dialysis patients who died of cardiovascular causes compared with survivors and was significantly associated with greater risk of cardiovascular death. In addition, a recent study found that NTproBNP predicts mortality in patients with endstage renal disease receiving hemodialysis.…”

“…Early studies in patients receiving dialysis suggest that elevations of BNP are driven by the underlying presence of left ventricular hypertrophy. 39 In a small subgroup of patients who had end-stage renal disease and no underlying left ventricular hypertrophy, left ventricular dysfunction, previous myocardial infarction, coronary artery disease, stroke, or diabetes, levels of BNP were not significantly different from those in patients with preserved renal function. Similarly, in patients receiving hemodialysis without overt HF, BNP values were higher when left ventricular hypertrophy or left ventricular systolic dysfunction was present as measured by echocardiography.…”