Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Ezzeddini, Rana; Darabi, Masoud; Ghasemi, Babollah; Jabbari, Yalda; Abdollahi, Shahin; Rashtchizadeh, Nadereh; Gharahdaghi, Abasaad; Darabi, Maryam; Ansarin, Masoud; Shaaker, Maghsood; Samadi, Akbar; Karamravan, Jamal

doi:10.1016/j.ijporl.2011.12.026

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…The arachidonic acid is a precursor of prostaglandins and leukotrienes, and it is involved in inflammatory process characterized by increase by microvascular permeability and oedema formation, leukocyte recruitment into tissues, nociception, and release of inflammatory mediators which mimic a number of systemic and local inflammatory disorders in humans [1–5]. In addition, the excess levels of sPLA 2 s were associated with many physiopathological processes as cerebral illnesses, cardiovascular disorders, cancers, asthma, respiratory distress syndrome, and progression of tonsillitis [4–8]. On the other hand, the increased sPLA 2 activity is observed in some brain tumours, in chronic neurological disorders associated with neurodegenerative diseases, such as neural trauma, Alzheimer's, and Parkinson's diseases, and may serve as a marker of increases in permeability of the blood-cerebrospinal fluid barrier [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Carvalho

Santos

Xavier

et al. 2013

BioMed Research International

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Ophidian envenomation is an important health problem in Brazil and other South American countries. In folk medicine, especially in developing countries, several vegetal species are employed for the treatment of snakebites in communities that lack prompt access to serum therapy. However, the identification and characterization of the effects of several new plants or their isolated compounds, which are able to inhibit the activities of snake venom, are extremely important and such studies are imperative. Snake venom contains several organic and inorganic compounds; phospholipases A2 (PLA2s) are one of the principal toxic components of venom. PLA2s display a wide variety of pharmacological activities, such as neurotoxicity, myotoxicity, cardiotoxicity, anticoagulant, hemorrhagic, and edema-inducing effects. PLA2 inhibition is of pharmacological and therapeutic interests as these enzymes are involved in several inflammatory diseases. This review describes the results of several studies of plant extracts and their isolated active principles, when used against crude snake venoms or their toxic fractions. Isolated inhibitors, such as steroids, terpenoids, and phenolic compounds, are able to inhibit PLA2s from different snake venoms. The design of specific inhibitors of PLA2s might help in the development of new pharmaceutical drugs, more specific antivenom, or even as alternative approaches for treating snakebites.

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Section: Introductionmentioning

confidence: 99%

Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Carvalho

Santos

Xavier

et al. 2013

BioMed Research International

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“…Некоторые авторы полагают, что при рецидивирующем тонзиллите могут наблюдаться такие важные механизмы сосудистого ремоделирования, как системное воспаление, окислительный стресс, эндотелиальная дисфункция и гипоксия, которые могут способствовать ускоренному развитию атеросклероза [7]. У пациентов с ХТ подтверждено наличие в сыворотке крови повышенной активности фосфолипазы А2, которая играет важную роль в регуляции роста, дифференцировке тканей и воспалении, а также в развитии сердечно-сосудистых заболеваний и атеросклероза [8].…”

Section: результаты исследованияunclassified

Tonsil problem and its cardiovascular aspects at present stage

Eremin,

Simkhes,

Evsev’eva

et al. 2023

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A comparative assessment of the characteristics of myocardial and vascular damages as well as their occurrence in patients with decompensated chronic tonsillitis (CT) sent to the hospital for planned tonsillectomy were carried out. 179 people aged 18 to 25 years were examined. Two groups were formed: group 1: patients with decompensated СT (102 people) and group 2: control – that is, persons without СТ (77 people). We used 24-hour ECG monitoring (Holter) with a set of additional diagnostic options and EchoCG to determine various characteristics of myocardial activity. The arterial wall was assessed using indicators of vascular stiffness and assessment of blood pressure balance in the vascular territories. We used hardware-diagnostic complexes DMS Advanced Technologies (Russia) and RuSkan-70P (Russia). Myocardial damage was judged by exceeding the upper limit of the permissible norm for such indicators as the number of extrasystoles per hour, the maximum rate of increase in pressure in the aorta (dP/dTmax), and the size of the heart chambers; and damage to the vascular wall was judged by similar changes for the aortic pulse wave (PWVao), aortic reverse pulse wave augmentation index (AIx ao), and ankle-brachial index (ABI). The individual profile of the main cardiovascular risk factors was also assessed. Data processing was carried out using the Statistica 10.0 software package (StatSoft Inc., USA). The results indicated the presence of a negative effect of СТ not only on the myocardium with the development of some moderate changes but also on the vascular wall. The latter violations were recorded significantly more often. Vascular disorders were characterized by increased arterial stiffness and pressure imbalance within the framework of preclinical arterio- and atherosclerosis. It is necessary to develop targeted angioprotective measures with СТ and their inclusion in the comprehensive process of managing this category of patients, including in the preoperative period. Therefore, the management of such patients should be based on the principles of effective interdisciplinary cooperation.

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“…Under normal circumstances, as viruses and bacteria enter the body through the nose and mouth, they are filtered in the tonsils [9]. Within the tonsils, white blood cells of the immune system destroy the viruses or bacteria by producing inflammatory cytokines like Phospholipase A2 [10]which also lead to fever [9;11]. The infection may also be present in the throat and surrounding areas, causing inflammation of the pharynx [5].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Survey of Tonsillitis Caused by Streptococcuspyogenes Among Children in Awka Metropolis (A Case Study of Hospitals in Awka Community, Anambra State)

Okoye

Obiweluozor

et al. 2016

SSRN Journal

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Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Cited by 12 publications

References 25 publications

Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Tonsil problem and its cardiovascular aspects at present stage

Epidemiological Survey of Tonsillitis Caused by Streptococcuspyogenes Among Children in Awka Metropolis (A Case Study of Hospitals in Awka Community, Anambra State)

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Circulating phospholipase-A2 activity in obstructive sleep apnea and recurrent tonsillitis

Cited by 12 publications

References 25 publications

Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Snake Venom PLA2s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Tonsil problem and its cardiovascular aspects at present stage

Epidemiological Survey of Tonsillitis Caused by Streptococcuspyogenes Among Children in Awka Metropolis (A Case Study of Hospitals in Awka Community, Anambra State)

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Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules

Snake Venom PLA₂s Inhibitors Isolated from Brazilian Plants: Synthetic and Natural Molecules