Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva, Sonya; Iotova, Violeta; Yotov, Yoto; Bernasconi, Sergio; Street, Maria Elisabeth

doi:10.1530/eje-10-1124

Cited by 58 publications

(54 citation statements)

References 37 publications

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“…Therefore, the precise role of CRP in the development of CVD risk factors in humans remains unknown. In our study, CRP was positively correlated to fatness, similar to findings from several studies in youth [15,16,17,18,21,26,29]. Moreover, a significant correlation between CRP and the clustered z-score was only found in the group with S4SF values above the median.…”

Section: Discussionsupporting

confidence: 91%

“…In youth, markers of low-grade inflammation have been linked to all of the individual CVD risk factors [14,15,16,17,18,19], as well as to the MetS [20,21,22]. The presence of MetS in youth is typically determined using specific age and sex cut-points.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have found a positive correlation between the level of body fatness and the level of CRP [15,16,17,18,27], whereas a correlation between body fat and IL-6 and TNFα was found in some studies [17,18,28], but not in all [15,26]. Adiponectin has been found negatively correlated to the level of body fatness [17,21,28].…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

et al. 2012

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Aims: To evaluate the associations between inflammatory markers and clustering of cardiovascular disease (CVD) risk factors, and to examine how inflammatory markers and CVD risk are related to fatness and cardiorespiratory fitness (VO_2peak) in adolescents. Methods: Body mass and height, skinfolds and blood pressure of 413 adolescents (mean age 13.4 ± 0.3 years) were measured. Circulating fasting levels of glucose, insulin, lipids, adiponectin, C-reactive protein (CRP), tumor necrosis factor (TNF)α, soluble TNF receptor-1 (sTNFR1), interleukin (IL)-6 and IL-1 receptor antagonist (IL-1Ra) were measured. VO_2peak was measured in progressive tests to exhaustion. CVD risk was expressed as a clustered z-score, summing standardized values of individual risk factors. Results: The clustered z-score was negatively associated with adiponectin and positively associated with CRP, IL-6 and TNFα (all p values <0.05). The associations with adiponectin, CRP and IL-6 were stronger for the fattest adolescents. VO_2peak was negatively correlated with clustered z-score, adiponectin and IL-6 and positively related to systolic blood pressure. The sum of four skinfolds was inversely related to adiponectin and positively correlated to body mass index, systolic blood pressure, homeostasis model assessment, clustered z-score and CRP. Conclusion: In adolescents, CVD risk was associated with alternations in adiponectin, TNFα, CRP and IL-6, and related to both VO_2peak and fatness.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

et al. 2012

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“…This association has also been found in youth for obesity [9][10][11], central obesity [12,13], metabolic syndrome [14,15], atherosclerosis [16], and several other cardiovascular risk factors [10,13]. In addition, systemic inflammation in childhood and adolescence is known to continue into adulthood [17].…”

Section: Introductionmentioning

confidence: 79%

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

et al. 2017

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Background/objectives The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents.Subjects/methods The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models.Results DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95% CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95% CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95% CI:2.00-15.78, p trend = 0.002).Conclusions DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.

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“…Similarly to other reports (35,36), we did not find an association between TNF-α and IL-6 with the adiposity indicators. The production of these cytokines is guided mainly by visceral adipose tissue, which is still scarce in the age group of our study cohort, and it is possible that this inflammatory process is still not present at this time (37). Also, studies in rodents show that triglycerides and free fatty acids exert influence on TNF-α production and recombinant HDL administration has a reducing effect on the expression of this cytokine.…”

Section: Association Between Adiposity Indicators Metabolic Parametementioning

confidence: 90%

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Coutinho

Leite

Lopes

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents. Subjects and methods: The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin. Results: Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high-and low-density lipoprotein cholesterol did not correlate to the studied variables. Conclusion: BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population. Arch Endocrinol Metab. 2015;59(4):325-34

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Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Cited by 58 publications

References 37 publications

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Inflammatory Markers and Clustered Cardiovascular Disease Risk Factors in Danish Adolescents

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

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