Circulating Short-Chain Fatty Acids in Preterm Birth: A Pilot Case-Control Study

Nickodem, Colette; Menon, Ramkumar; McDonald, Thomas J.; Taylor, Brandie D.

doi:10.1007/s43032-019-00126-0

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…In addition, a higher expression of GPR43 was observed in fetal membranes of women delivering preterm with evidence of infection [ 48 , 49 ]. Another study showed a negative association between plasma SCFA and PTB [ 50 ]. These findings suggest that SCFAs play a protective role in PTB by regulating inflammatory processes through the suppression of GPR43.…”

Section: Discussionmentioning

confidence: 99%

Association between Preconception Dietary Fiber Intake and Preterm Birth: The Japan Environment and Children’s Study

Omoto,

Kyozuka,

Murata

et al. 2024

Nutrients

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Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. Therefore, this study aimed to determine whether preconception dietary fiber intake is associated with PTB. This was a prospective cohort Japan Environmental and Children’s Study (JECS). The study population comprised 85,116 singleton live-birth pregnancies from the JECS database delivered between 2011 and 2014. The participants were categorized into five groups based on their preconception dietary fiber intake quintiles (Q1 and Q5 were the lowest and highest groups, respectively). Multiple logistic regression analysis was performed to determine the association between preconception dietary fiber intake and PTB. Multiple logistic regression analysis revealed that the risk for PTB before 34 weeks was lower in the Q3, Q4, and Q5 groups than in the Q1 group (Q3: adjusted odds ratio [aOR] 0.78, 95% confidence interval [CI] 0.62–0.997; Q4: aOR 0.74, 95% CI 0.57–0.95; Q5: aOR 0.68, 95% CI 0.50–0.92). However, there was no significant difference between preconception dietary fiber intake and PTB before 37 weeks. In conclusion, higher preconception dietary fiber intake correlated with a reduced the risk for PTB before 34 weeks. Therefore, new recommendations on dietary fiber intake as part of preconception care should be considered.

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Section: Discussionmentioning

confidence: 99%

Association between Preconception Dietary Fiber Intake and Preterm Birth: The Japan Environment and Children’s Study

Omoto,

Kyozuka,

Murata

et al. 2024

Nutrients

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“…The dysbiosis of the maternal gut microbiomes may affect fetal birth outcomes through microbiome-generated metabolites. Nickodem et al [ 46 ] used plasma from 20 premature mothers and 30 healthy full-term mothers at the time of admission to labor and delivery to examine the maternal SFCAs to pregnancy outcome, founding that propionic acid in maternal plasma was negatively correlated with premature delivery. Although this is a pilot study, it provides an inspection to explore whether bacterial metabolites protect against inflammation pathways during pregnancy and reduce the incidence of PTB.…”

Section: Discussionmentioning

confidence: 99%

Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes

Yang

Ying

et al. 2023

BMC Microbiol

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Background Preterm birth is the leading cause of perinatal morbidity and mortality. Despite evidence shows that imbalances in the maternal microbiome associates to the risk of preterm birth, the mechanisms underlying the association between a perturbed microbiota and preterm birth remain poorly understood. Method Applying shotgun metagenomic analysis on 80 gut microbiotas of 43 mothers, we analyzed the taxonomic composition and metabolic function in gut microbial communities between preterm and term mothers. Results Gut microbiome of mothers delivering prematurely showed decreased alpha diversity and underwent significant reorganization, especially during pregnancy. SFCA-producing microbiomes, particularly species of Lachnospiraceae, Ruminococcaceae, and Eubacteriaceae, were significantly depleted in preterm mothers. Lachnospiraceae and its species were the main bacteria contributing to species’ differences and metabolic pathways. Conclusion Gut microbiome of mothers delivering prematurely has altered and demonstrates the reduction of Lachnospiraceae.

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“…Application of our method in a cohort of Chinese adults SCFA metabolism has been evaluated using rat and human serum, plasma, urine, and feces samples [10,14,19,20], mainly by using the GC-MS method. Hoving et al used penta uorobenzyl bromide as the derivatization reagent to quantify SCFAs in mouse feces, blood, and cecal samples [14].…”

Section: Stabilitymentioning

confidence: 99%

An UHPLC-QE-Orbitrap-MS Method for Accurate Quantification of Short-Chain Fatty Acids in Serum From an Older Chinese Population

Wang,

Feng,

Kong

et al. 2023

Chromatographia

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Short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, lactic acid, β-hydroxybutyric acid, and crotonic acid, play key biological roles and are also strongly associated with the maintenance of health and the development of age-related diseases. However, an accurate method for SCFA detection in human serum is lacking. Herein, we developed an UHPLC-QE-Orbitrap MS method based on 3nitrophenylhydrazine derivatization in negative electrospray ionization through parallel reaction monitoring mode for the simultaneous detection of 11 SCFAs in the serum, and the analysis was performed on an Agilent Proshell 120 EC-C 18 column (2.1 mm × 100 mm, 2.7 µm). Three pairs of isomers -isobutyric and butyric acid, isovaleric and valeric acid, and isocaproic and caproic acid-were completely separated in 20 min in a single run. Our method exhibited satisfactory linearity (r > 0.99) for all analytes, and both intrabatch and interbatch accuracies (73.74-127.9%) and precisions ( 21%) were acceptable. The extraction recoveries of all analytes were 90.80-111.7%, and the IS-normalized matrix effects were 74.43-116.9%. This optimized method was successfully applied to a cohort of 1021 older Chinese individuals. Our results may further the understanding of the metabolic phenotypes associated with SCFAs in other populations.

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Circulating Short-Chain Fatty Acids in Preterm Birth: A Pilot Case-Control Study

Cited by 8 publications

References 32 publications

Association between Preconception Dietary Fiber Intake and Preterm Birth: The Japan Environment and Children’s Study

Association between Preconception Dietary Fiber Intake and Preterm Birth: The Japan Environment and Children’s Study

Prematurely delivering mothers show reductions of lachnospiraceae in their gut microbiomes

An UHPLC-QE-Orbitrap-MS Method for Accurate Quantification of Short-Chain Fatty Acids in Serum From an Older Chinese Population

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