Circulating soluble gp130, soluble IL-6R, and IL-6 in patients undergoing cardiac surgery, with or without extracorporeal circulation

Corbi, Pierre; Rahmati, Mohammad; Delwail, Adriana; Potreau, Daniel; Menu, P; Wijdenes, John; Lecron, Jean‐Claude

doi:10.1016/s1010-7940(00)00388-2

Cited by 43 publications

(33 citation statements)

References 26 publications

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“…These evoke a marked inflammatory response, inducing the release of proinflammatory cytokines, such as IL-6. [31][32][33][34][35][36] We describe for the first time the effect of 3 common genetic polymorphisms found in the IL-6 gene promoter on basal and inflammatory IL-6 levels in patients undergoing elective CABG. The use of an in vivo acute inflammatory model, such as bypass surgery, allows more realistic assessment of genotype function than in vitro experimentation and may reflect changes that are clinically relevant.…”

Section: Discussionmentioning

confidence: 99%

“…[31][32][33][34][35][36] In the early phase, a severe acute inflammatory response occurs, resulting in a peak IL-6 response at the 6-hour time point. 32,34 -36 Evidently, a variety of different stimuli (such as sternal incision and general anesthesia) might be thought to play a role in the genesis of this response.…”

Section: Discussionmentioning

confidence: 99%

“…CABG is a well-characterized inflammatory stimulus that causes a substantial rise in circulating IL-6 levels that peak 6 hours after patients are placed on cardiopulmonary bypass (CPB). [31][32][33][34][35][36] Although a variety of different factors might act as potential stimuli to this inflammatory response, available evidence supports an important role for the process of CPB itself, 34 and accordingly, CABG provides a fairly uniform stimulus for IL-6 production. Therefore, the influence of IL-6 genotype on this more homogeneous acute inflammatory stimulus was the primary focus of the present study.…”

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confidence: 99%

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Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

Brull

Montgomery

Sanders

et al. 2001

ATVB

392

285

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Abstract-Interleukin-6 (IL-6) synthesized in response to diverse stimuli may play an important role in bridging the inflammatory and atherosclerotic processes. The acute-phase response after coronary artery bypass graft surgery (CABG) is associated with the induction and release of cytokines, such as IL-6. We have examined the effect of common polymorphisms in the IL-6 gene promoter (Ϫ174GϾC, Ϫ572GϾC, and Ϫ597GϾA) on IL-6 levels after elective CABG. DNA extracted from the peripheral blood of 127 patients was amplified by polymerase chain reaction. IL-6 genotypes were resolved by gel electrophoresis after restriction enzyme digestion. Serum IL-6 was measured before surgery and in serial samples at 6, 24, 48, and 72 hours after CABG. Genotype distribution was as expected for a population in Hardy-Weinberg equilibrium for all polymorphisms. Rare allele frequencies (Ϯ95% CIs) were similar to those reported previously: Ϫ597A 0.36 (0.30 to 0.42), Ϫ572C 0.07 (0.04 to 0.10), and Ϫ174C 0.37 (0.31 to 0.43). The Ϫ174GϾC and Ϫ597GϾA genotypes were in strong allelic association (⌬ϭ0.97, PϽ0.001). Baseline IL-6 levels did not significantly differ between patients with different genotypes for any polymorphism. However, 6 hours after CABG, peak IL-6 levels were significantly higher (Pϭ0.03) in carriers of the Ϫ572C allele than in those of the Ϫ572GG genotype (355Ϯ67 versus 216Ϯ13 pg/mL, respectively) and in those with genotype Ϫ174CC compared with Ϫ174G allele carriers (287Ϯ31 versus 227Ϯ15 pg/mL, respectively; Pϭ0.04). These effects remained statistically significant after adjusting for possible confounders, including age, sex, smoking, duration of cardiopulmonary bypass, aortic cross-clamp time, and total duration of surgery. These data demonstrate that IL-6 promoter polymorphisms influence peak IL-6 production after CABG, suggesting that these polymorphisms, which are functional in vitro, are also functional in vivo, suggesting a genetic influence on IL-6 levels after acute severe injury. (Arterioscler Thromb Vasc

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

Brull

Montgomery

Sanders

et al. 2001

ATVB

392

285

View full text Add to dashboard Cite

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“…Studies have shown a waterfall like release of inflammatory mediators whose peak times are between 4-12 hours 29,30 . This correlates well with the changes in the blood gases observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Metabolic changes and clinical outcomes in patients undergoing on and off pump coronary artery bypass surgery

Warang

Waradkar

Patwardhan

et al. 2007

Indian J Thorac Cardiovasc Surg

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“…Research has found that IL-6 level are significantly elevated one hour after initiation of CPB and peaks at six hours [9]. Surgical trauma, abnormal shear stress, ischemia, reperfusion, and hypothermia can activate the secretion of IL-6, which can remain elevated after surgery [10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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2017

Cent Asian J Med Sci

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Objectives: Cardiopulmonary bypass (CPB) using a heart-lung machine to perform open-heart surgery is known to be associated with numerous pathophysiologic changes in body systems. Soon after beginning extracorporeal circulation, an activation process of certain plasma protein systems occurs as blood contacts the foreign surfaces of the cardiopulmonary bypass circuit. During cardiac surgery with CPB, there is a systemic inflammatory reaction involving an enhanced release of inflammatory cytokines. In this study, we investigated the occurrence of systemic inflammatory response syndrome (SIRS) and the mechanisms that lead to the protraction of SIRS in patients who are operated under CPB. Methods: Blood samples from 27 patients (12 females and 15 males, aged 18-63 years) who underwent CPB were collected before and at several time points after surgery and analyzed for plasma levels of proinflammatory cytokines and white blood cells (WBC). Results: In patients with SIRS, the duration of CPB, interleukin-6 (IL-6) count, and WBC count after aortic declamping were significantly higher. The occurrence of SIRS was significantly correlated with the highest recorded level of IL-6 (OR 1.01, 95% CI 1.00-1.01, p<0.05) and the duration of CPB (r = 0.578, p<0.001). Conclusion: The study findings suggest that the duration of CPB and cytokinemia characterized by high IL-6 levels may play an important role in the development of the SIRS.

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Circulating soluble gp130, soluble IL-6R, and IL-6 in patients undergoing cardiac surgery, with or without extracorporeal circulation

Cited by 43 publications

References 26 publications

Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

Interleukin-6 Gene −174G>C and −572G>C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery

Metabolic changes and clinical outcomes in patients undergoing on and off pump coronary artery bypass surgery

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