Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria

Kasperska−Zając, Alicja; Damasiewicz-Bodzek, Aleksandra; Tyrpień-Golder, Krystyna; Zamłyński, Jacek; Grzanka, Alicja

doi:10.1007/s00011-016-0914-5

Cited by 7 publications

(9 citation statements)

References 16 publications

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“…Our study found no increase in plasma Hcy concentrations in patients with low vitamin B12 concentrations, which arguses against functional deficiency. Chronic and systemic low‐grade inflammation as determined by serum CRP is significantly increased in patients with more severe active CSU . As expected, CRP, which is a biomarker of inflammation associated with CSU, was generally elevated in our patients with CSU.…”

Section: Discussionsupporting

confidence: 83%

“…Chronic and systemic low-grade inflammation as determined by serum CRP is significantly increased in patients with more severe active CSU. 20 As expected, CRP, which is a biomarker of inflammation associated with CSU, was generally elevated in our patients with CSU. This observation may reflect vitamin B12 utilization in the presence of an underlying inflammatory process.…”

Section: Discussionsupporting

confidence: 83%

“…The urticaria activity score (UAS) was estimated over 4 days. On the day of blood sampling, it was graded as follows: mild (0-8), moderate (9)(10)(11)(12)(13)(14)(15)(16) or severe (17)(18)(19)(20)(21)(22)(23)(24). The study comprised 23 patients with mild and 19 patients with moderate to severe urticaria symptoms.…”

Section: Participantsmentioning

confidence: 99%

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Lower serum B12 vitamin concentrations are not accompanied by hyperhomocysteinaemia in chronic spontaneous urticaria

et al. 2016

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 83%

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Lower serum B12 vitamin concentrations are not accompanied by hyperhomocysteinaemia in chronic spontaneous urticaria

et al. 2016

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“…Thus, AGEs accumulate in extracellular spaces and interact with sRAGE [37]. Another possible explanation is the disruption of the AGEs-sRAGE axis that might induce a low synthesis of soluble receptors [18,36,38]. sRAGE is cleaved on cell surface through the action of matrix metalloproteinases.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between the Soluble Receptor for Advanced Glycation End Products and Oxidative Stress in Patients with Palmoplantar Warts

et al. 2019

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Background and objectives: Warts are the most common lesions caused by human papillomavirus (HPV). Recent research suggests that oxidative stress and inflammation are involved in the pathogenesis of HPV-related lesions. It has been shown that the soluble receptor for advanced glycation end products (sRAGE) may act as a protective factor against the deleterious effects of inflammation and oxidative stress, two interconnected processes. However, in HPV infection, the role of sRAGE, constitutively expressed in the skin, has not been investigated in previous studies. Materials and Methods: In order to analyze the role of sRAGE in warts, we investigated the link between sRAGE and the inflammatory response on one hand, and the relationship between sRAGE and the total oxidant/antioxidant status (TOS/TAS) on the other hand, in both patients with palmoplantar warts (n = 24) and healthy subjects as controls (n = 28). Results: Compared to the control group, our results showed that patients with warts had lower levels of sRAGE (1036.50 ± 207.60 pg/mL vs. 1215.32 ± 266.12 pg/mL, p < 0.05), higher serum levels of TOS (3.17 ± 0.27 vs. 2.93 ± 0.22 µmol H2O2 Eq/L, p < 0.01), lower serum levels of TAS (1.85 ± 0.12 vs. 2.03 ± 0.14 µmol Trolox Eq/L, p < 0.01) and minor variations of the inflammation parameters (high sensitivity-CRP, interleukin-6, fibrinogen, and erythrocyte sedimentation rate). Moreover, in patients with warts, sRAGE positively correlated with TAS (r = 0.43, p < 0.05), negatively correlated with TOS (r = −0.90, p < 0.01), and there was no significant correlation with inflammation parameters. There were no significant differences regarding the studied parameters between groups when we stratified the patients according to the number of the lesions and disease duration. Conclusions: Our results suggest that sRAGE acts as a negative regulator of oxidative stress and could represent a mediator involved in the development of warts. However, we consider that the level of sRAGE cannot be used as a biomarker for the severity of warts. To the best of our knowledge, this is the first study to demonstrate that sRAGE could be involved in HPV pathogenesis and represent a marker of oxidative stress in patients with warts.

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“…The multifactorial etiopathogenesis of CSU is not completely understood; however, the environmental challenges, such as distress and infection, are among the suspected causative factors. [1][2][3][4][5] Heat shock proteins (Hsp) are highly conserved cytoprotective and immunomodulatory molecules, which can be released from viable cells in response to several stressors, including mental and physiological stress, infection, inflammation, or other environmental challenges. [6][7][8] Hsp play a complex role in inflammation and function of the immune system.…”

Section: Introductionmentioning

confidence: 99%

Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria

Kasperska−Zając

Damasiewicz-Bodzek

Bieniek

et al. 2017

Int J Immunopathol Pharmacol

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Heat shock proteins (Hsp) play a complex role in cytoprotection, inflammation, and function of the immune system. They may be involved in pathogenesis of various diseases. Our aim was to determine circulating Hsp70 and anti-Hsp70 antibodies concentrations in patients with chronic spontaneous urticaria (CSU). Concentrations of Hsp70 in plasma and anti-Hsp70 antibodies in serum as well as serum C-reactive protein (CRP) were measured in CSU patients and in the controls. Plasma Hsp70 concentrations were significantly higher in CSU (all) and mild CSU patients as compared with the controls. Moderate-severe CSU patients tended to show higher Hsp70 concentration as compared with the controls, but not with mild activity of the disease. There were no significant differences in Hsp70 concentration between moderate-severe and mild CSU patients. Serum anti-Hsp70 antibodies concentrations were significantly higher in CSU (all) and mild CSU in comparison to the controls. Association was observed between anti-Hsp70 antibodies and increased CRP concentration; however, no correlation between anti-Hsp70 and Hsp70 concentrations was seen in the patients. It seems that up-regulation of Hsp70 in CSU may induce marked increase in anti-Hsp70 antibodies production, which are accompanied by parallel changes in CRP concentration. We suggest that Hsp may be released in CSU in response to stressful stimuli, such as inflammation.

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Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria

Cited by 7 publications

References 16 publications

Lower serum B12 vitamin concentrations are not accompanied by hyperhomocysteinaemia in chronic spontaneous urticaria

Lower serum B12 vitamin concentrations are not accompanied by hyperhomocysteinaemia in chronic spontaneous urticaria

The Relationship between the Soluble Receptor for Advanced Glycation End Products and Oxidative Stress in Patients with Palmoplantar Warts

Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria

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