Circulating Soluble SR-PSOX/CXCL16 as a Biomarker for Acute Coronary Syndrome -Comparison with High-Sensitivity C-Reactive Protein

Abstract

Aim: Diagnostic values of soluble SR-PSOX/CXCL16 (sSR-PSOX/CXCL16), a receptor for atherogenic oxidized LDL and a membrane-anchored chemokine for CXCR6-positive lymphocytes, for acute coronary syndrome (ACS) were evaluated. Methods: We examined 106 patients undergoing coronary angiography (CAG); 17 patients with ACS and 89 patients without ACS (non-ACS) including stable angina. Circulating sSR-SPOX/CXCL16 was measured in peripheral venous blood by sandwich ELISA. Results: Age, gender, prevalence of diabetes or hypertension, and serum lipid profiles were not significantly different between ACS and non-ACS. Presence or absence of risk factors, such as diabetes, smoking and hypertension, did not significantly affect circulating sSR-PSOX/CXCL16 levels. Circulating sSR-PSOX/CXCL16 levels were significantly lower in ACS than non-ACS (median: 3.05 versus 3.36 ng/mL, p 0.02). Lipid profiles, high-sensitivity C-reactive protein (hs-CRP), cardiac troponin T (TnT), and soluble LOX-1 (sLOX-1) showed no significant correlation with sSR-PSOX/ CXCL16. Receiver-operating characteristic (ROC) curves for ACS detection indicate higher sensitivity and specificity for sSR-PSOX/CXCL16 than hs-CRP. In the TnT-negative and sLOX-1-negative subpopulation, sSR-PSOX/CXCL16 showed similar sensitivity and specificity for ACS; however, hs-CRP showed less sensitivity and specificity for ACS when compared with the whole population. Conclusion: sSR-PSOX/CXCL16 is a biomarker for ACS, which would provide additional diagnostic information besides TnT and sLOX-1. J Atheroscler

Intense Yellow Culprit Plaque Coloration is Closely Associated with Troponin-T Elevation and Flow Complications Following Elective Coronary Stenting

“…Post-procedural elevation of cardiac biomarkers, such as troponin-T (TnT), has been recognized to be a relatively common phenomenon following successful percutaneous coronary interventions (PCIs) [1][2][3][4] . Previous studies have demonstrated that the elevation of TnT predicts long-term mortality [5][6][7] .…”

The Inflammatory Chemokine CXC Motif Ligand 16 Triggers Platelet Activation and Adhesion Via CXC Motif Receptor 6–Dependent Phosphatidylinositide 3-Kinase/Akt Signaling

“…27 Other recent studies described CXCL16 as a positively associated marker of inflammation and progression of coronary atherosclerosis, particularly ACS. 28,29 Furthermore, increased CXCL16 levels were demonstrated to be associated with long-term mortality in patients with ACS. 10 Although platelets are known to be the major players in the pathogenesis of atherothrombosis, 5 nothing is known about the influence of CXCL16 on platelet function.…”

Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy

“…It is known as a scavenger receptor that binds phosphatidylserine and oxidized lipoproteins (Mitsuoka et al, 2009). Garcia et al (2007) found that in glomerular nephritis, CXCL16 was expressed in glomerular endothelial cells under the stimulation of pro-inflammatory factors, while IL-1β promoted CXCL16 expression in mesangial cells.…”