Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia

Hsu, Shih Chang; Chang, Jer‐Hwa; Hsu, Yuan Pin; Bai, Kuan Jen; Huang, Shau Ku

doi:10.1371/journal.pone.0216963

Cited by 17 publications

(17 citation statements)

References 44 publications

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“…The serum S1P level decreased within other inflammatory conditions such as pancreatitis [44], or septic shock patients [45,46]. However, the opposite has also been reported, as the plasma S1P level increased in community-acquired pneumonia [47] or in human papillomavirus (HBV)-genotype D positive patients [48]. These data indicate that the plasma S1P level can be up- or down-regulated under various inflammatory conditions and that further studies investigating where plasma S1P comes from are needed.…”

Section: Discussionmentioning

confidence: 99%

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated

Bazarganipour

Hausmann

Oertel

et al. 2019

JCM

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The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon barrier is strongly influenced by sphingolipids. Sphingolipids impact cell–cell contacts and function as second messengers. We collected blood and colon tissue samples from UC patients and healthy controls and investigated the sphingolipids and other lipids by LC-MS/MS or LC-QTOFMS. The expression of enzymes of the sphingolipid pathway were determined by RT-PCR and immunohistochemistry. In inflamed colon tissue, the de novo-synthesis of sphingolipids is reduced, whereas lactosylceramides are increased. Reduction of dihydroceramides was due to posttranslational inhibition rather than altered serine palmitoyl transferase or ceramide synthase expression in inflamed colon tissue. Furthermore, in human plasma from UC-patients, several sphinglipids change significantly in comparison to healthy controls. Beside sphingolipids free fatty acids, lysophosphatidylcholines and triglycerides changed significantly in the blood of colitis patients dependent on the disease severity. Our data indicate that detraction of the sphingolipid de novo synthesis in colon tissue might be an important trigger for UC. Several lipids changed significantly in the blood, which might be used as biomarkers for disease control; however, diet-related variabilities need to be considered.

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Section: Discussionmentioning

confidence: 99%

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated

Bazarganipour

Hausmann

Oertel

et al. 2019

JCM

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“…Our initial findings suggest that plasma S1P is a potential biomarker for predicting prognosis in CAP. [9] In patients with CAP, the lung vascular barrier function is often compromised; therefore, higher S1P levels could be potentially beneficial in enhancing the endothelial functions. In CAP, although inflammation is important in host defense, exaggerated inflammation can damage the lungs, contributing to pulmonary dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…Then the patients will be divided into 2 groups based on the initial serum S1P level. According to our previous study, [9] low S1P producer is defined as a serum S1P concentration of less than 25 ng/mL. The effects of adjuvant corticosteroid therapy will be assessed in the low S1P producer and normal S1P producer group.…”

Section: Methodsmentioning

confidence: 99%

“…[8] Also, our recent observational study showed significantly elevated S1P levels in patients who were treated with methylprednisolone during hospitalization. [9] S1P is a bioactive sphingolipid with a documented regulatory role in immune defense and maintenance of endothelial barrier integrity. [10,11] Therefore, we believe that S1P plays an important role in the pathophysiology of pneumonia.…”

Section: Introductionmentioning

confidence: 99%

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Sphingosine-1-phosphate as an indicator for deciding the use of adjuvant corticosteroids therapy in community-acquired pneumonia (sphingosine-1-phosphate and pneumonia trial)

et al. 2019

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Introduction:Pneumonia is one of the leading causes of death worldwide, represents a potentially life-threatening condition. In recent studies, adjuvant corticosteroids therapy has been shown to improve outcome in severe community-acquired pneumonia (CAP); however, the treatment response to corticosteroids vary. It is important to select patients likely to benefit from the treatment. Currently, the optimal patient selection of corticosteroids treatment is not yet clearly defined.Methods:Sphingosine-1-phosphate and pneumonia (SOPN) trial is a double-blinded, randomized, placebo-controlled trial that will investigate if sphingosine-1-phosphate (S1P) can be an indicator for initiating adjuvant corticosteroids therapy in patients with severe CAP. Participants will be recruited from the emergency department and randomized to receive 20 mg of methylprednisolone twice daily or placebo for 5 days. The primary outcome will be “in-hospital mortality.” Secondary outcomes will include intensive care unit (ICU) admission, length of ICU stay, length of hospital stay, and clinical outcomes at Day 7 and Day 14.Conclusion:SOPN trial is the first randomized placebo-controlled trial to investigate whether S1P can be a predictive biomarker for adjuvant corticosteroids therapy in patients with severe CAP. The trial will add additional data for the appropriate use of adjuvant corticosteroids therapy in patients with severe CAP. Results from this clinical trial will provide foundational information supporting that if the S1P is appropriate for guiding the patient selection for corticosteroids adjuvant therapy.

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“…Furthermore, plasma levels of S1P were markedly elevated in CAP patients and were inversely correlated with disease severity and with predictive power for duration of hospital stay, ICU admission, and unfavorable outcome (87). In another study, (dihydro-) SM (d18:0 rsp.…”

Section: Sphingolipidomic In Infection and Sepsismentioning

confidence: 91%

Sphingolipidomics in Translational Sepsis Research–Biomedical Considerations and Perspectives

Claus

Graeler

2021

Front. Med.

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Scientific Background: Sphingolipids are a highly diverse group of lipids with respect to physicochemical properties controlling either structure, distribution, or function, all of them regulating cellular response in health and disease. Mass spectrometry, on the other hand, is an analytical technique characterizing ionized molecules or fragments thereof by mass-to-charge ratios, which has been prosperingly developed for rapid and reliable qualitative and quantitative identification of lipid species. Parallel to best performance of in-depth chromatographical separation of lipid classes, preconditions of precise quantitation of unique molecular species by preprocessing of biological samples have to be fulfilled. As a consequence, “lipid profiles” across model systems and human individuals, esp. complex (clinical) samples, have become eminent over the last couple of years due to sensitivity, specificity, and discriminatory capability. Therefore, it is significance to consider the entire experimental strategy from sample collection and preparation, data acquisition, analysis, and interpretation.Areas Covered: In this review, we outline considerations with clinical (i.e., human) samples with special emphasis on sample handling, specific physicochemical properties, target measurements, and resulting profiling of sphingolipids in biomedicine and translational research to maximize sensitivity and specificity as well as to provide robust and reproducible results. A brief commentary is also provided regarding new insights of “clinical sphingolipidomics” in translational sepsis research.Expert Opinion: The role of mass spectrometry of sphingolipids and related species (“sphingolipidomics”) to investigate cellular and compartment-specific response to stress, e.g., in generalized infection and sepsis, is on the rise and the ability to integrate multiple datasets from diverse classes of biomolecules by mass spectrometry measurements and metabolomics will be crucial to fostering our understanding of human health as well as response to disease and treatment.

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Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia

Cited by 17 publications

References 44 publications

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated

The Lipid Status in Patients with Ulcerative Colitis: Sphingolipids are Disease-Dependent Regulated

Sphingosine-1-phosphate as an indicator for deciding the use of adjuvant corticosteroids therapy in community-acquired pneumonia (sphingosine-1-phosphate and pneumonia trial)

Sphingolipidomics in Translational Sepsis Research–Biomedical Considerations and Perspectives

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