Circulating suPAR as a biomarker of disease severity in children with proteinuric glomerulonephritis

Sołtysiak, Jolanta; Zachwieja, Jacek; Benedyk, Anna; Lewandowska-Stachowiak, Maria; Nowicki, Michał; Ostalska‐Nowicka, Danuta

doi:10.23736/s0026-4946.16.04461-3

Cited by 10 publications

(11 citation statements)

References 34 publications

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“…Thus, 364 studies were initially included, among which 306 studies were excluded after reading the title and abstract. After reading the full text, another 29 studies were excluded; therefore, 29 studies were finally included 9–11 21–46. A flow chart of the study selection process is presented in figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…In total, there were 18 studies9 10 22–27 30 33–35 37 38 40–42 46 in which the concentrations of suPAR were compared between primary FSGS and the normal control group. The overall results showed that the level of suPAR in the primary FSGS group was significantly higher when compared with that in the normal control group (p<0.001; SMD: 2.56; 95% CI 1.85 to 3.28; I 2 =96.9%).…”

Section: Resultsmentioning

confidence: 99%

“…In a total of 19 studies,9 22 24–28 30 31 33–35 37 38 40 42 44–46 the concentrations of suPAR in primary FSGS and MCD were compared, and the results showed that the concentration of suPAR in primary FSGS was significantly higher compared with that in MCD (p<0.001; SMD: 1.72; 95% CI 1.17 to 2.28; I 2 =94.0%) (table 2).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies had a quality score between 5 and 7 and were at moderate risk. In eight cross-sectional studies,9 27 32 35 37 43 45 46 the AHRQ rating scale was used for scoring, and the scores were between 6 and 8, and were between medium and high quality. In studies22 23 30 31 34 40 43 involving the diagnostic part, the QUADS-2 scale was used for quality scoring.…”

Section: Resultsmentioning

confidence: 99%

“…In FSGS, the number of podocytes decreases, whereas in MCD it remains unchanged 51. Therefore, in some studies9 22 44 46 it was attempted to differentiate MCD from FSGS by suPAR in the early stage. Our results suggested that suPAR may be an early diagnostic factor for FSGS and MCD.…”

Section: Discussionmentioning

confidence: 99%

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Serum soluble urokinase type plasminogen activated receptor and focal segmental glomerulosclerosis: a systematic review and meta-analysis

et al. 2019

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ObjectivesSoluble urokinase plasminogen activated receptor (suPAR) is a biomarker that may predict the occurrence of focal segmental glomerulosclerosis (FSGS); however, there is still controversy about whether suPAR can predict FSGS. In this study, we performed a systematic evaluation and meta-analysis to prove whether suPAR can predict FSGS, and to detect a threshold concentration of suPAR that can be used to diagnose FSGS. In addition, a threshold concentration of suPAR for the diagnosis of FSGS was proposed.DesignSystematic review and meta-analysis.Data sourcesWe systematically searched PubMed, Embase, Cochrane Library, Web of Science and China Biology Medicine databases for studies published from the inception dates to 1 December 2018.Eligibility criteria(1) Data involving the suPAR level were from blood samples; (2) FSGS was diagnosed by biopsy; and (3) randomised controlled trials, cohort studies, case–control studies and cross-sectional studies.Data extraction and synthesisInitially, a total of 364 studies were searched, among which 29 studies were finally included. In addition, seven studies described the cut-off value of suPAR, which ranged from 2992.6 to 5500 pg/mL.ResultsThe results showed that the suPAR levels in the primary FSGS group were significantly higher when compared with that in the normal control group (p<0.001; standard mean difference (SMD): 2.56; 95% CI 1.85 to 3.28), and significant differences were observed in the secondary FSGS and in the normal control group (p<0.001; SMD: 1.68; 95% CI 1.37 to 1.98). A suPAR concentration of 3000 pg/mL may be the best threshold for the diagnosis of primary FSGS (sensitivity=0.72; specificity=0.88; area under the curve=0.85).ConclusionOur results suggested that suPAR might be a potential biomarker for predicting primary and secondary FSGS. In addition, our data showed that a suPAR concentration of 3000 pg/mL might be used as a threshold for the diagnosis of FSGS.Trial registration numberCRD42019120948.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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