Circulating T-helper 17 cells and associated cytokines in psoriasis

Abstract

Increased serum levels of circulating Th17 cells and related cytokines may contribute to the cutaneous pathology of psoriasis, as well as the inflammatory process that is a hallmark of psoriasis.

A phase I randomized controlled trial to evaluate safety and clinical effect of topically applied GSK2981278 ointment in a psoriasis plaque test

“…RORγt‐positive cells may be mobile within the affected areas and therefore may be scarce within the treated lesion, limiting the activity of drug. Cytokines/chemokines present in the area surrounding the treated field within a lesion may migrate and maintain the disease state. Inhibition of activity over the entire plaque may be required to produce detectable antipsoriatic effects.…”

Impaired Pulmonary Function in Patients with Psoriasis

“…IL-17 may induce expression of TNF-α, IL-1, and IL-8. IL-8 triggers neutrophil activation and migration of cells to the lung [6,11] . Psoriasis-related comorbidities including smoking, diabetes mellitus, hypertension, and metabolic syndrome may contribute to COPD development [12] .…”

“…Increases in the levels of C-reactive protein (a systemic inflammatory biomarker) and pro-inflammatory cytokines are associated with COPD disease activity. An association of IL-17, which is involved in the Th17 response to psoriasis [6] , with COPD has recently been shown. The sputum and bronchoalveolar lavage fluid of COPD patients exhibit increased expression of IL-17 and the other pro-inflammatory cytokines mentioned above [7][8][9] .…”

“…The chemokine receptor CXCR2 (an inflammatory marker), which plays a major role in neutrophil accumulation and angiogenesis at sites of inflammation, is associated with both psoriasis and COPD [10,11] . An aggravated inflammatory response may damage alveolar epithelial cells, triggering COPD [6][7][8][9][10][11] .…”

Phosphorylation of intracellular signalling molecules in peripheral blood cells from patients with psoriasis on originator or biosimilar infliximab

“…Patients have increased risk of cardiovascular disease and diabetes, indicating systemic inflammation. This is supported by higher numbers of circulating lymphocytes and increased gene expression of transcription factors and cytokines involved in differentiation of T helper (Th)1, Th17 and Th22 cells . Furthermore, patients with psoriasis display elevated levels of inflammatory cytokines in blood …”