“…The utility of pre-operative FNAC of thyroid nodules in CYP in differentiating benign and malignant disease has been evaluated via multiple studies including one meta-analysis ( Raab et al 1995 , Khurana et al 1999 , Hosler et al 2006 , Stevens et al 2009 , Altincik et al 2010 , Bargren et al 2010 , Hoperia et al 2010 , Kapila et al 2010 , Gutnick et al 2012 , Monaco et al 2012 , Redlich et al 2012 , Cole & Wu 2014 , Rossi et al 2014 , Buryk et al 2015 , Norlen et al 2015 , Partyka et al 2016 , Trahan et al 2016 ). In CYP, pre-operative FNAC has high sensitivity and specificity, as well as high-positive predictive and negative predictive values for the diagnosis of malignancy ( Stevens et al 2009 , Moudgil et al 2016 ), although there is variability in the interpretation of cytopathology findings between institutions ( Jia et al 2021 , Vuong et al 2021 , Cherella et al 2022 ).…”