Circulating tumor cells (CTCs) from metastatic breast cancer patients linked to decreased immune function and response to treatment

Green, Taryn L; Cruse, Julius M.; Lewis, Robert E.; Craft, Barbara S.

doi:10.1016/j.yexmp.2013.06.013

Cited by 35 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Futhermore, some studies have revealed the association of CTC number with immunity in cancer patients. Patients with higher positive CTC number than the baseline had decreased immune function in comparison to those lower than baseline or negative detection, especially for the patient with distant metastasis [44]. In other studies, higher level of CTC detected in breast cancer with bone metastases were correlated with lymphocytopenia [45, 46].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application

et al. 2016

View full text Add to dashboard Cite

IntroductionCirculating tumor cells (CTCs) play a crucial role in cancer metastasis. In this study, we introduced a novel isolation method by size of epithelial tumor cells (ISET) device with automatic isolation and staining procedure, named one-stop ISET (osISET) and validated its feasibility to capture CTCs from cancer patients. Moreover, we aim to investigate the correlation between clinicopathologic features and CTCs in colorectal cancer (CRC) in order to explore its clinical application.ResultsThe capture efficiency ranged from 80.3% to 88% with tumor cells spiked into medium while 67% to 78.3% with tumor cells spiked into healthy donors’ blood. In detection blood samples of 72 CRC patients, CTCs and clusters of circulating tumor cells (CTC-clusters) were detected with a positive rate of 52.8% (38/72) and 18.1% (13/72) respectively. Moreover, CTC positive rate was associated with factors of lymphatic or venous invasion, tumor depth, lymph node metastasis and TNM stage in CRC patients (p < 0.01). Lymphocyte count and neutrophil to lymphocyte ratio (NLR) were significantly different between CTC positive and negative groups (p < 0.01).Materials and MethodsThe capture efficiency of the device was tested by spiking cancer cells (MCF-7, A549, SW480, Hela) into medium or blood samples of healthy donors. Blood samples of 72 CRC patients were detected by osISET device. The clinicopathologic characteristics of 72 CRC patients were collected and the association with CTC positive rate or CTC count were analyzed.ConclusionsOur osISET device was feasible to capture and identify CTCs and CTC-clusters from cancer patients. In addition, our device holds a potential for application in cancer management.

show abstract

Section: Discussionmentioning

confidence: 99%

Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application

et al. 2016

View full text Add to dashboard Cite

show abstract

“…We thought that this situation was probably due to migratory and invasive abilities of mesenchymal CTCs. Also, disturbed immune system could be another reason for this phenomenon (34). During various risk factors, smoking strongly contributes to progression, local recurrence, metastasis, poor prognosis and risk of death of NPC (35).…”

Section: Discussionmentioning

confidence: 99%

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

Lan

Deng

et al. 2016

Japanese Journal of Clinical Oncology

View full text Add to dashboard Cite

Objective: Nasopharyngeal carcinoma is one of the leading malignancies with obscure etiology. Circulating tumor cells have been showed to intimately correlate with characteristics in different kinds of cancer. But links between circulating tumor cells and nasopharyngeal carcinoma were still lacking. Therefore, we explored circulating tumor cells' distribution in nasopharyngeal carcinoma and their possible associations with nasopharyngeal carcinoma. Methods: Firstly, we found that the positive ratio of circulating tumor cells is extremely high in four stages of nasopharyngeal carcinoma. Meanwhile, positive ratios of mesenchymal circulating tumor cells were higher in early stages of nasopharyngeal carcinoma. Apart from epithelial circulating tumor cells, total, hybrid and mesenchymal circulating tumor cells were correlated with nasopharyngeal carcinoma clinical stage. Results: Our results showed that hybrid and mesenchymal circulating tumor cells were associated with nasopharyngeal carcinoma metastasis (both distant and lymph node) and smoking. Meanwhile, hybrid circulating tumor cells expressed the highest Epstein-Barr virus proteins and deoxyribonucleic acid in three types of circulating tumor cells. Moreover, we found that Epstein-Barr virus proteins viral-caspid antigen-immunoglobulin A (VCA/IgA) and early antigen-immunoglobulin A (EA/IgA), but not Epstein-Barr virus-deoxyribonucleic acid, had a closed association with nasopharyngeal carcinoma metastasis. However, Epstein-Barr virus hallmarks failed to associate with other nasopharyngeal carcinoma characteristics. Furthermore, we confirmed that matrix metalloproteinase 9 existed in circulating tumor cells and expressed most in mesenchymal circulating tumor cells. In addition, matrix metalloproteinase 9-expressed extent in hybrid circulating tumor cells is somewhat different from epithelial and mesenchymal circulating tumor cells in matrix metalloproteinase 9-positive circulating tumor cells. Nevertheless, matrix metalloproteinase 9 had no relationship with other nasopharyngeal carcinoma characteristics. Finally, our results showed that circulating tumor cells were decreased in patients after therapies. carcinoma metastasis. Of note, decreased circulating tumor cells indicated a favorable curative effect in nasopharyngeal carcinoma patients.

show abstract

“…Although there is a lack of strong evidence regarding the potential of CTCs to resist immune clearance, CTCs were previously found to be associated with impaired immune function in patients (28,29). In addition, certain single CTCs can survive for a considerable time in the circulatory system due to their probable potential of passing through capillaries and proliferating to form CTC clusters.…”

Section: Hypothesismentioning

confidence: 99%

A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Hong

Li²,

Zhang

2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Metastasis is the major cause of mortality in patients with malignancies; however, the mechanisms of tumor cell dissemination and metastasis formation are obscure. Circulating tumor cells (CTCs) are believed to be a critical step for distant metastasis and are associated with a poor patient prognosis. The precise processes of metastasis formation from CTCs are vague. In the present study, we hypothesize that two CTC cluster-based mechanisms of tumor cell inoculation in ectopic organs may be viable: i) Formation of a micro-cancer embolus due to interception of CTC clusters by small vessels; and ii) formation of micrometastasis in an extravasation-dependent or -independent manner. Pathological evidence of micro-cancer emboli is critical for the verifications of this hypothesis. If proved true, this hypothesis will provide a novel perspective for cancer metastasis and has valuable clinical implications.

show abstract

Circulating tumor cells (CTCs) from metastatic breast cancer patients linked to decreased immune function and response to treatment

Cited by 35 publications

References 37 publications

Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application

Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application

Distribution and clinical significance of circulating tumor cells in nasopharyngeal carcinoma

A circulating tumor cell cluster-based model for tumor metastasis (Hypothesis)

Contact Info

Product

Resources

About