2012
DOI: 10.1093/annonc/mds138
|View full text |Cite
|
Sign up to set email alerts
|

Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

10
181
2
2

Year Published

2013
2013
2024
2024

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 195 publications
(195 citation statements)
references
References 28 publications
10
181
2
2
Order By: Relevance
“…For example, in SCLC the total numbers of CTCs were significantly decreased following a single dose of chemotherapy (166,167). Similar results were observed in patients with NSCLC (5,(168)(169)(170).…”
Section: Treatment Response and Mechanisms Of Resistancesupporting
confidence: 69%
“…For example, in SCLC the total numbers of CTCs were significantly decreased following a single dose of chemotherapy (166,167). Similar results were observed in patients with NSCLC (5,(168)(169)(170).…”
Section: Treatment Response and Mechanisms Of Resistancesupporting
confidence: 69%
“…A reduction of CTC count exceeding 89% in response to chemotherapy was associated with a lower risk of death (HR =0.24; 95% CI, 0.09-0.61). Similarly, lower numbers of CTCs were observed for 21 patients with LD-SCLC (median =6; range, 0-220) compared with 38 patients with ED-SCLC (median =63; range, 0-14,040) and the absence of CTCs in 27% of patients was correlated with prolonged survival (HR =3.4; P≀0.001) (62).…”
Section: Sclc and Ctcsmentioning
confidence: 79%
“…Indeed, a O33% higher number of CTC, measured after 3-5 weeks of treatment, was associated with poorer PFS and OS (respective HR, 23.1 and 18.9) compared with no increase (Khan et al 2012). Whether serial CTC determinations could be relevant for NET follow-up and a potential surrogate of therapeutic response requires further investigation in specific clinical trials, as shown for other malignancies (Matsusaka et al 2010, Danila et al 2011, Hiltermann et al 2012, Boutrus et al 2013. However, the main limitations of using CTC in routine practice are the limited availability and non-standardization of their measurement technique.…”
Section: Biological Markers Tumor Progression and Therapeutic Respomentioning
confidence: 99%