Circulating tumor cells: Screening and monitoring of oral cancers

Chowdhury, R; Bhatia, Sudershan K.; Singh, Gagandeep; Nasreen, Saba; D, De Moulin

doi:10.1016/j.jormas.2018.06.008

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…Various techniques have been used clinically to detect tumor information, including CTC and ctDNA detection. [25,26] However, the price of these tests is so high that many patients cannot afford them, especially in developing countries. In areas with poor economic and health conditions, the morbidity associated with hepatolithiasis and ICC is higher than in developed countries.…”

Section: Discussionmentioning

confidence: 99%

A novel prognostic model for diagnosing atypical bile duct hyperplasia in patients with intrahepatic lithiasis

Lü

Yang

et al. 2019

Medicine

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Section: Discussionmentioning

confidence: 99%

A novel prognostic model for diagnosing atypical bile duct hyperplasia in patients with intrahepatic lithiasis

Lü

Yang

et al. 2019

Medicine

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“…When lump-specific antigens were investigated, recent research revealed that circulating tumor DNA (ctDNA) was a better predictive marker than CTC. In recent studies, circulating cell-free DNA has been proven to be so sensitive in picturizing the entire malignant condition that it can be reliably used as a source of DNA to help us detect the malignancy, substituting tumor tissue in established diagnostic procedures [ 16 ]. Following studies on the dissemination of cancer cells post-surgery and the increase of tumor cells as a result of surgical treatments for OSCC patients, only a few of these studies have looked into the influence of metastasis and survival in this regard.…”

Section: Reviewmentioning

confidence: 99%

Circulating Tumor Cells in Oral Cancer

Sharma,

Gawande,

Reche

et al. 2024

Cureus

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Till now, oral squamous cell carcinoma (OSCC) is graded as well-differentiated, moderately-differentiated, poorly-differentiated, and undifferentiated. However, this grading does not have a prediction of the prognosis of the patient. Also, prognosis impacts lymph node metastases, surgical margins, and vascular invasions (neural invasion, muscular invasion, salivary gland invasion). The prognosis of lymph node metastases is significant, which affects the survival of the patients which is 50%. So, a dependable blood marker is needed for prognosis in OSCC patients with loco-regional and distant recurrence. Some factors can be assisted only after surgery and invasive techniques to check the prognosis of the disease. Despite the ease of examining the oral cavity, there is no practical approach for non-invasive screening and detecting cancer. As it is abrupt to use such invasive procedures from time to time, there is a need for nonsurgical and reliable techniques to assess the progression of tumors. Also, frozen sections are helpful during the intraoperative procedure to evaluate the lymph node metastases. An increase in the number of tumor cells through blood is a significant event in disease metastases toward the peripheral blood. Oral health impact assessment instruments could aid in determining the quality of life, and their usage in the initial stages of oral carcinoma could help physicians choose the best treatment option for enhancing the quality of life.

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