Circulating tumor DNA in head and neck cancer: Early successes and future promise

Soo, Joanne; Jin, Michael C.; Beadle, Beth M.; Holsinger, Christopher; Finegersh, Andrey

doi:10.1002/cncr.34189

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…In clinical setting, the use of ctHPVDNA during the diagnostic workup could improve accuracy, reduce costs and shorten diagnostic time 61 . In a prospective study, Siravegna et al 38 compared standard clinical approach versus imaging/physical exam findings associated to ctHPVDNA liquid biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…35 In clinical setting, the use of ctHPVDNA during the diagnostic workup could improve accuracy, reduce costs and shorten diagnostic time. 61 In a prospective study, Siravegna et al 38 compared standard clinical approach versus imaging/physical exam findings associated to ctHPVDNA liquid biopsy. Although in limited number of patients (70 cases and 70 controls) the study showed that the diagnostic accuracy of this noninvasive approach was significantly better than standard of care (Youden index 0.937 vs. 0.707, P 1/4 0.0006), costs were 36%-38% lower, and the median diagnostic interval was 26 days shorter.…”

Section: Qualitative Assessmentmentioning

confidence: 99%

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It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Paolini,

Campo,

Iocca

et al. 2023

Head & Neck

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The possibility of detecting circulating tumor HPV DNA (ctHPVDNA) in plasma in patients with oropharyngeal cancer has been demonstrated in several reports. However, these data are from small cohorts and available tests for detection of ctHPVDNA are not fully validated. The aim is to evaluate sensitivity, specificity, and accuracy of ctHPVDNA by ddPCR to define its efficacy in the clinical setting for the diagnosis of HPV + OPSCC. A comprehensive search of three different databases: MEDLINE, Embase, and Cochrane Library databases. A total of 998 patients were evaluated from the 13 studies. OPSSC p16+ were 729, while controls p16− were 269. The meta‐analytic study estimated the diagnostic performance of ctHPVDNA as follows: pooled sensitivity and specificity of 0.90 (95% CI: 0.82–0.94) and 0.94 (95% CI: 0.85–0.98), respectively; positive and negative likelihood ratios of 12.6 (95% CI: 4.9–32.1) and 0.05 (95% CI: 0.02–0.13), respectively. ddPCR for ctHPVDNA has good accuracy, sensitivity, and specificity for diagnosis of HPV + OPSCC. ctHPVDNA kinetic represents a great reliable opportunity to improve diagnostic and therapeutic management of cancer patients and could open new perspectives for understanding tumor biology.

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Section: Discussionmentioning

confidence: 99%

Section: Qualitative Assessmentmentioning

confidence: 99%

It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Paolini,

Campo,

Iocca

et al. 2023

Head & Neck

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“…In the future, an alternative to post-treatment assessment for patients with HPV-DNApositive cancer may be measuring circulating tumour HPV-DNA (ctHPVDNA) [26][27][28]. Possibly combining FDG PET-CT and ctHPVDNA may be even more useful.…”

Section: Discussionmentioning

confidence: 99%

Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16

Landin

Näsman

Jara

et al. 2022

Viruses

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Human-papillomavirus (HPV)-positive tonsillar and base of tongue carcinomas (TSCC/BOTSCC) are rising in incidence and treatments with radiotherapy, chemoradiotherapy (RT/CRT), and neck dissections (NDs) have several side effects. Therefore, an improved selection of patients needing salvage NDs would be beneficial. We examined the prevalence and localisations of viable tumour cells in neck lymph nodes in patients post-RT/CRT, identified by fluorodeoxyglucose positron-emission tomography with computer-tomography (FDG PET-CT), with a focus on HPV-associated tumours. Patients with 217 TSCC/BOTSCC with tumours assessed for HPV-DNA and p16INK4a undergoing FDG PET-CT 12 weeks after treatment and/or an ND were included. The FDG PET-CT data were compared with the findings in the pathology report after the ND. In total, 36/217 (17%) patients were selected for an ND due to positive findings in post-treatment FDG PET-CT. Of these, 35/36 were HPV-associated, 10/36 (28%) had viable tumour cells in the pathology reports of the neck specimen, and 8/10 (80%) were consistent with the FDG PET-CT findings, while 2/36 (5%) were missed by FDG PET-CT. We conclude that FDG PET-CT 12 weeks after RT/CRT is useful, but not completely reliable for finding all the metastases of HPV-associated TSCC/BOTSCC. Nonetheless, our data indicate that an ND could be more selectively guided by FDG PET-CT.

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Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis

Ammirabile,

Mastroleo,

Marvaso

et al. 2024

Critical Reviews in Oncology/Hematology

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Circulating tumor DNA in head and neck cancer: Early successes and future promise

Abstract: The genetic components (DNA) of human papillomavirus-related throat cancer (in the oropharynx) might be measured after surgery to help to predict whether treatment has been successful.

Cited by 3 publications

References 25 publications

It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: Systematic review and meta‐analysis

Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16

Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis

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