2004
DOI: 10.1038/sj.eye.6701574
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Circulation and axonal transport in the optic nerve

Abstract: Retinal ganglion cells are the output cells of the retina whose axons are under considerable metabolic stress in both health and disease states. They are highly polarised to ensure that mitochondria and enzymes involved in the generation of ATP are strategically concentrated to meet the local energy demands of the cell. In passing from the eye to the brain, axons are protected and supported by glial tissues and the blood supply of the optic nerve head is regulated to maintain the supply of oxygen and nutrients… Show more

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Cited by 87 publications
(62 citation statements)
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“…Distal sites within the optic pathway of the DBA/2 also demonstrate axonal dystrophies (Fig. S3); these are indicative of local blockade of cytoskeletal, metabolic, or synaptic components (41). In acute glaucoma models, RGC targets in the brain demonstrate atrophy associated with loss of recipient neurons (42).…”
Section: Discussionmentioning
confidence: 99%
“…Distal sites within the optic pathway of the DBA/2 also demonstrate axonal dystrophies (Fig. S3); these are indicative of local blockade of cytoskeletal, metabolic, or synaptic components (41). In acute glaucoma models, RGC targets in the brain demonstrate atrophy associated with loss of recipient neurons (42).…”
Section: Discussionmentioning
confidence: 99%
“…The high-energy demand of particularly the photoreceptors, which respond to the light and the retinal ganglion cells, the axons of which constitute the optic nerve that transmits the visual output to the brain, is fulfilled mainly by the oxygen-dependent generation of adenosine triphosphate (ATP) [3,4]. This in turn necessitates a constant blood flow through the retinal vasculature and choroid, with the former providing oxygen and nutrients to the ganglion cells and the inner retinal neurons and the latter supporting the photoreceptors in the outer retina [2].…”
Section: Introductionmentioning
confidence: 99%
“…Im Gegensatz zur A. ciliaris posterior verfügen diese Gefäße über keine Autoregulation [51]. Daher ist der Blutfluss im hinteren Teil des Sehnervs auch deutlich geringer als im vorderen Abschnitt [29]. Zudem gibt es Variationen in der Ausprägung der Anastomosenbildung zwischen beiden Systemen [17]; insbesondere, wenn keinerlei Verbindungen bestehen, liegt eine "EndarterienSituation" vor [6].…”
Section: Introductionunclassified