Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Pandya, Shivani R.; Singh, Harjeet; Desimone, Martin F.; Singh, Jagpreet; George, Noble; Jasani, Srushti

doi:10.1039/d3ma00629h

Mater. Adv.

2024

DOI: 10.1039/d3ma00629h

|View full text |Cite

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Shivani R. Pandya,

Harjeet Singh,

Martin F. Desimone

et al.

Abstract: Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 11 publications

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Xu,

Yu,

Jia

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

Abiotic stress tends to induce oxidative damage to enzymes and organelles that in turns hampers the phosphorylation process and decreases the adenosine triphosphate (ATP) productivity. Artificial assemblies can alleviate abiotic stress and simultaneously provide nutrients to diminish the oxidative damage. Here, we have integrated natural acid phosphatase (ACP) and ATP synthase with plasmonic Au clusters in a biomimetic microreactor. ACP immobilized on the Au clusters is harnessed to generate proton influx to drive ATP synthase and concurrently supply phosphate to improve phosphorus availability to combat phosphorus‐deficiency stress. In tandem with the reactive oxygen species (ROS) scavenging and the photothermal functionality of Au clusters, such an assembled microreactor exhibits an improved abiotic stress tolerance and achieves plasmon‐accelerated ATP synthesis. This innovative approach offers an effective route to enhance the stress resistance of ATP synthase‐based energy‐generating systems, opening an exciting potential of these systems for biomimicking applications.

show abstract

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Xu,

Yu,

Jia

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Xu,

Yu,

Jia

et al. 2024

Angew Chem Int Ed

View full text Add to dashboard Cite

show abstract

Subcellular targeting strategies for protein and peptide delivery

Su,

Rong,

et al. 2024

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Circumventing challenges in mitochondrial targeting for cancer treatment: leveraging nanoplatforms for effective solutions

Abstract: Cancer is a highly complex disease that affects lives and causes millions of deaths worldwide.

Cited by 11 publications

References 221 publications

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Artificial Mitochondria Nanoarchitectonics via a Supramolecular Assembled Microreactor Covered by ATP Synthase

Subcellular targeting strategies for protein and peptide delivery

Contact Info

Product

Resources

About