Cisplatin-associated cortical blindness

lnterleukin‐2 and Cisplatinum Therapy Toxicity Mimicking Basilar Artery Disease

“…Several reports have emphasized, as with the present experience, that steroid treatment was associated with prompt improvement [3,5,7,9,10]. The long-term efficacy of treating the acute episodes with steroids is unknown.…”

Cis-platinum chemotherapy for ocular basal cell carcinoma.

“…27 There are a number of reports describing the ocular side effects of cis-platinum or chemotherapeutic regimens that contain cis-platinum: cortical blindness, optic disc swelling, retrobulbar neuritis, homonomous hemianopsia, retinal pigmentary changes, abnormalities of electroretinogram and visually evoked potentials and encephalopathy. [28][29][30][31] While the preferred method of treatment of basal cell carcinoma is surgical excision, there are circumstances when that is impossible. Occasionally a patient refuses to have surgery.…”

Retinal toxicity associated with cisplatin and etoposide in pediatric patients

“…No measurements of renal function in the affected patients before or at the onset of symptoms were provided. Berman and Mann [9], Pippitt REFERENCES et al [10], and Diamond and colleagues [11] described…”

“…Further studies to better define the mechanism of cisplatin-induced visual are more frequently reported in adults [9][10][11][12][13][14], possibly because abnormal renal function is more common among toxicity, as well as the pharmacokinetics of cisplatin in children, may provide methods of preventing this disadult patients. Wilding et al [14] substantiated the relationship of HDP to retinal toxicity by the prospective tressing complication of therapy.…”

“…Although less common, num (HDP) (40 mg/m 2 /day) and etoposide (100 mg/m 2 / visual toxicity related to the use of cisplatin is well de-day) both for 5 days with bleomycin (50 mg/m 2 /day) on scribed in adults [9][10][11][12][13][14], but not in pediatric patients [15]. day 1.…”