Citicoline loaded nanoemulsion enriched with D-alpha-Tocopherol acetate and protein: Formulation and in-silico study

Roy, Harekrishna; Srungarapati, Swati; Gade, Nirmala Jyothi; Gummadi, Asha; Karunasree, Butty Kejiya Marry; Dakkumalla, Monika; Maddiboyina, Balaji

doi:10.1016/j.jddst.2023.104340

Cited by 9 publications

(3 citation statements)

References 60 publications

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“…The drug solution drained from the Franz cell at regular intervals, and its concentration in solution can be measured using High Performance Liquid Chromatography. From the drug analysis, the penetration of the drug can be evaluated (Maddiboyina et al, 2023; Roy et al, 2023). Every part of the body has its own pH value.…”

Section: Transdermal Systemmentioning

confidence: 99%

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

Nayak¹,

Mohanty²,

Mishra³

et al. 2023

Chem Biol Drug Des

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The skin is a major route of drug administration. Despite the high surface area of the skin, drug delivery via the skin route is problematic due to its physiological obstacles. The formulation scientist has developed a vesicular system to enhance the skin's absorption of bioactive substances. Among numerous vesicular systems, concept of transethosomes (TEs) introduced in 2012 are being tested for drug delivery to the dermis. When transferosomes and ethosomes interact, TEs are produced. It consists of water, ethanol, phospholipids, and an edge activator. Ethanol and the edge activator increase the absorption of medication through the skin. In the presence of ethanol and an edge activator, skin permeability can increase. The advantages of TEs include increased patient compliance, bypassing first‐pass metabolism, including non‐toxic raw components, being a noninvasive method of drug delivery, being more stable, biocompatible, biodegradable, and administered in semisolid form. TEs can be produced through the use of hot, cold, mechanical dispersion, and conventional techniques. The morphology, shape, size, zeta potential, drug loading efficiency, vesicle yield, biophysical interactions, and stability of TEs define them. Recent studies reported successful transdermal distribution of antifungal, antiviral, anti‐inflammatory, and cardiovascular bioactive while using ethosomes with significant deeper penetration in skin. The review extensively discussed various claims on TEs developed by researchers, patents, and marketed ethosomes. However, till today no patens being granted on TEs. There are still lingering difficulties related to ethanol‐based TEs that require substantial research to fix.

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Section: Transdermal Systemmentioning

confidence: 99%

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

Nayak¹,

Mohanty²,

Mishra³

et al. 2023

Chem Biol Drug Des

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“…Unfortunately, the full realization of combination therapy through systemic delivery of free drugs is hampered by challenges such as poor solubility, variable stability, unsynchronized pharmacokinetics, and uneven tumor accumulation of combination drugs. The application of nanoparticles for simultaneous drug delivery represents a promising solution to overcome these obstacles 20 – 22 . This approach aims to overcome the drug efflux associated with extrinsic resistance, increase the circulation half-life in the bloodstream, facilitate drug targeting through surface functionalization and enable spatio-temporally controlled release of the drug cargo 23 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Kenawy,

Abd El.Hay,

Saad

et al. 2024

Sci Rep

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Poly l(+) lactic acid (PLLA) has become crucial in the biomedical industry for various uses. The direct polycondensation method was used to prepare Poly l(+) Lactic Acid (PLLA). Different catalysts, including metal oxides and metal halides, were used to test the polymerization technique. The effect of the amount of catalysts and the type of coupling agent were investigated. The effect of reaction time and polymerization solvents was also studied. PLLA was loaded with isosorbide dinitrate utilizing the solvent evaporation process. The synthesized polymer-drug system was evaluated by different means such as FT-IR, TGA, DSC, XRD, entrapment efficiency (E.E), drug loading (D.L), particle size analysis, and zeta potential determination. Studies on in-vitro release using UV light at 227 nm at various pH levels were conducted, and the kinetics of release and cytotoxicity using the sulforhodamine B (SRB) assay on human skin fibroblast cells were examined.

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“…Gliflozins, also known as inhibitors of sodium-glucose co-transporter-2 (SGLT2), are one of several types of anti-diabetic medications (ADAs) having a proven track record of curing type-2 diabetes (T 2 D) 1 , 26 . However, due to its unique properties, the mechanism of action which is not dependent on the insulin (promote glycos-uria), which, is most probably used to lower the glucose present in plasma, also improves various kinds of metabolisms and hemodynamic abnormalities that are CVD risk causing agents, gliflozins possess distinct properties from other ADAs 27 , 28 . For the administration of type-2 diabetes (T 2 D) in adults, empagliflozin.…”

Section: Introductionmentioning

confidence: 99%

Tailoring of an anti-diabetic drug empagliflozin onto zinc oxide nanoparticles: characterization and in vitro evaluation of anti-hyperglycemic potential

Shoaib,

Shahid,

Mansoor

et al. 2024

Sci Rep

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Diabetes is a serious health issue that can be a great risk factor related to numerous physical problems. A class of drugs “Gliflozin” especially Sodium Glucose Co. Transporter 2 was inhibited by a novel drug, which is known as “empagliflozin”. While ZnO nanoparticles (NPs) had considerable promise for combating diabetes, it was employed in the treatment and management of type-2 diabetes mellitus. The new drug empagliflozin was initially incorporated into Zinc Oxide NPs in this study using the surface physio-sorption technique, and the degree of drug adsorption was assessed using the HPLC method. The tailored product was characterized by using the FTIR, EDX, Ultraviolet–Visible, XRD and SEM techniques. With an average particle size of 17 nm, SEM revealed mono-dispersion of NPs and sphere-like form. The Freundlich isotherm model best fits and explains the data for the physio-sorption investigation, which examined adsorption capabilities using adsorption isotherms. The enzymes α-amylase and α-glucosidase, which are involved in the human metabolism of carbohydrates, were used in the in-vitro anti-diabetic assays. It was discovered that the composite showed the highest levels of 81.72 and 92.77% inhibition of -α-amylase and -glucosidase at an absolute concentration of 1000 μg per ml with IC50 values of 30.6 μg per ml and 72 μg per ml.

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Citicoline loaded nanoemulsion enriched with D-alpha-Tocopherol acetate and protein: Formulation and in-silico study

Cited by 9 publications

References 60 publications

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

Transethosomes: Cutting edge approach for drug permeation enhancement in transdermal drug delivery system

Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate

Tailoring of an anti-diabetic drug empagliflozin onto zinc oxide nanoparticles: characterization and in vitro evaluation of anti-hyperglycemic potential

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