The unprecedented coronavirus pandemic (COVID-19) is fluctuating worldwide. Since the COVID-19 epidemic has a negative impact on all countries and has become a significant threat, it is necessary to determine the most effective strategy for governments by considering a variety of criteria; however, few studies in the literature can assist governments in this topic. Selective governmental intervention during the COVID-19 outbreak is considered a Multi-Criteria Decision-Making (MCDM) problem under a vague and uncertain environment when governments and medical communities adjust their priorities in response to rising issues and the efficacy of interventions applied in various nations. In this study, a novel hybrid Spherical Fuzzy Analytic Hierarchy Process (SF-AHP) and Fuzzy Weighted Aggregated Sum Product Assessment (WASPAS-F) model is proposed to help stakeholders such as governors and policymakers to prioritize governmental interventions for dealing with the COVID-19 outbreak. The SF-AHP is implemented to measure the significance of the criteria, while the WASPAS-F approach is deployed to rank intervention alternatives. An empirical case study is conducted in Vietnam. From the SF-AHP findings, the criteria of “effectiveness in preventing the spread of COVID-19”, “ease of implementation”, and “high acceptability to citizens” were recognized as the most important criteria. As for the ranking of strategies, “vaccinations”, “enhanced control of the country’s health resources”, “common health testing”, “formation of an emergency response team”, and “quarantining patients and those suspected of infection” are the top five strategies. Aside from that, the robustness of the approach was tested by performing a comparative analysis. The results illustrate that the applied methods reach the general best strategy rankings. The applied methodology and its analysis will provide insight to authorities for fighting against the severe pandemic in the long run. It may aid in solving many complicated challenges in government strategy selection and assessment. It is also a flexible design model for considering the evaluation criteria. Finally, this research provides valuable guidance for policymakers in other nations.