Citracridone-I: A New Antispasmodic from Root Barks ofCitrus depressa

Abstract

Citracridone-I (Citra-I), a new acridone alkaloid from the root barks of Citru.s depressa, was examined to evaluate toxicity in mice as well as blood pressure and small intestinal propulsion of rats in vivo. The antispasmodic effects of Citra-I were also investigated in the isolated ileum and vas deferens of guinea pig as well as uterine muscle of rat.

Volatile Organic Components of Fresh Leaves as Indicators of Indigenous and Cultivated Citrus Species in Taiwan

“…C. depressa has traditionally been used in Taiwan as a medicine to release gastrointestinal upsets, 7,8) and a special sauce has been made from C. tachibana. Studies on the compounds concerned with the health effect of C. depressa became popular due to the long lives of Okinawa residents who used it in daily food.…”

Antispasmodic activity on rat smooth muscle of polyphenol compounds caffeic and protocathechic acids

“…In research carried out at our laboratory we have observed that certain plant extracts that are rich in compounds of this type have antispasmodic effects (results unpublished). Other authors have proposed similar actions for plants species rich in phenols, flavonoids or other phenolic compounds (Calixto et al, 1986a;Calixto et al, 1986b;Van Puyvelde et al, 1987;Yang et al, 1987).…”

Phytochemical Diversity in the Order Rutales

“…To date they have been isolated only fron the Rutaceae. Acronycine (13), originally isolated from Baurella simplicijolia (= Acronychia baueri), is the best known of the acridones because of its wide spectrum cytotoxicity. primarily by Wu and his co-workers, has shown that the roots of Citrus species are particularly rich sources of acridones, including citropone-B (14)11 in which ring expansion has occurred.…”

“…8 Simple furoquinolines are reported to be mutagenic,12 and some acridones exhibit antispasmolytic activity. 13 The phototoxicity and resulting mutagenicity of furoquinolines is less pronounced than that of the corresponding furocoumarins.…”