Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers

Wibroe, Peter P.; Azmi, Intan Diana Mat; Nilsson, Christa; Yaghmur, Anan; Moghimi, S. Moein

doi:10.1016/j.nano.2015.08.003

Cited by 69 publications

(72 citation statements)

References 21 publications

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“…Depending on the lipid composition, the stabilizer type, and its concentration, non-lamellar liquid crystalline nanodispersions display a typically heterogeneous environment of coexisting morphologies [24,25,32,[52][53][54][55][56]. For instance, Pluronic F127-stabilized cubosomes and hexosomes typically coexist with vesicles [22,54,57,58].…”

Section: Resultsmentioning

confidence: 99%

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

2019

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Owing to their unique structural features, non-lamellar liquid crystalline nanoparticles comprising cubosomes and hexosomes are attracting increasing attention as versatile investigative drug carriers. Background: Depending on their physiochemical characteristics, drug molecules on entrapment can modulate and reorganize structural features of cubosomes and hexosomes. Therefore, it is important to assess the effect of guest molecules on broader biophysical characteristics of non-lamellar liquid crystalline nanoparticles, since drug-induced architectural, morphological, and size modifications can affect the biological performance of cubosomes and hexosomes. Methods: We report on alterations in morphological, structural, and size characteristics of nanodispersions composed from binary mixtures of glycerol monooleate and vitamin E on thymoquinone (a molecule with wide therapeutic potentials) loading. Results: Thymoquinone loading was associated with a slight increase in the mean hydrodynamic nanoparticle size and led to structural transitions from an internal biphasic feature of coexisting inverse cubic Fd3m and hexagonal (H2) phases to an internal inverse cubic Fd3m phase (micellar cubosomes) or an internal inverse micellar (L2) phase (emulsified microemulsions, EMEs). We further report on the presence of “flower-like” vesicular populations in both native and drug-loaded nanodispersions. Conclusions: These nanodispersions have the potential to accommodate thymoquinone and may be considered as promising platforms for the development of thymoquinone nanomedicines.

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Section: Resultsmentioning

confidence: 99%

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

2019

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“…Recent studies have shown successful developing of LC formulations that can be applicable for i.v. administration [32,33]. A previous study has demonstrated that PHT dispersions could trigger complement activation, and the process may limit their use for i.v.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of liquid–crystal oral formulations to enhance the bioavailability and skin tissue targeting of p -amino benzoic acid as a model compound

Kadhum

Oshizaka

Hijikuro³

et al. 2016

European Journal of Pharmaceutical Sciences

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Topical formulations are not always suitable to deliver active ingredients to large areas of skin. Thus, in this study, we aimed to develop an oral formulation for skin tissue targeting with a high bioavailability using liquid crystal (LC) dispersions comprising cubosomes of a mal-absorptive model compound, p-amino benzoic acid (PABA), which is an active element in cosmeceuticals, dietary supplements and skin disorder medicines. The bioavailability and skin concentration of PABA were investigated after oral administration in rats. The effect of the remaining amount of the LC formulation in the stomach on the pharmacokinetic profiles of orally administered PABA was evaluated. The skin permeation and concentration of PABA were also investigated using an in vitro permeation experiment. As a result, the bioavailability of PABA was significantly improved by administration of PABA-LC formulations compared with PABA solution alone, although the effect was greatly influenced by the type of LC-forming lipids. The in vitro skin permeation study showed that the PABA concentration in the skin when applied from the dermis side was higher than when applied from the epidermis side. These findings suggested that oral administration advantageously supports skin targeting, and oral LC formulations could be a promising material in cosmeceutical, dietary and clinical fields.

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“…A majority of their bio-interaction studies have placed emphasis on cytotoxicity, cellular uptake and intracellular distribution [11,26]. Only a few reports focusing on protein corona effects revealed that biological fluids (e.g., blood serum and artificial cell culture media) could alter the lattice parameters of the LLC systems [27,28], and possibly trigger a slow transition from one phase to the other [29]. Yet, it remains unclear how the presence of human immune cells encountered by these particles in circulation influence their structural qualities.…”

Section: Introductionmentioning

confidence: 99%

Monocytic Cell-Induced Phase Transformation of Circulating Lipid-Based Liquid Crystalline Nanosystems

et al. 2020

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Both lamellar and non-lamellar configurations are naturally present in bio-membranes, and the synthetic lipid-based liquid crystalline nano-assemblies, mimicking these unique structures, (including liposomes, cubosomes and hexosomes) are applicable in the controlled delivery of bioactives. However, it remains uncertain whether these nanosystems retain their original phase identity upon contact with blood circulating cells. This study highlights a novel biological cell flow-through approach at the synchrotron-based small angle X-ray scattering facility (bio-SAXS) to unravel their real-time phase evolution when incubated with human monocytic cells (THP-1) in suspension. Phytantriol-based cubosomes were identified to undergo monocytic cell-induced phase transformation from cubic to hexagonal phase periodicity. On the contrary, hexosomes exhibited time-dependent growth of a swollen hexagonal phase (i.e., larger lattice parameters) without displaying alternative phase characteristics. Similarly, liposomes remained undetectable for any newly evolved phase identity. Consequently, this novel in situ bio-SAXS study concept is valuable in delivering new important insights into the bio-fates of various lipid-based nanosystems under simulated human systemic conditions.

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Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers

Cited by 69 publications

References 21 publications

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

Non-Lamellar Liquid Crystalline Nanocarriers for Thymoquinone Encapsulation

Usefulness of liquid–crystal oral formulations to enhance the bioavailability and skin tissue targeting of p -amino benzoic acid as a model compound

Monocytic Cell-Induced Phase Transformation of Circulating Lipid-Based Liquid Crystalline Nanosystems

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