Citric acid crosslinking of mucilage from Cydonia oblonga engenders a superabsorbent, pH-sensitive and biocompatible polysaccharide offering on-off swelling and zero-order drug release

Hussain, Muhammad Ajaz; Kiran, L J; Haseeb, Muhammad Tahir; Hussain, Irshad; Hussain, Syed Zajif

doi:10.1007/s10965-020-2025-9

Cited by 18 publications

(8 citation statements)

References 30 publications

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“…They rapidly absorbed and released the swelling medium upon the pH alteration from acidic to primary conditions and vice versa ( Table S2 ). Even after many swelling–de-swelling cycles, the SPHHs-AT remained intact, ensuring its fundamental integrity despite changes in the pH of the external environment [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.

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Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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“…Interestingly, Hussain et al isolated polysaccharide-based stimuli-responsive hydrogel from arabinoxylan, basil seed, linseed, , Salvia spinosa seeds, and glucuronoxylan ,, for distinctive drug delivery. Primarily, these hydrogels do not utilize any chemical cross-linking agents for fabrication.…”

Section: Hydrogel Cross-linking Methodsmentioning

confidence: 99%

“…Primarily, these hydrogels do not utilize any chemical cross-linking agents for fabrication. However, citric acid was added as a cross-linking agent for synthesizing hydrogel from glucuronoxylan isolated from Mimosa pudica (MP) seeds and Cydonia oblonga seeds . In addition, the cross-linking methods of all the polysaccharide-based stimuli-responsive hydrogel reports in the past decade are listed in Table S1.…”

Section: Hydrogel Cross-linking Methodsmentioning

confidence: 99%

“…130 Additionally, Li et al reported phenylboronic modified chitosan and oxidized dextran hydrogel that were able to undergo covalent cross-linking through imine bond and phenylboronate ester for pH and glucose-responsive drug delivery. 131 Interestingly, Hussain et al isolated polysaccharide-based stimuli-responsive hydrogel from arabinoxylan, 20 basil seed, 21 linseed, 132,133 Salvia spinosa seeds, 134 and glucuronoxylan 33,135,136 for distinctive drug delivery. Primarily, these hydrogels do not utilize any chemical cross-linking agents for fabrication.…”

Section: Click Chemistrymentioning

confidence: 99%

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Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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Hydrogels are a soft material that undergoes cross-linking between polymers to form a hydrophilic three-dimensional network. In fact, similarity to body tissue, soft consistency, biocompatibility, and elasticity, impart a protagonic role of hydrogel to be applied as a biomaterial. In response to external cues, stimuli-responsive hydrogels are particularly impactful, enabling remarkable levels of control over material properties. They can endure changes in swelling behavior, permeability, network structure, and mechanical strength. Nevertheless, such changes induce single-cycle or reversible transitions, so hydrogels can regain their initial state once the trigger is removed. Recently, polysaccharide-based hydrogels with stimuli-responsive properties resulted in developing biomimetic structures for a widespread biotechnological application owing to their excellent biodegradability, biocompatibility, nonimmunogenicity, functional properties, ease of gelation, and derivatization. This review will initially highlight recent advances in cross-linking methods and chemistry for preparing stimuli-responsive hydrogels. Subsequently, state-of-the-art techniques to understand the structural, chemical, and rheological behavior of polysaccharide-based stimuli-responsive hydrogel will be discussed. Additionally, the responsiveness of polysaccharide hydrogel toward diverse stimuli such as redox, temperature, light, pH, magnetism, electricity, etc., with a broad spectrum of applications will be described in detail. This review also attempts to address the lacunae of existing stimuli-responsive hydrogel and their future perspectives.

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“…The pH-responsive dynamic and equilibrium swelling properties of PSH were evaluated using the tea-bag method, i.e., a 100 mesh screen. 32,33 Accurately weighed sample of PSH (0.1 g) was placed in each of the four tea bags and soaked in DW and buffer solutions of pH 1.2, 6.8 and 7.4. PSH-lled tea bags were placed in an incubator previously adjusted at room temperature.…”

Section: Isolation and Characterization Of Psyllium Hydrogelmentioning

confidence: 99%

A pH-sensitive, stimuli-responsive, superabsorbent, smart hydrogel from psyllium (Plantago ovata) for intelligent drug delivery

et al. 2021

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Citric acid crosslinking of mucilage from Cydonia oblonga engenders a superabsorbent, pH-sensitive and biocompatible polysaccharide offering on-off swelling and zero-order drug release

Cited by 18 publications

References 30 publications

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

A pH-sensitive, stimuli-responsive, superabsorbent, smart hydrogel from psyllium (Plantago ovata) for intelligent drug delivery

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