Citric Acid in Human Prostatic Secretion and Metastasizing Cancer of Prostate Gland

Marberger, H; Marberger, E; Mann, T.; Lutwak‐Mann, Cecilia

doi:10.1136/bmj.1.5281.835

Cited by 53 publications

(31 citation statements)

References 4 publications

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“…Citrate is thus an important in vivo marker of a malignant process. [8][9][10][11] Citrate concentrations in brain tissue (approximately 0.4 mmol/kg 12,13 ) and CSF (approximately 0.2 mmol/L 14 ) are very low, and, to the best of our knowledge, citrate has not been identified with in vivo MR spectroscopy in human brain tissue. …”

Section: Discussionmentioning

confidence: 99%

Citrate in Pediatric CNS Tumors?

Seymour

Panigrahy²,

Finlay³

et al. 2008

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Citrate in Pediatric CNS Tumors?

Seymour

Panigrahy²,

Finlay³

et al. 2008

AJNR Am J Neuroradiol

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“…The loss of citrate in the TRAMP metastatic lesions is also consistent with the decreased concentration of zinc in human prostate lymph node metastasis as Marberger et al had reported. 7 Zinc and ZIP1 in TRAMP animals. These studies were conducted by the UMd group on tissue samples from the UCSF studies described in the preceding section.…”

Section: Resultsmentioning

confidence: 99%

Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model

Costello

Franklin

Zou

et al. 2011

Cancer Biology & Therapy

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Prostate cancer is the second leading cause of cancer deaths among men. The availability of animal models that represent the events and factors that exist in the natural history and biology of human prostate cancer is essential in dealing with prostate cancer. In recent decades and presently, emphasis has been directed at the development and employment of prostate cancer induced in transgenic mice. However, the important consistent hallmark characteristic and event of decrease in zinc and citrate and downregulation of ZIP1 zinc transporter in prostate malignancy has not been studied or identified in any animal model. We investigated the status of these parameters in TRAMP tumors as compared with human prostate cancer. The results show that citrate levels are markedly decreased in the developing and advancing stages of malignancy in TRAMP. Zinc levels are also decreased and ZIP1 transporter is lost in TRAMP tumors. In vitro studies show that zinc treatment of TRAMP C2 cells exhibits cytotoxic effects. Collectively, these results mimic the ZIP1, zinc, and citrate status and relationship that exist in human prostate cancer. This is the first report that establishes the existence of the human prostate zinc/citrate hallmark characteristic and relationship in an animal model. It now appears that the TRAMP model will be suitable for studies relating to the implications and role of zinc-and citraterelated metabolism in the development and progression of human prostate cancer.

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“…In contrast, the citrate levels of malignant prostate tissue were significantly lower than the benign prostate levels. Marberger et al [10] reported that metastatic tissue derived from PCa contained very low citrate levels. These observations were corroborated and expanded by Cooper and Farid [1,2].…”

Section: The Citrate Relationship In Pcamentioning

confidence: 98%