2009
DOI: 10.1002/pbc.22210
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Citrulline as a marker for chemotherapy induced mucosal barrier injury in pediatric patients

Abstract: MBI was reflected by parameters indicating inflammation (IL-8) and cell loss (plasma citrulline, ratio fecal human DNA/total DNA). We conclude that plasma citrulline might be a good parameter for MBI. Further studies are needed to show whether plasma citrulline can be used as a marker for MBI in future research.

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Cited by 95 publications
(81 citation statements)
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“…Plasma citrulline levels were measured in 30 l plasma at room temperature by using automated ion exchange column chromatography as described previously (37,38).…”
Section: Methodsmentioning
confidence: 99%
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“…Plasma citrulline levels were measured in 30 l plasma at room temperature by using automated ion exchange column chromatography as described previously (37,38).…”
Section: Methodsmentioning
confidence: 99%
“…We measured plasma citrulline levels to estimate the level of functional enterocyte mass during mucositis (6) and to see whether plasma citrulline can serve as a noninvasive marker for mucositis, as has been suggested previously (3,21,22,38). Citrulline levels were 3.6-fold decreased in MTX-treated rats compared with controls (P Ͻ 0.01, Fig.…”
Section: The Mucositis Rat Model During the Present Experimentsmentioning
confidence: 99%
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“…Daha da ötesi, OM şiddetine göre KT/RT dozlarının azaltılmasına, tedavinin yavaşlatılmasına ve hatta tamamen kesilmesine neden olabilir. [10][11][12][13][14][15] A Ağ ğr rı ı v ve e a ağ ğr rı ıy ya a b ba ağ ğl lı ı g ge el li iş şe en n s so or ru un nl la ar r: : Mukozitli hastaların çoğunda ağrı en yaygın sorundur. Mukozitteki ağrı; yutkunma esnasında, ağzın açılması, beslenme ve ağız bakımı esnasında gelişir.…”
Section: Kli̇ni̇k Sonuçlariunclassified
“…OM'ye bağlı ağrı ve bulantı, kusma, ishal, iştahsızlık, enterit, malabsorpsiyon ve karaciğer fonksiyon bozukluğu gibi KT'nin diğer yan etkileri eşlik ediyorsa hastanın beslenme durumu iyice kötüleşir. 4,7,[9][10][11][12]17 Hafif OM olan hastalar (evre 1, 2) ağızlarında rahatsızlık hissedebilirler ve bu onların çoğu besinleri almalarını engelleyebilir. Sıvı ve yumuşak besinlerle beslenmesini sürdürürse bir-iki gün içe-risinde beslenme sorunu gelişmeden OM iyileşir.…”
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