2020
DOI: 10.1101/2020.06.15.153346
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Citrulline supplementation improves spatial memory in a murine model for Alzheimer’s disease

Abstract: INTRODUCTION: Alzheimer's disease (AD) correlates with the dysfunction of metabolic pathways that translates into neurological symptoms. An arginine deficiency, a precursor of nitric oxide (NO), has been reported for AD patients. We aimed to evaluate the effect of citrulline oral supplementation on cognitive decline in an AD murine model. METHODS: Three-month citrulline or water supplementation was blindly given to male and female wild type and 3xTg-AD mice trained and tested in the Morris Water Maze (MWM). Ce… Show more

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“…Our approach has been recently tested with another non-competitive arginase inhibitor, citrulline, in AD mice [ 172 ]. The treated animals demonstrated increased arginine CSF levels and performed significantly better in a maze.…”
Section: Polyamine Pathway In Alzheimer’s Diseasementioning
confidence: 99%
“…Our approach has been recently tested with another non-competitive arginase inhibitor, citrulline, in AD mice [ 172 ]. The treated animals demonstrated increased arginine CSF levels and performed significantly better in a maze.…”
Section: Polyamine Pathway In Alzheimer’s Diseasementioning
confidence: 99%