Citrus Flavonoids and Effects in Dementia and Age-Related Cognitive Decline

Hwang, Sam-Long; Shih, Ping‐Hsiao; Yen, Gow‐Chin

doi:10.1016/b978-0-12-407824-6.00080-x

Cited by 7 publications

(5 citation statements)

References 50 publications

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“…In this study, phytochemical analysis of ethanol fruit extract of P. dactylifera revealed the presence of secondary metabolites such as, flavonoids, saponins, tannins and alkaloids which have been reported to have neuroprotective activities (Chan et al, 2012;Wan Ismail and MohdRadzi, 2013;Hwang et al, 2015). This finding is in agreement with the reported phytochemical constituents in fruit extract of P. dactylifera L. (Faqir et al, 2012;Abiola et al, 2017).…”

Section: Discussionsupporting

confidence: 89%

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

Lazarus¹,

Adebisi²,

Tanko³

et al. 2018

Afr. J. Cell. Path

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This study histologically and histochemically assess the effect of ethanol fruit extract of Phoenix dactylifera L. (EFPD) on the cerebral cortex of lead acetate exposed Wistar rats. Twenty rats were grouped into five groups (A to E, n=4). Group A (control) was administered distilled water (2 ml/kg), while groups B to E were treatment groups. Cerebral damage was induced in rats by the administration of lead acetate (120 mg/kg). Groups B, C, D and E were administered lead acetate (120 mg/kg) for a period of 3 weeks, after which groups C and D were administered EFPD (500 and 1000 mg/kg, respectively) and group E was administered dimercaptosuccinic acid (10 mg/kg) for 2 weeks. All administrations were via oral route, once daily. Microscopic examination of cerebral sections of lead acetate-treated rats revealed histo-architectural alteration; cortical degenerative changes, such as, necrosis, satellitosis, vacuolation and neuronal cytoplasmic shrinkage. However, administration of EFPD remarkably ameliorated lead acetate-induced cortical cerebral degenerative changes in the rats, in a dose dependently manner, as compared to the reference drug dimercaptosuccinic acid. Results suggest that EFPD is a potential therapeutic agent against lead acetate-induced cortical cerebral alterations in Wistar rats.

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Section: Discussionsupporting

confidence: 89%

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

Lazarus¹,

Adebisi²,

Tanko³

et al. 2018

Afr. J. Cell. Path

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“…Flavonoids are one of the most well-known natural products, often regarded as major scaffolds in medicinal chemistry [ 27 ]. Flavonoids showed antioxidant [ 28 ], anti-inflammatory [ 29 ], and sedative [ 30 ] effects in various studies. Moreover, flavonoid scaffolds present the outstanding potential of being chemoprotective agents toward cancer [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Flavonoids as Putative Epi-Modulators: Insight into Their Binding Mode with BRD4 Bromodomains Using Molecular Docking and Dynamics

Prieto‐Martínez

Medina-Franco

2018

Biomolecules

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Flavonoids are widely recognized as natural polydrugs, given their anti-inflammatory, antioxidant, sedative, and antineoplastic activities. Recently, different studies showed that flavonoids have the potential to inhibit bromodomain and extraterminal (BET) bromodomains. Previous reports suggested that flavonoids bind between the Z and A loops of the bromodomain (ZA channel) due to their orientation and interactions with P86, V87, L92, L94, and N140. Herein, a comprehensive characterization of the binding modes of fisetin and the biflavonoid, amentoflavone, is discussed. To this end, both compounds were docked with BET bromodomain 4 (BRD4) using four docking programs. The results were post-processed with protein–ligand interaction fingerprints. To gain further insight into the binding mode of the two natural products, the docking results were further analyzed with molecular dynamics simulations. The results showed that amentoflavone makes numerous contacts in the ZA channel, as previously described for flavonoids and kinase inhibitors. It was also found that amentoflavone can potentially make contacts with non-canonical residues for BET inhibition. Most of these contacts were not observed with fisetin. Based on these results, amentoflavone was experimentally tested for BRD4 inhibition, showing activity in the micromolar range. This work may serve as the basis for scaffold optimization and the further characterization of flavonoids as BET inhibitors.

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“…In our paper, the content of linoleic acid in E. konishii was signi cantly upregulated under cold treatment and involved in the linoleic acid metabolic pathway, indicating that the accumulation of linoleic acid is important for maintaining a certain resistance to cold stress in E. konishii. Neohesperidin, hesperidin, and naringin are citrus avonoids with antioxidant and anti-in ammatory pharmacological activities that are also used to ameliorate memory impairment and Aβ pathology and control the progression of bone diseases (Hwang et al, 2015;Ortiz et al, 2022). Notably, hesperidin also maintains osmotic pressure, enhances capillary toughness, lowers cholesterol, etc.…”

Section: Amino Acid Metabolism Of the Two Species Differs Coldmentioning

confidence: 99%

Comparative metabolomics analysis reveals the response of Euscaphis konishii and Euscaphis japonica to cold

Jiang,

Lu,

et al. 2023

Preprint

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Euscaphis konishii and Euscaphis japonica are shrubs or small trees belonging to the Staphyleaceae family, and are excellent ornamental fruit plants with high ornamental and medicinal value. There are few studies on the cold tolerance of E. konishii and E. japonica, and their metabolic response to cold is not clear. Here, the non-targeted metabolomics (GC‒MS) technique was used to elucidate the response of E. konishii and E. japonica to cold at the metabolic level. Under cold treatment, E. konishii exhibited 10 upregulated and 1 downregulated differentially expressed metabolites (DEMs), whereas 10 upregulated 7 downregulated DEMs were identified in E. japonica. The contents of key metabolites, such as sugars including raffinose and glucose-6-phosphate, amino acids including lysine and methionine 2, unsaturated fatty acids including linoleic acid, and flavonoid compounds including neohesperidin were increased in E. konishii in response to cold. The contents of key metabolites such as sugars including raffinose, trehalose, and fructose-6-phosphate, amino acids including aspartic acid 1 and aspartic acid 2, and organic acids including pyruvate and taurine were increased, and sugars of sedoheptulose, organic acids of α-ketoglutaric acid, flavonoid compounds of hesperidin were decreased in E. japonica in response to cold. DEMs in E. konishii were significantly enriched in “linoleic acid metabolism”, while the DEMs in E. japonica were significantly enriched in “monobactam biosynthesis”, “cysteine and methionine metabolism”, “taurine and hypotaurine metabolism”, “sulfur metabolism” and “ABC transporters”. This research expounds the metabolic differences of E. konishii and E. japonica in response to cold, and provides a foundation for improving their resistance to cold stress.

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Citrus Flavonoids and Effects in Dementia and Age-Related Cognitive Decline

Cited by 7 publications

References 50 publications

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

Histological and histochemical assessements on the effect of ethanol fruit extract of Phoenix dactylifera L. (Date Palm) on cerebral cortex of lead acetate treated wistar rats

Flavonoids as Putative Epi-Modulators: Insight into Their Binding Mode with BRD4 Bromodomains Using Molecular Docking and Dynamics

Comparative metabolomics analysis reveals the response of Euscaphis konishii and Euscaphis japonica to cold

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