CKM Gene rs8111989 Polymorphism and Power Athlete Status

Abstract

Multiple genetic variants are known to influence athletic performance. These include polymorphisms of the muscle-specific creatine kinase (CKM) gene, which have been associated with endurance and/or power phenotypes. However, independent replication is required to support those findings. The aim of the present study was to determine whether the CKM (rs8111989, c.*800A>G) polymorphism is associated with power athlete status in professional Russian and Lithuanian competitors. Genomic DNA was collected from 693 national and international standard athletes from Russia (n = 458) and Lithuania (n = 235), and 500 healthy non-athlete subjects from Russia (n = 291) and Lithuania (n = 209). Genotyping for the CKM rs8111989 (A/G) polymorphism was performed using PCR or micro-array analysis. Genotype and allele frequencies were compared between all athletes and non-athletes, and between non-athletes and athletes, segregated according to population and sporting discipline (from anaerobic-type events). No statistically significant differences in genotype or allele frequencies were observed between non-athletes and power athletes (strength-, sprint- and speed/strength-oriented) athletes. The present study reports the non-association of the CKM rs8111989 with elite status in athletes from sports in which anaerobic energy pathways determine success.

Association of the CKM rs8111989 Polymorphism with Injury Epidemiology in Football Players

“…This is because creatine kinase catalyses the conversion of phosphocreatine and adenosine diphosphate into creatine and ATP, respectively. Therefore, the efficiency of ATP generation during muscle contraction is affected by the activity of creatine kinase, particularly during short-duration, maximal-intensity exercise activities where both ATP and phosphocreatine are the main sources of energy [3]. In fact, the activity of creatine kinase in catalysing the resynthesis of ATP is two-fold in fast twitch muscle fibres compared to slow twitch muscle fibres [4], which indicates that the activity of this protein is one of the characteristics of fast muscle fibres.…”

Quantitative Proteomic Analysis of Zearalenone Exposure on Uterine Development in Weaned Gilts

“…The confirmed up-regulated expression of CKM, MME, and MPO and down-regulated expression of ALDH1A2, CHGB, and SUGP1 by western blot indicated that our proteomics data were dependable. CKM was a catalytic activity protein that can reversibly catalyze various phosphogens between ATP and ADP, thereby playing an important role in maintaining the cellular energy homeostasis [ 51 ]. Moreover, Xiong et al [ 52 ] reported that CKM was highly expressed in skeletal muscle and myocardium, and its gene expression was increased after muscle cell differentiation.…”

Genetic Polymorphisms and Their Impact on Body Composition and Performance of Brazilians in a 105 Km Mountain Ultramarathon

“…Particularly for mountain ultramarathon athletes, these polymorphisms might manifest unique genotypic distributions, playing a pivotal role in adaptations and athletic performance. This is exemplified by studies covering power-oriented athletes [ 22 ], climbers [ 23 ], marathon runners [ 24 ], and ultramarathon runners [ 25 ].…”