Claimed effects, outcome variables and methods of measurement for health claims on foods proposed under Regulation (EC) 1924/2006 in the area of oral health

Martini, Daniela; Galli, Carlo; Guareschi, Cristina; Angelino, Donato; Bedogni, Giorgio; Biasini, Beatrice; Zavaroni, Ivana; Pruneti, Carlo; Ventura, Marco; Galli, Daniela; Mirandola, Prisco; Vitale, Marco; Dei, Alessandra; Bonadonna, Riccardo C.; Passeri, Giovanni; Rio, Daniele Del

doi:10.1016/j.nfs.2017.12.001

Cited by 7 publications

(7 citation statements)

References 89 publications

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“…Although, the use and scope of the term probiotics has been defined, to arrive at a proper definition of the term, precise reporting in research investigations would serve as a feedback. Methodological shortcomings in screening for probiotics are highlighted in several reports: poor documentation of clinical trials (for example, concerning the mode of administration and preclinical documentation), of probiotics used in different investigations, duration of intervention, clinical parameters used, the subjects, and studies lacking randomization and being insufficiently powered to assess adverse events . The consequences of such lapses are that many health claims made for probiotics are rejected by regulatory authorities .…”

Section: Towards a Firm Foundation – A Critical Look At The Common Grmentioning

confidence: 99%

“…The consequences of such lapses are that many health claims made for probiotics are rejected by regulatory authorities . Streamlining information from different studies will help maintain the credibility of claims …”

Section: Towards a Firm Foundation – A Critical Look At The Common Grmentioning

confidence: 99%

“…17,41 Streamlining information from different studies will help maintain the credibility of claims. 17,42 Issues relating to microbial systematics Resolving taxonomic issues will help to consolidate research findings. When new organisms are isolated and screened for specific antagonistic or probiotic potential, the investigators often face many pitfalls with regard to characterization.…”

Section: Towards a Firm Foundation -A Critical Look At The Common Gromentioning

confidence: 99%

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A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

Karunaratne

2018

J Sci Food Agric

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Investigations into probiotics have focused on their health benefits thus far, with some of the findings finally reaching the food and pharmaceutical industries, which have used them for commercial purposes. In biocontrol research some microbes, mainly isolated from plants, have shown antagonism towards both enteric and plant pathogens, and some of them represent probiotic species. Fresh fruits and vegetables are regarded as health-promoting dietary constituents, and if probiotics could be used to control the pathogens on them then they could turn out to be even healthier. The fresh produce industry still depends on agrochemicals and the increase in the demand for high-priced organically grown produce indicates consumer concerns regarding the use of agrochemicals. If the potential of probiotic organisms to serve as biocontrol agents for fresh produce is exploited, all fresh produce can be made as safe as organically grown produce, and much more wholesome. This review appraises the feasibility of such a move by evaluating how research has progressed in both disciplines (probiotic and biocontrol) and suggests sharing results from research via information technology, efficient collaboration, and the use of novel molecular biological tools to achieve the objective of probiotic antagonists. © 2018 Society of Chemical Industry.

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Section: Towards a Firm Foundation – A Critical Look At The Common Grmentioning

confidence: 99%

Section: Towards a Firm Foundation – A Critical Look At The Common Grmentioning

confidence: 99%

Section: Towards a Firm Foundation -A Critical Look At The Common Gromentioning

confidence: 99%

See 1 more Smart Citation

A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

Karunaratne

2018

J Sci Food Agric

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“…Some bacteria present in the biofilm metabolize small carbohydrates to produce energy, and subsequently organic acids as byproducts. These organic acids can decrease the biofilm pH below the critical threshold (5.5 for the enamel and 6.2 for dentin), and cause demineralization of tooth structure [2]. Surface and subsurface carious lesions may develop gradually as the result of a dynamic process of demineralization and remineralization [3].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of cavity liners with/without atmospheric cold helium plasma jet for dentin remineralization

Kermanshah

Saeedi

Ahmadi

et al. 2020

Biomaterial Investigations in Dentistry

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Aim: This study aimed to assess the efficacy of cavity liners with/without the atmospheric cold plasma jet (ACPJ) for dentin remineralization. Material and methods: The occlusal third of 24 extracted third molars was cut. An occlusal cavity was prepared in the dentin of each tooth with 1 mm depth and 2 mm diameter and demineralized with 37% phosphoric acid for 1 min. The teeth were randomly divided into 8 groups (n ¼ 3). The first control group only underwent demineralization with phosphoric acid. The second control group underwent demineralization and helium plasma jet. Groups 3 to 5 were filled with calcium hydroxide (CH), RetroMTA (MTA) and Biodentine. Groups 6 to 8 were subjected to ACPJ, and all the groups were sealed with polycarboxylate. After 2 weeks of immersion in water, the teeth were longitudinally sectioned and their mineral content was analyzed using energy-dispersive X-ray spectroscopy (EDX). Results: The interaction effect of ACPJ and type of liner was not significant (p > 0.05). Application of ACPJ in combination with liner had a significant effect on calcium and phosphorous contents (p < .05). The calcium and phosphorous contents in the control groups were significantly lower than other groups (p < .05). The calcium and phosphorous contents in the CH group were higher than the control but significantly lower than the MTA and Biodentine groups. The values in the MTA and Biodentine groups were the same and higher than other groups. Conlusion: All three cavity liners significantly increased the calcium and phosphorous contents of dentin. This increase was significantly greater by the MTA and Biodentine and enhanced by the ACPJ.

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“…Based on this consideration, a project has been developed to collect, collate and critically analyse OVs and MMs that have been proposed for the substantiation of health claims, with the aim of improving the quality of applications submitted by applicants to EFSA. Previous papers related to different areas of interest have been already published [ 7 , 8 , 9 , 10 , 11 ]. This manuscript refers to the collection, collation and critical analysis of OVs and MMs related to vision.…”

Section: Introductionmentioning

confidence: 99%

Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006

et al. 2018

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Adequate visual function has a strong impact on the quality of life of people. Several foods and food components have been hypothesized to play a role in the maintenance of normal visual function and in the prevention of eye diseases. Some of these foods/food components have been the object of a request of authorization for use of health claims under Articles 13(5) or 14 of the Regulation (EC) 1924/2006. Most of these requests have received a negative opinion from the European Food Safety Authority (EFSA) due to the choice of inappropriate outcome variables (OVs) and/or methods of measurement (MMs) applied in the studies used to substantiate the claims. This manuscript refers to the collection, collation and critical analysis of OVs and MMs related to vision. Guidance document and requests for authorization of health claims were used to collect OVs and MMs related to vision. A literature review was performed to critically analyse OVs and MMs, with the aim of defining their appropriateness in the context of a specific claimed effect related to vision. The results highlight the importance of adequate choices of OVs and MMs for an effective substantiation of claims related to visual function.

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Claimed effects, outcome variables and methods of measurement for health claims on foods proposed under Regulation (EC) 1924/2006 in the area of oral health

Cited by 7 publications

References 89 publications

A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

A multifaceted approach to harness probiotics as antagonists on plant based foods, for enhanced benefits to be reaped at a global level

Efficacy of cavity liners with/without atmospheric cold helium plasma jet for dentin remineralization

Claimed Effects, Outcome Variables and Methods of Measurement for Health Claims on Foods Related to Vision Proposed Under Regulation (EC) 1924/2006

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